ID   TPMT_LYNRU              Reviewed;         245 AA.
AC   Q3BCR9;
DT   20-DEC-2005, integrated into UniProtKB/Swiss-Prot.
DT   22-NOV-2005, sequence version 1.
DT   08-APR-2008, entry version 17.
DE   Thiopurine S-methyltransferase (EC 2.1.1.67) (Thiopurine
DE   methyltransferase).
GN   Name=TPMT;
OS   Lynx rufus (Bobcat) (Felis rufus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Laurasiatheria; Carnivora; Feliformia; Felidae;
OC   Felinae; Lynx.
OX   NCBI_TaxID=61384;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=16220112;
RA   Salavaggione O.E., Wang L., Wiepert M., Yee V.C., Weinshilboum R.M.;
RT   "Thiopurine S-methyltransferase pharmacogenetics: variant allele
RT   functional and comparative genomics.";
RL   Pharmacogenet. Genomics 15:801-815(2005).
CC   -!- FUNCTION: Catalyzes the S-methylation of thiopurine drugs such as
CC       6-mercaptopurine.
CC   -!- CATALYTIC ACTIVITY: S-adenosyl-L-methionine + a thiopurine = S-
CC       adenosyl-L-homocysteine + a thiopurine S-methylether.
CC   -!- SUBUNIT: Monomer (By similarity).
CC   -!- SUBCELLULAR LOCATION: Cytoplasm.
CC   -!- SIMILARITY: Belongs to the methyltransferase superfamily. TPMT
CC       family.
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DR   EMBL; AY819776; AAX37638.1; -; mRNA.
DR   SMR; Q3BCR9; 17-245.
DR   InterPro; IPR008854; Thiopurine_S-MeTrfase.
DR   InterPro; IPR016822; Thiopurine_S-MeTrfase_sub.
DR   Pfam; PF05724; TPMT; 1.
DR   PIRSF; PIRSF023956; Thiopurine_S-methyltransferase; 1.
PE   2: Evidence at transcript level;
KW   Cytoplasm; Methyltransferase; S-adenosyl-L-methionine; Transferase.
FT   CHAIN         1    245       Thiopurine S-methyltransferase.
FT                                /FTId=PRO_0000220104.
FT   BINDING      33     33       S-adenosyl-L-methionine (By similarity).
FT   BINDING      69     69       S-adenosyl-L-methionine; via carbonyl
FT                                oxygen (By similarity).
FT   BINDING      90     90       S-adenosyl-L-methionine (By similarity).
FT   BINDING     152    152       S-adenosyl-L-methionine (By similarity).
SQ   SEQUENCE   245 AA;  28333 MW;  E233F17546F11D1C CRC64;
     MDDTSTLIDV KEYPDTEVQK NRVLTLEEWR EKWVDGKIGF HQEQGHQLLK KHLDTFLKGE
     NVLRVFFPLC GKAVEMKWFA DRGHCVVGVE ISELGIREFF TEQNLSYSEE PIMEIPGAKV
     FKSSSGNISL YCCNLFDLPR VNIGKFDRIW DRGALVAVNP GDRKCYTDIM LSLTRKGFRY
     LLAVLSYDPT KHPGPPFYVP DAEIKNLFGS TCNIHCLEKV DVFEERHKSW GIDYIVEKLY
     LLTEK
//