ID UBIA_BURP1 Reviewed; 287 AA. AC Q3JNX1; DT 28-NOV-2006, integrated into UniProtKB/Swiss-Prot. DT 28-NOV-2006, sequence version 2. DT 11-DEC-2019, entry version 77. DE RecName: Full=4-hydroxybenzoate octaprenyltransferase {ECO:0000255|HAMAP-Rule:MF_01635}; DE EC=2.5.1.39 {ECO:0000255|HAMAP-Rule:MF_01635}; DE AltName: Full=4-HB polyprenyltransferase {ECO:0000255|HAMAP-Rule:MF_01635}; GN Name=ubiA {ECO:0000255|HAMAP-Rule:MF_01635}; GN OrderedLocusNames=BURPS1710b_3361; OS Burkholderia pseudomallei (strain 1710b). OC Bacteria; Proteobacteria; Betaproteobacteria; Burkholderiales; OC Burkholderiaceae; Burkholderia; pseudomallei group. OX NCBI_TaxID=320372; RN [1] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=1710b; RA Woods D.E., Nierman W.C.; RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases. CC -!- FUNCTION: Catalyzes the prenylation of para-hydroxybenzoate (PHB) with CC an all-trans polyprenyl group. Mediates the second step in the final CC reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the CC condensation of the polyisoprenoid side chain with PHB, generating the CC first membrane-bound Q intermediate 3-octaprenyl-4-hydroxybenzoate. CC {ECO:0000255|HAMAP-Rule:MF_01635}. CC -!- CATALYTIC ACTIVITY: CC Reaction=4-hydroxybenzoate + all-trans-octaprenyl diphosphate = 4- CC hydroxy-3-all-trans-octaprenylbenzoate + diphosphate; CC Xref=Rhea:RHEA:27782, ChEBI:CHEBI:1617, ChEBI:CHEBI:17879, CC ChEBI:CHEBI:33019, ChEBI:CHEBI:57711; EC=2.5.1.39; CC Evidence={ECO:0000255|HAMAP-Rule:MF_01635}; CC -!- COFACTOR: CC Name=Mg(2+); Xref=ChEBI:CHEBI:18420; CC Evidence={ECO:0000255|HAMAP-Rule:MF_01635}; CC -!- PATHWAY: Cofactor biosynthesis; ubiquinone biosynthesis. CC {ECO:0000255|HAMAP-Rule:MF_01635}. CC -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000255|HAMAP- CC Rule:MF_01635}; Multi-pass membrane protein {ECO:0000255|HAMAP- CC Rule:MF_01635}. CC -!- SIMILARITY: Belongs to the UbiA prenyltransferase family. CC {ECO:0000255|HAMAP-Rule:MF_01635}. CC -!- SEQUENCE CAUTION: CC Sequence=ABA47892.1; Type=Erroneous initiation; Evidence={ECO:0000305}; CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; CP000124; ABA47892.1; ALT_INIT; Genomic_DNA. DR EnsemblBacteria; ABA47892; ABA47892; BURPS1710b_3361. DR KEGG; bpm:BURPS1710b_3361; -. DR HOGENOM; HOG000003696; -. DR KO; K03179; -. DR UniPathway; UPA00232; -. DR Proteomes; UP000002700; Chromosome I. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell. DR GO; GO:0002083; F:4-hydroxybenzoate decaprenyltransferase activity; IEA:UniProtKB-EC. DR GO; GO:0047293; F:4-hydroxybenzoate nonaprenyltransferase activity; IEA:UniProtKB-EC. DR GO; GO:0008412; F:4-hydroxybenzoate octaprenyltransferase activity; IEA:UniProtKB-UniRule. DR GO; GO:0006744; P:ubiquinone biosynthetic process; IEA:UniProtKB-UniRule. DR HAMAP; MF_01635; UbiA; 1. DR InterPro; IPR006370; HB_polyprenyltransferase-like. DR InterPro; IPR039653; Prenyltransferase. DR InterPro; IPR000537; UbiA_prenyltransferase. DR InterPro; IPR030470; UbiA_prenylTrfase_CS. DR PANTHER; PTHR11048; PTHR11048; 1. DR Pfam; PF01040; UbiA; 1. DR TIGRFAMs; TIGR01474; ubiA_proteo; 1. DR PROSITE; PS00943; UBIA; 1. PE 3: Inferred from homology; KW Cell inner membrane; Cell membrane; Magnesium; Membrane; Transferase; KW Transmembrane; Transmembrane helix; Ubiquinone biosynthesis. FT CHAIN 1..287 FT /note="4-hydroxybenzoate octaprenyltransferase" FT /id="PRO_0000262784" FT TRANSMEM 30..50 FT /note="Helical" FT /evidence="ECO:0000255|HAMAP-Rule:MF_01635" FT TRANSMEM 92..112 FT /note="Helical" FT /evidence="ECO:0000255|HAMAP-Rule:MF_01635" FT TRANSMEM 133..153 FT /note="Helical" FT /evidence="ECO:0000255|HAMAP-Rule:MF_01635" FT TRANSMEM 158..178 FT /note="Helical" FT /evidence="ECO:0000255|HAMAP-Rule:MF_01635" FT TRANSMEM 207..227 FT /note="Helical" FT /evidence="ECO:0000255|HAMAP-Rule:MF_01635" FT TRANSMEM 232..252 FT /note="Helical" FT /evidence="ECO:0000255|HAMAP-Rule:MF_01635" FT TRANSMEM 266..286 FT /note="Helical" FT /evidence="ECO:0000255|HAMAP-Rule:MF_01635" SQ SEQUENCE 287 AA; 31688 MW; DD14493085F58D33 CRC64; MLARFPLYLR LIRMDKPIGS LLLLWPTLNA LWIASDGHPA PSLVVIFALG TLLMRSAGCA INDYADRDFD RHVKRTAERP LTSGKIRAWE AIAIAVGLAL VSFLLILPLN GLTKELSVVA VFVAATYPFM KRFFAIPQAY LGIAFGFGIP MAFAAVQDTV PMIAWAMLAA NVFWSVAYDT AYAMVDRDDD LKIGMRTSAI TFGRHDVLAI MLCYAAMLGI YVWLGAALHF GWPYWAGWAA AAGCSIYHYT LIKDRERMAC FAAFRHNNWL GGVLFAGIAA HYALAVR //