ID KR195_HUMAN Reviewed; 72 AA. AC Q3LI72; A4IF22; DT 21-FEB-2006, integrated into UniProtKB/Swiss-Prot. DT 08-NOV-2005, sequence version 1. DT 03-MAY-2023, entry version 111. DE RecName: Full=Keratin-associated protein 19-5; GN Name=KRTAP19-5; Synonyms=KAP19.5; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; OC Homo. OX NCBI_TaxID=9606; RN [1] RP NUCLEOTIDE SEQUENCE [MRNA]. RC TISSUE=Hair root; RA Obayashi I., Shibuya K., Minoshima S., Kudoh J., Shimizu N.; RT "Identification of complete keratin-associated protein (KAP) gene cluster RT spanning 800 kb region on human chromosome 21q22.11."; RL Submitted (NOV-2002) to the EMBL/GenBank/DDBJ databases. RN [2] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. RX PubMed=15489334; DOI=10.1101/gr.2596504; RG The MGC Project Team; RT "The status, quality, and expansion of the NIH full-length cDNA project: RT the Mammalian Gene Collection (MGC)."; RL Genome Res. 14:2121-2127(2004). CC -!- FUNCTION: In the hair cortex, hair keratin intermediate filaments are CC embedded in an interfilamentous matrix, consisting of hair keratin- CC associated proteins (KRTAP), which are essential for the formation of a CC rigid and resistant hair shaft through their extensive disulfide bond CC cross-linking with abundant cysteine residues of hair keratins. The CC matrix proteins include the high-sulfur and high-glycine-tyrosine CC keratins. CC -!- SUBUNIT: Interacts with hair keratins. {ECO:0000250}. CC -!- INTERACTION: CC Q3LI72; Q8IWG5: ANKHD1; NbExp=3; IntAct=EBI-1048945, EBI-355540; CC Q3LI72; P41238: APOBEC1; NbExp=3; IntAct=EBI-1048945, EBI-12819523; CC Q3LI72; Q03989: ARID5A; NbExp=3; IntAct=EBI-1048945, EBI-948603; CC Q3LI72; Q86V38: ATN1; NbExp=6; IntAct=EBI-1048945, EBI-11954292; CC Q3LI72; Q8N5M1: ATPAF2; NbExp=3; IntAct=EBI-1048945, EBI-1166928; CC Q3LI72; O14503: BHLHE40; NbExp=3; IntAct=EBI-1048945, EBI-711810; CC Q3LI72; Q9UQM7: CAMK2A; NbExp=3; IntAct=EBI-1048945, EBI-1383687; CC Q3LI72; Q13554: CAMK2B; NbExp=3; IntAct=EBI-1048945, EBI-1058722; CC Q3LI72; Q8NEC5: CATSPER1; NbExp=3; IntAct=EBI-1048945, EBI-744545; CC Q3LI72; Q96LX7-5: CCDC17; NbExp=3; IntAct=EBI-1048945, EBI-12165781; CC Q3LI72; Q8N6W0: CELF5; NbExp=3; IntAct=EBI-1048945, EBI-12139335; CC Q3LI72; Q9H2X0: CHRD; NbExp=3; IntAct=EBI-1048945, EBI-947551; CC Q3LI72; P27658: COL8A1; NbExp=3; IntAct=EBI-1048945, EBI-747133; CC Q3LI72; Q9BSW2: CRACR2A; NbExp=3; IntAct=EBI-1048945, EBI-739773; CC Q3LI72; Q02930-3: CREB5; NbExp=3; IntAct=EBI-1048945, EBI-10192698; CC Q3LI72; P02489: CRYAA; NbExp=3; IntAct=EBI-1048945, EBI-6875961; CC Q3LI72; A8MQ03: CYSRT1; NbExp=3; IntAct=EBI-1048945, EBI-3867333; CC Q3LI72; O75553: DAB1; NbExp=3; IntAct=EBI-1048945, EBI-7875264; CC Q3LI72; Q15038: DAZAP2; NbExp=11; IntAct=EBI-1048945, EBI-724310; CC Q3LI72; Q9NQL9: DMRT3; NbExp=3; IntAct=EBI-1048945, EBI-9679045; CC Q3LI72; Q96MA1: DMRTB1; NbExp=3; IntAct=EBI-1048945, EBI-954466; CC Q3LI72; P50570-2: DNM2; NbExp=3; IntAct=EBI-1048945, EBI-10968534; CC Q3LI72; O95967: EFEMP2; NbExp=3; IntAct=EBI-1048945, EBI-743414; CC Q3LI72; Q9H0I2: ENKD1; NbExp=3; IntAct=EBI-1048945, EBI-744099; CC Q3LI72; Q6NXG1: ESRP1; NbExp=3; IntAct=EBI-1048945, EBI-10213520; CC Q3LI72; Q03828: EVX2; NbExp=3; IntAct=EBI-1048945, EBI-17280301; CC Q3LI72; Q92567-2: FAM168A; NbExp=3; IntAct=EBI-1048945, EBI-11978259; CC Q3LI72; Q7L5A3: FAM214B; NbExp=3; IntAct=EBI-1048945, EBI-745689; CC Q3LI72; P22607: FGFR3; NbExp=3; IntAct=EBI-1048945, EBI-348399; CC Q3LI72; P01100: FOS; NbExp=3; IntAct=EBI-1048945, EBI-852851; CC Q3LI72; Q9BZE0: GLIS2; NbExp=5; IntAct=EBI-1048945, EBI-7251368; CC Q3LI72; Q8IVS8: GLYCTK; NbExp=3; IntAct=EBI-1048945, EBI-748515; CC Q3LI72; O95872: GPANK1; NbExp=3; IntAct=EBI-1048945, EBI-751540; CC Q3LI72; P62993: GRB2; NbExp=3; IntAct=EBI-1048945, EBI-401755; CC Q3LI72; Q7Z429: GRINA; NbExp=3; IntAct=EBI-1048945, EBI-2832909; CC Q3LI72; P06396: GSN; NbExp=3; IntAct=EBI-1048945, EBI-351506; CC Q3LI72; Q96NT3-2: GUCD1; NbExp=3; IntAct=EBI-1048945, EBI-11978177; CC Q3LI72; Q9GZV7: HAPLN2; NbExp=3; IntAct=EBI-1048945, EBI-11956675; CC Q3LI72; A0A024R5S0: hCG_2003792; NbExp=3; IntAct=EBI-1048945, EBI-10188461; CC Q3LI72; V9HW27: HEL-S-101; NbExp=3; IntAct=EBI-1048945, EBI-10178933; CC Q3LI72; O14964: HGS; NbExp=3; IntAct=EBI-1048945, EBI-740220; CC Q3LI72; P17482: HOXB9; NbExp=3; IntAct=EBI-1048945, EBI-745290; CC Q3LI72; Q0VD86: INCA1; NbExp=5; IntAct=EBI-1048945, EBI-6509505; CC Q3LI72; Q9BVG8-5: KIFC3; NbExp=3; IntAct=EBI-1048945, EBI-14069005; CC Q3LI72; Q92876: KLK6; NbExp=3; IntAct=EBI-1048945, EBI-2432309; CC Q3LI72; Q5T749: KPRP; NbExp=3; IntAct=EBI-1048945, EBI-10981970; CC Q3LI72; O76011: KRT34; NbExp=3; IntAct=EBI-1048945, EBI-1047093; CC Q3LI72; P60329: KRTAP12-4; NbExp=3; IntAct=EBI-1048945, EBI-10176396; CC Q3LI72; Q3LI76: KRTAP15-1; NbExp=3; IntAct=EBI-1048945, EBI-11992140; CC Q3LI72; Q3LI66: KRTAP6-2; NbExp=3; IntAct=EBI-1048945, EBI-11962084; CC Q3LI72; Q8IUC2: KRTAP8-1; NbExp=3; IntAct=EBI-1048945, EBI-10261141; CC Q3LI72; Q9Y5V3: MAGED1; NbExp=9; IntAct=EBI-1048945, EBI-716006; CC Q3LI72; Q8NDC0: MAPK1IP1L; NbExp=3; IntAct=EBI-1048945, EBI-741424; CC Q3LI72; Q8TDC0: MYOZ3; NbExp=3; IntAct=EBI-1048945, EBI-5662487; CC Q3LI72; Q86VE0: MYPOP; NbExp=3; IntAct=EBI-1048945, EBI-2858213; CC Q3LI72; O43482: OIP5; NbExp=3; IntAct=EBI-1048945, EBI-536879; CC Q3LI72; Q7RTU3: OLIG3; NbExp=3; IntAct=EBI-1048945, EBI-10225049; CC Q3LI72; Q8TDS5: OXER1; NbExp=3; IntAct=EBI-1048945, EBI-12813389; CC Q3LI72; Q7Z4N8: P4HA3; NbExp=3; IntAct=EBI-1048945, EBI-10181968; CC Q3LI72; Q9HBE1-4: PATZ1; NbExp=5; IntAct=EBI-1048945, EBI-11022007; CC Q3LI72; P78337: PITX1; NbExp=3; IntAct=EBI-1048945, EBI-748265; CC Q3LI72; Q99697-2: PITX2; NbExp=3; IntAct=EBI-1048945, EBI-12138495; CC Q3LI72; Q9NRQ2: PLSCR4; NbExp=3; IntAct=EBI-1048945, EBI-769257; CC Q3LI72; Q16633: POU2AF1; NbExp=3; IntAct=EBI-1048945, EBI-943588; CC Q3LI72; Q96I34: PPP1R16A; NbExp=3; IntAct=EBI-1048945, EBI-710402; CC Q3LI72; Q7Z5V6-2: PPP1R32; NbExp=3; IntAct=EBI-1048945, EBI-12000762; CC Q3LI72; Q9UGI9: PRKAG3; NbExp=3; IntAct=EBI-1048945, EBI-7428853; CC Q3LI72; Q8WWY3: PRPF31; NbExp=3; IntAct=EBI-1048945, EBI-1567797; CC Q3LI72; Q9NZ81: PRR13; NbExp=5; IntAct=EBI-1048945, EBI-740924; CC Q3LI72; P86480: PRR20D; NbExp=3; IntAct=EBI-1048945, EBI-12754095; CC Q3LI72; P25788: PSMA3; NbExp=3; IntAct=EBI-1048945, EBI-348380; CC Q3LI72; P49721: PSMB2; NbExp=3; IntAct=EBI-1048945, EBI-359335; CC Q3LI72; P28070: PSMB4; NbExp=3; IntAct=EBI-1048945, EBI-603350; CC Q3LI72; Q93062: RBPMS; NbExp=4; IntAct=EBI-1048945, EBI-740322; CC Q3LI72; Q93062-3: RBPMS; NbExp=6; IntAct=EBI-1048945, EBI-740343; CC Q3LI72; Q6ZRY4: RBPMS2; NbExp=3; IntAct=EBI-1048945, EBI-11987469; CC Q3LI72; Q9BQY4: RHOXF2; NbExp=6; IntAct=EBI-1048945, EBI-372094; CC Q3LI72; Q9H0F5: RNF38; NbExp=3; IntAct=EBI-1048945, EBI-2341200; CC Q3LI72; Q7L0R7: RNF44; NbExp=3; IntAct=EBI-1048945, EBI-2845060; CC Q3LI72; Q14D33: RTP5; NbExp=3; IntAct=EBI-1048945, EBI-10217913; CC Q3LI72; Q9BVN2: RUSC1; NbExp=3; IntAct=EBI-1048945, EBI-6257312; CC Q3LI72; Q13214-2: SEMA3B; NbExp=3; IntAct=EBI-1048945, EBI-11017428; CC Q3LI72; Q16637: SMN2; NbExp=3; IntAct=EBI-1048945, EBI-395421; CC Q3LI72; Q8NCR6: SMRP1; NbExp=3; IntAct=EBI-1048945, EBI-10269322; CC Q3LI72; P09234: SNRPC; NbExp=3; IntAct=EBI-1048945, EBI-766589; CC Q3LI72; Q5JUK2: SOHLH1; NbExp=3; IntAct=EBI-1048945, EBI-12288855; CC Q3LI72; Q9NQB0-10: TCF7L2; NbExp=3; IntAct=EBI-1048945, EBI-11746252; CC Q3LI72; Q9BXF9: TEKT3; NbExp=3; IntAct=EBI-1048945, EBI-8644516; CC Q3LI72; Q96LM6: TEX37; NbExp=3; IntAct=EBI-1048945, EBI-743976; CC Q3LI72; Q08117-2: TLE5; NbExp=3; IntAct=EBI-1048945, EBI-11741437; CC Q3LI72; Q15025: TNIP1; NbExp=3; IntAct=EBI-1048945, EBI-357849; CC Q3LI72; Q8N831: TSPYL6; NbExp=3; IntAct=EBI-1048945, EBI-12023322; CC Q3LI72; Q9UHD9: UBQLN2; NbExp=3; IntAct=EBI-1048945, EBI-947187; CC Q3LI72; Q08AM6: VAC14; NbExp=6; IntAct=EBI-1048945, EBI-2107455; CC Q3LI72; Q14119: VEZF1; NbExp=3; IntAct=EBI-1048945, EBI-11980193; CC Q3LI72; A5D8V6: VPS37C; NbExp=3; IntAct=EBI-1048945, EBI-2559305; CC Q3LI72; A0A0C4DGF1: ZBTB32; NbExp=5; IntAct=EBI-1048945, EBI-10188476; CC Q3LI72; Q15915: ZIC1; NbExp=3; IntAct=EBI-1048945, EBI-11963196; CC Q3LI72; Q96IQ9: ZNF414; NbExp=5; IntAct=EBI-1048945, EBI-744257; CC -!- SIMILARITY: Belongs to the KRTAP type 19 family. {ECO:0000305}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AB096946; BAE46361.1; -; mRNA. DR EMBL; BC100836; AAI00837.1; -; mRNA. DR EMBL; BC100837; AAI00838.1; -; mRNA. DR EMBL; BC100838; AAI00839.1; -; mRNA. DR EMBL; BC100839; AAI00840.1; -; mRNA. DR EMBL; BC113020; AAI13021.1; -; mRNA. DR EMBL; BC113021; AAI13022.1; -; mRNA. DR CCDS; CCDS13597.1; -. DR RefSeq; NP_853642.1; NM_181611.1. DR AlphaFoldDB; Q3LI72; -. DR BioGRID; 130655; 103. DR IntAct; Q3LI72; 98. DR STRING; 9606.ENSP00000334985; -. DR iPTMnet; Q3LI72; -. DR PhosphoSitePlus; Q3LI72; -. DR BioMuta; KRTAP19-5; -. DR DMDM; 88909171; -. DR MassIVE; Q3LI72; -. DR PaxDb; Q3LI72; -. DR PeptideAtlas; Q3LI72; -. DR ProteomicsDB; 61770; -. DR Antibodypedia; 76478; 28 antibodies from 5 providers. DR DNASU; 337972; -. DR Ensembl; ENST00000334151.3; ENSP00000334985.2; ENSG00000186977.3. DR GeneID; 337972; -. DR KEGG; hsa:337972; -. DR MANE-Select; ENST00000334151.3; ENSP00000334985.2; NM_181611.3; NP_853642.1. DR UCSC; uc011ada.3; human. DR AGR; HGNC:18940; -. DR CTD; 337972; -. DR GeneCards; KRTAP19-5; -. DR HGNC; HGNC:18940; KRTAP19-5. DR HPA; ENSG00000186977; Tissue enriched (skin). DR neXtProt; NX_Q3LI72; -. DR PharmGKB; PA134992782; -. DR VEuPathDB; HostDB:ENSG00000186977; -. DR eggNOG; ENOG502TDP7; Eukaryota. DR GeneTree; ENSGT00940000165160; -. DR HOGENOM; CLU_184630_0_0_1; -. DR OMA; YGMAAIR; -. DR PathwayCommons; Q3LI72; -. DR Reactome; R-HSA-6805567; Keratinization. DR SignaLink; Q3LI72; -. DR BioGRID-ORCS; 337972; 5 hits in 1091 CRISPR screens. DR GenomeRNAi; 337972; -. DR Pharos; Q3LI72; Tdark. DR PRO; PR:Q3LI72; -. DR Proteomes; UP000005640; Chromosome 21. DR RNAct; Q3LI72; protein. DR Bgee; ENSG00000186977; Expressed in sural nerve and 31 other tissues. DR GO; GO:0005829; C:cytosol; TAS:Reactome. DR GO; GO:0005882; C:intermediate filament; IEA:UniProtKB-KW. DR InterPro; IPR021743; KRTAP_type6/8/16/19/20/21. DR PANTHER; PTHR38140; KERATIN-ASSOCIATED PROTEIN 19-3-RELATED; 1. DR PANTHER; PTHR38140:SF4; KERATIN-ASSOCIATED PROTEIN 19-5; 1. DR Pfam; PF11759; KRTAP; 1. PE 1: Evidence at protein level; KW Keratin; Reference proteome; Repeat. FT CHAIN 1..72 FT /note="Keratin-associated protein 19-5" FT /id="PRO_0000223907" SQ SEQUENCE 72 AA; 7624 MW; EEBDA9D9506BCCD7 CRC64; MNYYGNYYGG LGYGYGGFDD LGYGYGCGCG SFRRLGYGGG YGGYGYGSGF GGYGYRSCRP SCYGGYGFSG FY //