ID   Q3KP16_MOUSE            Unreviewed;       126 AA.
AC   Q3KP16;
DT   08-NOV-2005, integrated into UniProtKB/TrEMBL.
DT   08-NOV-2005, sequence version 1.
DT   22-JUL-2015, entry version 69.
DE   RecName: Full=P2X purinoceptor {ECO:0000256|RuleBase:RU000681};
GN   Name=P2rx2 {ECO:0000313|EMBL:AAI06964.1, ECO:0000313|MGI:MGI:2665170};
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi;
OC   Muroidea; Muridae; Murinae; Mus; Mus.
OX   NCBI_TaxID=10090 {ECO:0000313|EMBL:AAI06964.1};
RN   [1] {ECO:0000313|EMBL:AAI06964.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=PCR rescued clones {ECO:0000313|EMBL:AAI06964.1};
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RA   Gerhard D.S., Wagner L., Feingold E.A., Shenmen C.M., Grouse L.H.,
RA   Schuler G., Klein S.L., Old S., Rasooly R., Good P., Guyer M.,
RA   Peck A.M., Derge J.G., Lipman D., Collins F.S., Jang W., Sherry S.,
RA   Feolo M., Misquitta L., Lee E., Rotmistrovsky K., Greenhut S.F.,
RA   Schaefer C.F., Buetow K., Bonner T.I., Haussler D., Kent J.,
RA   Kiekhaus M., Furey T., Brent M., Prange C., Schreiber K., Shapiro N.,
RA   Bhat N.K., Hopkins R.F., Hsie F., Driscoll T., Soares M.B.,
RA   Casavant T.L., Scheetz T.E., Brown-stein M.J., Usdin T.B.,
RA   Toshiyuki S., Carninci P., Piao Y., Dudekula D.B., Ko M.S.,
RA   Kawakami K., Suzuki Y., Sugano S., Gruber C.E., Smith M.R.,
RA   Simmons B., Moore T., Waterman R., Johnson S.L., Ruan Y., Wei C.L.,
RA   Mathavan S., Gunaratne P.H., Wu J., Garcia A.M., Hulyk S.W., Fuh E.,
RA   Yuan Y., Sneed A., Kowis C., Hodgson A., Muzny D.M., McPherson J.,
RA   Gibbs R.A., Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S.,
RA   Sanchez A., Whiting M., Madari A., Young A.C., Wetherby K.D.,
RA   Granite S.J., Kwong P.N., Brinkley C.P., Pearson R.L., Bouffard G.G.,
RA   Blakesly R.W., Green E.D., Dickson M.C., Rodriguez A.C., Grimwood J.,
RA   Schmutz J., Myers R.M., Butterfield Y.S., Griffith M., Griffith O.L.,
RA   Krzywinski M.I., Liao N., Morin R., Morrin R., Palmquist D.,
RA   Petrescu A.S., Skalska U., Smailus D.E., Stott J.M., Schnerch A.,
RA   Schein J.E., Jones S.J., Holt R.A., Baross A., Marra M.A., Clifton S.,
RA   Makowski K.A., Bosak S., Malek J.;
RT   "The status, quality, and expansion of the NIH full-length cDNA
RT   project: the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|RuleBase:RU000681};
CC       Multi-pass membrane protein {ECO:0000256|RuleBase:RU000681}.
CC   -!- SIMILARITY: Belongs to the P2X receptor family.
CC       {ECO:0000256|RuleBase:RU000681}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; BC106963; AAI06964.1; -; mRNA.
DR   UniGene; Mm.55948; -.
DR   STRING; 10090.ENSMUSP00000054233; -.
DR   MGI; MGI:2665170; P2rx2.
DR   Bgee; Q3KP16; -.
DR   ExpressionAtlas; Q3KP16; baseline and differential.
DR   GO; GO:0016324; C:apical plasma membrane; ISO:MGI.
DR   GO; GO:0005639; C:integral component of nuclear inner membrane; IBA:GO_Central.
DR   GO; GO:0005887; C:integral component of plasma membrane; ISO:MGI.
DR   GO; GO:0005622; C:intracellular; IDA:MGI.
DR   GO; GO:0005886; C:plasma membrane; IDA:MGI.
DR   GO; GO:0043235; C:receptor complex; ISO:MGI.
DR   GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR   GO; GO:0004931; F:extracellular ATP-gated cation channel activity; IDA:MGI.
DR   GO; GO:0042802; F:identical protein binding; ISO:MGI.
DR   GO; GO:0001614; F:purinergic nucleotide receptor activity; IBA:GO_Central.
DR   GO; GO:0048266; P:behavioral response to pain; IMP:MGI.
DR   GO; GO:0003029; P:detection of hypoxic conditions in blood by carotid body chemoreceptor signaling; IMP:MGI.
DR   GO; GO:0007528; P:neuromuscular junction development; IMP:MGI.
DR   GO; GO:0007274; P:neuromuscular synaptic transmission; IMP:MGI.
DR   GO; GO:0030432; P:peristalsis; IMP:MGI.
DR   GO; GO:0051260; P:protein homooligomerization; ISO:MGI.
DR   GO; GO:0035590; P:purinergic nucleotide receptor signaling pathway; IBA:GOC.
DR   GO; GO:0033198; P:response to ATP; IMP:MGI.
DR   GO; GO:0009743; P:response to carbohydrate; IMP:MGI.
DR   GO; GO:0001666; P:response to hypoxia; IMP:MGI.
DR   GO; GO:0010033; P:response to organic substance; IMP:MGI.
DR   GO; GO:0007605; P:sensory perception of sound; ISO:MGI.
DR   GO; GO:0050909; P:sensory perception of taste; IGI:MGI.
DR   GO; GO:0048741; P:skeletal muscle fiber development; IMP:MGI.
DR   GO; GO:0007268; P:synaptic transmission; IMP:MGI.
DR   GO; GO:0014832; P:urinary bladder smooth muscle contraction; IMP:MGI.
DR   Gene3D; 2.60.490.10; -; 1.
DR   InterPro; IPR003045; P2X2_purnocptor.
DR   InterPro; IPR027309; P2X_extracellular_dom.
DR   InterPro; IPR001429; P2X_purnocptor.
DR   PANTHER; PTHR10125; PTHR10125; 1.
DR   PANTHER; PTHR10125:SF4; PTHR10125:SF4; 1.
DR   Pfam; PF00864; P2X_receptor; 1.
DR   PRINTS; PR01307; P2XRECEPTOR.
PE   2: Evidence at transcript level;
KW   Ion channel {ECO:0000256|RuleBase:RU000681};
KW   Ion transport {ECO:0000256|RuleBase:RU000681};
KW   Receptor {ECO:0000256|RuleBase:RU000681};
KW   Transport {ECO:0000256|RuleBase:RU000681}.
SQ   SEQUENCE   126 AA;  14021 MW;  A9783F6CFAE916D6 CRC64;
     MSEHKVWDVE EYVKPPEGGS VVSIITRIEV TPSQTLGTCP ESMRVHSSTC HLDDDCVAGQ
     LDMQGNGIRT GRCVPYYHGD SKTCEVSAWC PVEDGTSENH FLGKMAPNFT ILIKNSIHYP
     KFKFSK
//