ID Q3L887_MYCS2 Unreviewed; 611 AA. AC Q3L887; A0QPI1; DT 08-NOV-2005, integrated into UniProtKB/TrEMBL. DT 08-NOV-2005, sequence version 1. DT 07-SEP-2016, entry version 85. DE SubName: Full=Acyl-CoA dehydrogenase {ECO:0000313|EMBL:AFP36877.1}; DE EC=1.3.8.1 {ECO:0000313|EMBL:AFP36877.1}; DE SubName: Full=Acyl-coA-dehydrogenase {ECO:0000313|EMBL:AAU04876.1}; GN Name=fadE5 {ECO:0000313|EMBL:AAU04876.1}; GN OrderedLocusNames=MSMEG_0406 {ECO:0000313|EMBL:ABK75628.1}, MSMEI_0396 GN {ECO:0000313|EMBL:AFP36877.1}; OS Mycobacterium smegmatis (strain ATCC 700084 / mc(2)155). OC Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae; OC Mycobacterium. OX NCBI_TaxID=246196 {ECO:0000313|EMBL:AAU04876.1}; RN [1] {ECO:0000313|EMBL:AAU04876.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=MC2 155 {ECO:0000313|EMBL:AAU04876.1}; RX PubMed=16194230; DOI=10.1111/j.1365-2958.2005.04847.x; RA Sonden B., Kocincova D., Deshayes C., Euphrasie D., Rhayat L., RA Laval F., Frehel C., Daffe M., Etienne G., Reyrat J.M.; RT "Gap, a mycobacterial specific integral membrane protein, is required RT for glycolipid transport to the cell surface."; RL Mol. Microbiol. 58:426-440(2005). RN [2] {ECO:0000313|EMBL:AAU04876.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=MC2 155 {ECO:0000313|EMBL:AAU04876.1}; RA Deshayes C., Kocincova D., Etienne G., Reyrat J.-M.; RL Submitted (JAN-2006) to the EMBL/GenBank/DDBJ databases. RN [3] {ECO:0000313|EMBL:ABK75628.1, ECO:0000313|Proteomes:UP000000757} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=ATCC 700084 / mc(2)155 {ECO:0000313|Proteomes:UP000000757}, and RC MC2 155 {ECO:0000313|EMBL:ABK75628.1}; RA Fleischmann R.D., Dodson R.J., Haft D.H., Merkel J.S., Nelson W.C., RA Fraser C.M.; RL Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases. RN [4] {ECO:0000313|EMBL:AFP36877.1, ECO:0000313|Proteomes:UP000006158} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=ATCC 700084 / mc(2)155 {ECO:0000313|Proteomes:UP000006158}, and RC MC2 155 {ECO:0000313|EMBL:AFP36877.1}; RX PubMed=17295914; DOI=10.1186/gb-2007-8-2-r20; RA Deshayes C., Perrodou E., Gallien S., Euphrasie D., Schaeffer C., RA Van-Dorsselaer A., Poch O., Lecompte O., Reyrat J.M.; RT "Interrupted coding sequences in Mycobacterium smegmatis: authentic RT mutations or sequencing errors?"; RL Genome Biol. 8:R20.1-R20.9(2007). RN [5] {ECO:0000313|EMBL:AFP36877.1, ECO:0000313|Proteomes:UP000006158} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=ATCC 700084 / mc(2)155 {ECO:0000313|Proteomes:UP000006158}; RX PubMed=18955433; DOI=10.1101/gr.081901.108; RA Gallien S., Perrodou E., Carapito C., Deshayes C., Reyrat J.M., RA Van Dorsselaer A., Poch O., Schaeffer C., Lecompte O.; RT "Ortho-proteogenomics: multiple proteomes investigation through RT orthology and a new MS-based protocol."; RL Genome Res. 19:128-135(2009). CC -!- COFACTOR: CC Name=FAD; Xref=ChEBI:CHEBI:57692; CC Evidence={ECO:0000256|RuleBase:RU362125}; CC -!- SIMILARITY: Belongs to the acyl-CoA dehydrogenase family. CC {ECO:0000256|RuleBase:RU362125}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AY439015; AAU04876.1; -; Genomic_DNA. DR EMBL; CP000480; ABK75628.1; -; Genomic_DNA. DR EMBL; CP001663; AFP36877.1; -; Genomic_DNA. DR RefSeq; WP_011726920.1; NZ_CP009494.1. DR RefSeq; YP_884819.1; NC_008596.1. DR STRING; 246196.MSMEG_0406; -. DR EnsemblBacteria; ABK75628; ABK75628; MSMEG_0406. DR EnsemblBacteria; AFP36877; AFP36877; MSMEI_0396. DR GeneID; 4534136; -. DR KEGG; msb:LJ00_02020; -. DR KEGG; msg:MSMEI_0396; -. DR KEGG; msm:MSMEG_0406; -. DR PATRIC; 18073280; VBIMycSme59918_0402. DR eggNOG; ENOG4105CSU; Bacteria. DR eggNOG; COG1960; LUCA. DR HOGENOM; HOG000258862; -. DR OMA; LYEGTTH; -. DR OrthoDB; POG091H00BG; -. DR BioCyc; MSME246196:GJ4Y-406-MONOMER; -. DR Proteomes; UP000000757; Chromosome. DR Proteomes; UP000006158; Chromosome. DR GO; GO:0003995; F:acyl-CoA dehydrogenase activity; IEA:InterPro. DR GO; GO:0004085; F:butyryl-CoA dehydrogenase activity; IEA:UniProtKB-EC. DR GO; GO:0050660; F:flavin adenine dinucleotide binding; IEA:UniProtKB-UniRule. DR InterPro; IPR025878; Acyl-CoA_dh-like_C_dom. DR InterPro; IPR020953; Acyl-CoA_DH_N_bac. DR InterPro; IPR006091; Acyl-CoA_Oxase/DH_cen-dom. DR InterPro; IPR009075; AcylCo_DH/oxidase_C. DR InterPro; IPR009100; AcylCoA_DH/oxidase_NM_dom. DR Pfam; PF00441; Acyl-CoA_dh_1; 1. DR Pfam; PF12806; Acyl-CoA_dh_C; 1. DR Pfam; PF02770; Acyl-CoA_dh_M; 1. DR Pfam; PF12418; AcylCoA_DH_N; 1. DR SUPFAM; SSF47203; SSF47203; 1. DR SUPFAM; SSF56645; SSF56645; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000000757, KW ECO:0000313|Proteomes:UP000006158}; KW FAD {ECO:0000256|RuleBase:RU362125}; KW Flavoprotein {ECO:0000256|RuleBase:RU362125}; KW Oxidoreductase {ECO:0000256|RuleBase:RU362125, KW ECO:0000313|EMBL:AFP36877.1}; KW Reference proteome {ECO:0000313|Proteomes:UP000000757}. FT DOMAIN 3 34 AcylCoA_DH_N. {ECO:0000259|Pfam:PF12418}. FT DOMAIN 162 271 Acyl-CoA_dh_M. {ECO:0000259|Pfam: FT PF02770}. FT DOMAIN 288 455 Acyl-CoA_dh_1. {ECO:0000259|Pfam: FT PF00441}. FT DOMAIN 474 607 Acyl-CoA_dh_C. {ECO:0000259|Pfam: FT PF12806}. SQ SEQUENCE 611 AA; 66532 MW; 41D1ABFE887E0206 CRC64; MSHYKSNVRD QVFNLFEVFG VDKVLGADKF SDLDADTARE MLTEIARLAE GPIAESFVEG DRNPPVFDPE THTVTLPEGF KKSMRALFDG GWDKVGLAEH LGGIPMPRAL QWALIEHILG ANPAAYMYAM GPGMSEIFYN NGTDEQKKWA TIAAERGWGA TMVLTEPDAG SDVGAGRTKA VQQPDGTWHI EGVKRFITSA DSDDLFENIM HLVLARPEGA GPGTKGLSLF FVPKFHFDHE TGEIGERNGV FVTNVEHKMG LKVSATCELS LGQHGIPAVG WLVGEVHNGI AQMFDVIEQA RMMVGTKAIA TLSTGYLNAL EYAKERVQGA DMTQMTDKTA PRVTITHHPD VRRSLMTQKA YAEGLRAIYL YTATFQDAEV AQAVHGVDGD LAARVNDLLL PIVKGFGSET AYAKLTESLQ TLGGSGFLQD YPIEQYIRDS KIDSLYEGTT AIQAQDFFFR KIIRDKGQAL AYVAGEIEQF IKNENGNGRL KTERELLATA LADVQGMAAS LTGYLMAAQE DAASIYKVGL GSVRFLMAVG DLLSGWLLAR QAAVAIEKLD AGATGADKSF YEGKIAAASF FAKNMLPLLT STRQIIENLD NDVMELDEAA F //