ID   Q38KA8_LIMRT            Unreviewed;       142 AA.
AC   Q38KA8;
DT   22-NOV-2005, integrated into UniProtKB/TrEMBL.
DT   22-NOV-2005, sequence version 1.
DT   24-JUL-2024, entry version 103.
DE   RecName: Full=Transcriptional regulator MraZ {ECO:0000256|ARBA:ARBA00013860, ECO:0000256|HAMAP-Rule:MF_01008};
GN   Name=mraZ {ECO:0000256|HAMAP-Rule:MF_01008,
GN   ECO:0000313|EMBL:AWD62056.1};
GN   ORFNames=B1A73_01835 {ECO:0000313|EMBL:WOZ74555.1}, B5D07_03445
GN   {ECO:0000313|EMBL:OPG88801.1}, B5F04_01855
GN   {ECO:0000313|EMBL:OUP90046.1}, B5G22_01965
GN   {ECO:0000313|EMBL:OUN49689.1}, BHL82_02460
GN   {ECO:0000313|EMBL:OTA81488.1}, BHL83_02580
GN   {ECO:0000313|EMBL:OTA93112.1}, C5O77_01245
GN   {ECO:0000313|EMBL:RMX26278.1}, DB325_06220
GN   {ECO:0000313|EMBL:PTV03742.1}, DKZ22_01160
GN   {ECO:0000313|EMBL:PWT43219.1}, GIX73_07620
GN   {ECO:0000313|EMBL:MRI04082.1}, GIX74_04955
GN   {ECO:0000313|EMBL:MRI07756.1}, GIX77_01355
GN   {ECO:0000313|EMBL:MRH79434.1}, GIX83_03760
GN   {ECO:0000313|EMBL:MRG68961.1}, HHK02_03525
GN   {ECO:0000313|EMBL:QLQ62390.1}, JVX33_09700
GN   {ECO:0000313|EMBL:MCH5358507.1}, lr1628 {ECO:0000313|EMBL:ABB02577.1},
GN   LR3_05510 {ECO:0000313|EMBL:KEK16359.1}, LRLP16767_LR202_02237
GN   {ECO:0000313|EMBL:CUR42627.1}, LWHH1689_0737
GN   {ECO:0000313|EMBL:AWD62056.1}, PPJ95_08700
GN   {ECO:0000313|EMBL:MDC6077628.1};
OS   Limosilactobacillus reuteri (Lactobacillus reuteri).
OC   Bacteria; Bacillota; Bacilli; Lactobacillales; Lactobacillaceae;
OC   Limosilactobacillus.
OX   NCBI_TaxID=1598 {ECO:0000313|EMBL:ABB02577.1};
RN   [1] {ECO:0000313|EMBL:ABB02577.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=ATCC 55730 {ECO:0000313|EMBL:ABB02577.1};
RX   PubMed=17449683; DOI=10.1128/AEM.01502-06;
RA   Wall T., Bath K., Britton R.A., Jonsson H., Versalovic J., Roos S.;
RT   "The early response to acid shock in Lactobacillus reuteri involves the
RT   ClpL chaperone and a putative cell wall-altering esterase.";
RL   Appl. Environ. Microbiol. 73:3924-3935(2007).
RN   [2] {ECO:0000313|EMBL:ABB02577.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=ATCC 55730 {ECO:0000313|EMBL:ABB02577.1};
RX   PubMed=18245259; DOI=10.1128/AEM.02259-07;
RA   Whitehead K., Versalovic J., Roos S., Britton R.A.;
RT   "Genomic and genetic characterization of the bile stress response of
RT   probiotic Lactobacillus reuteri ATCC 55730.";
RL   Appl. Environ. Microbiol. 74:1812-1819(2008).
RN   [3] {ECO:0000313|EMBL:KEK16359.1, ECO:0000313|Proteomes:UP000027731}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=LTH2584 {ECO:0000313|EMBL:KEK16359.1,
RC   ECO:0000313|Proteomes:UP000027731};
RA   Lin X., Duar R., Walter J., Gaenzle M.;
RT   "Genetic determinant of reutericyclin biosynthesis of Lactobacillus
RT   reuteri.";
RL   Submitted (JUN-2014) to the EMBL/GenBank/DDBJ databases.
RN   [4] {ECO:0000313|Proteomes:UP000235484}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=20-2 {ECO:0000313|Proteomes:UP000235484};
RA   Crossman L.C.;
RL   Submitted (OCT-2015) to the EMBL/GenBank/DDBJ databases.
RN   [5] {ECO:0000313|EMBL:CUR42627.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=20-2 {ECO:0000313|EMBL:CUR42627.1};
RA   Gilbert D.G.;
RL   Submitted (OCT-2015) to the EMBL/GenBank/DDBJ databases.
RN   [6] {ECO:0000313|EMBL:OTA81488.1, ECO:0000313|Proteomes:UP000194286}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=KLR3005 {ECO:0000313|EMBL:OTA81488.1,
RC   ECO:0000313|Proteomes:UP000194286};
RA   Lee J.-Y., Kim E.B., Choi Y.-J.;
RT   "Lactobacillus reuteri KLR3005, genome sequencing and assembly.";
RL   Submitted (SEP-2016) to the EMBL/GenBank/DDBJ databases.
RN   [7] {ECO:0000313|EMBL:OTA93112.1, ECO:0000313|Proteomes:UP000194219}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=KLR3006 {ECO:0000313|EMBL:OTA93112.1,
RC   ECO:0000313|Proteomes:UP000194219};
RA   Lee J.-Y., Kim E.B., Choi Y.-J.;
RT   "Lactobacillus reuteri KLR3006, genome sequencing and assembly.";
RL   Submitted (SEP-2016) to the EMBL/GenBank/DDBJ databases.
RN   [8] {ECO:0000313|EMBL:OPG88801.1, ECO:0000313|Proteomes:UP000189795}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CECT8605 {ECO:0000313|EMBL:OPG88801.1,
RC   ECO:0000313|Proteomes:UP000189795};
RA   Sanudo A.I., Olivares M., Banuelos O.;
RT   "Antibiotic resistance of probiotic microorganisms.";
RL   Submitted (MAR-2017) to the EMBL/GenBank/DDBJ databases.
RN   [9] {ECO:0000313|Proteomes:UP000195868, ECO:0000313|Proteomes:UP000196467}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=An166 {ECO:0000313|Proteomes:UP000196467}, and An71
RC   {ECO:0000313|Proteomes:UP000195868};
RA   Medvecky M., Cejkova D., Polansky O., Karasova D., Kubasova T., Cizek A.,
RA   Rychlik I.;
RT   "Function of individual gut microbiota members based on whole genome
RT   sequencing of pure cultures obtained from chicken caecum.";
RL   Submitted (APR-2017) to the EMBL/GenBank/DDBJ databases.
RN   [10] {ECO:0000313|EMBL:OUN49689.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=An166 {ECO:0000313|EMBL:OUP90046.1}, and An71
RC   {ECO:0000313|EMBL:OUN49689.1};
RX   PubMed=30064352;
RA   Medvecky M., Cejkova D., Polansky O., Karasova D., Kubasova T., Cizek A.,
RA   Rychlik I.;
RT   "Whole genome sequencing and function prediction of 133 gut anaerobes
RT   isolated from chicken caecum in pure cultures.";
RL   BMC Genomics 19:0-561(2018).
RN   [11] {ECO:0000313|EMBL:PWT43219.1, ECO:0000313|Proteomes:UP000245980}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=LR10 {ECO:0000313|EMBL:PWT43219.1,
RC   ECO:0000313|Proteomes:UP000245980};
RA   Zhao J.;
RT   "Comparative Genomics of the Herbivore Gut Symbiont Lactobacillus reuteri
RT   Reveals Genetic Diversity and Lifestyle Adaptation.";
RL   Front. Microbiol. 0:0-0(2018).
RN   [12] {ECO:0000313|EMBL:PTV03742.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=DS12_10 {ECO:0000313|EMBL:PTV03742.1};
RX   PubMed=29954914;
RA   Gangiredla J., Barnaba T.J., Mammel M.K., Lacher D.W., Elkins C.A.,
RA   Lampel K.A., Whitehouse C.A., Tartera C.;
RT   "Fifty-Six Draft Genome Sequences of 10 Lactobacillus Species from 22
RT   Commercial Dietary Supplements.";
RL   Genome Announc. 6:e00621-18(2018).
RN   [13] {ECO:0000313|EMBL:RMX26278.1, ECO:0000313|Proteomes:UP000276940}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=R2lc {ECO:0000313|EMBL:RMX26278.1,
RC   ECO:0000313|Proteomes:UP000276940};
RA   Ozcam M., Roos S., Van Pijkeren J.P.;
RT   "The gut symbionts Lactobacillus reuteri R2lc and 2010 encode a polyketide
RT   synthase cluster that activates the mammalian aryl-hydrocarbon receptor.";
RL   J Appl Environ Microbiol 0:0-0(2018).
RN   [14] {ECO:0000313|EMBL:AWD62056.1, ECO:0000313|Proteomes:UP000244369}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=WHH1689 {ECO:0000313|EMBL:AWD62056.1,
RC   ECO:0000313|Proteomes:UP000244369};
RA   Chen S., Chen L., Chen L., Li Y.;
RT   "Complete Genome Sequence of the Chinese traditional Highland Barley wine
RT   Isolate Lactobacillus reuteri WHH1689.";
RL   Submitted (MAR-2018) to the EMBL/GenBank/DDBJ databases.
RN   [15] {ECO:0000313|Proteomes:UP000244083}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DS12_10 {ECO:0000313|Proteomes:UP000244083};
RA   Gangiredla J., Barnaba T.J., Mammel M.K., Lacher D.W., Elkins C.A.,
RA   Lampel K.A., Whitehouse C.A., Tartera C.;
RT   "Draft Genome Sequences of 10 Lactobacillus Species from 22 Commercial
RT   Probiotic Products.";
RL   Submitted (APR-2018) to the EMBL/GenBank/DDBJ databases.
RN   [16] {ECO:0000313|EMBL:PWT43219.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=LR10 {ECO:0000313|EMBL:PWT43219.1};
RA   Peng X.Y., Xu Y.F., Luo D., Yu J., Gu J.Y.;
RL   Submitted (MAY-2018) to the EMBL/GenBank/DDBJ databases.
RN   [17] {ECO:0000313|Proteomes:UP000430686, ECO:0000313|Proteomes:UP000430985}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CR {ECO:0000313|EMBL:MRH79434.1,
RC   ECO:0000313|Proteomes:UP000470878}, L1600-1
RC   {ECO:0000313|EMBL:MRI04082.1, ECO:0000313|Proteomes:UP000431048}, N2J
RC   {ECO:0000313|EMBL:MRI07756.1, ECO:0000313|Proteomes:UP000430686}, and
RC   Rat19 {ECO:0000313|EMBL:MRG68961.1,
RC   ECO:0000313|Proteomes:UP000430985};
RA   Zhang S., Ozcam M., Van Pijkeren J.P.;
RT   "Draft genome sequence of 12 host-associated Lactobacillus reuteri rodent
RT   strains.";
RL   Submitted (NOV-2019) to the EMBL/GenBank/DDBJ databases.
RN   [18] {ECO:0000313|EMBL:QLQ62390.1, ECO:0000313|Proteomes:UP000510868}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CNEI-KCA3 {ECO:0000313|EMBL:QLQ62390.1,
RC   ECO:0000313|Proteomes:UP000510868};
RA   Anukam K.C., Ibezim C.N., BeecK W.V., Allonsius C., Broek M.D.,
RA   Tuyaerts I., Attama A., Esimone C.O., Lebeer S.;
RT   "Genome sequence of Lactobacillus reuteri CNEI-KCA3 isolated from the
RT   faeces of a reared-broiler chicken, South-East Nigeria, reveals presence of
RT   CRISPR arrays.";
RL   Submitted (JUL-2020) to the EMBL/GenBank/DDBJ databases.
RN   [19] {ECO:0000313|EMBL:MCH5358507.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=BR13-C2 {ECO:0000313|EMBL:MCH5358507.1};
RA   Swartwout B.K.;
RL   Submitted (FEB-2021) to the EMBL/GenBank/DDBJ databases.
RN   [20] {ECO:0000313|EMBL:MDC6077628.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=92071 {ECO:0000313|EMBL:MDC6077628.1};
RA   Gao L., Cho G.-S., Brinks E., Pichner R., Franz C.M.A.P.;
RT   "Draft Genome Sequences of three Lactobacillus strains investigated for B
RT   vitamins.";
RL   Submitted (JAN-2023) to the EMBL/GenBank/DDBJ databases.
RN   [21] {ECO:0000313|EMBL:MCH5358507.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=BR13-C2 {ECO:0000313|EMBL:MCH5358507.1};
RA   Lee G., Mu Q., Abdelhamid L., Cabana-Puig X., Edwards M.R., Oh J.,
RA   Hardin K., Testerman J., Reilly C.M., Van Pijkeren J.-P., Leeth C.,
RA   Luo X.M.;
RT   "Strain variability of Limosilactobacillus reuteri mediates IgA induction
RT   through control of B cell differentiation by TLR2.";
RL   Submitted (APR-2023) to the EMBL/GenBank/DDBJ databases.
RN   [22] {ECO:0000313|EMBL:WOZ74555.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=MD IIE-43 {ECO:0000313|EMBL:WOZ74555.1};
RA   Karlyshev A.;
RT   "Complete genome sequence of Lactobacillus reuteri MD IIE-43.";
RL   Submitted (OCT-2023) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBUNIT: Forms oligomers. {ECO:0000256|HAMAP-Rule:MF_01008}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, nucleoid {ECO:0000256|HAMAP-
CC       Rule:MF_01008}.
CC   -!- SIMILARITY: Belongs to the MraZ family. {ECO:0000256|HAMAP-
CC       Rule:MF_01008}.
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DR   EMBL; DQ219972; ABB02577.1; -; Genomic_DNA.
DR   EMBL; CP027805; AWD62056.1; -; Genomic_DNA.
DR   EMBL; LN887693; CUR42627.1; -; Genomic_DNA.
DR   EMBL; JOSX01000007; KEK16359.1; -; Genomic_DNA.
DR   EMBL; JAFFPO010000044; MCH5358507.1; -; Genomic_DNA.
DR   EMBL; JAQOWD010000122; MDC6077628.1; -; Genomic_DNA.
DR   EMBL; WJNE01000009; MRG68961.1; -; Genomic_DNA.
DR   EMBL; WJMX01000001; MRH79434.1; -; Genomic_DNA.
DR   EMBL; WJMY01000022; MRI04082.1; -; Genomic_DNA.
DR   EMBL; WJNC01000007; MRI07756.1; -; Genomic_DNA.
DR   EMBL; MWVS01000041; OPG88801.1; -; Genomic_DNA.
DR   EMBL; MIMU01000139; OTA81488.1; -; Genomic_DNA.
DR   EMBL; MIMV01000011; OTA93112.1; -; Genomic_DNA.
DR   EMBL; NFHN01000005; OUN49689.1; -; Genomic_DNA.
DR   EMBL; NFKV01000005; OUP90046.1; -; Genomic_DNA.
DR   EMBL; QAZN01000010; PTV03742.1; -; Genomic_DNA.
DR   EMBL; QGHT01000003; PWT43219.1; -; Genomic_DNA.
DR   EMBL; CP059275; QLQ62390.1; -; Genomic_DNA.
DR   EMBL; PTLS01000018; RMX26278.1; -; Genomic_DNA.
DR   EMBL; CP137611; WOZ74555.1; -; Genomic_DNA.
DR   RefSeq; WP_003666752.1; NZ_WLWC01000031.1.
DR   GeneID; 77190736; -.
DR   PATRIC; fig|1598.90.peg.199; -.
DR   OMA; ECELDGN; -.
DR   OrthoDB; 9807753at2; -.
DR   Proteomes; UP000027731; Unassembled WGS sequence.
DR   Proteomes; UP000189795; Unassembled WGS sequence.
DR   Proteomes; UP000191051; Chromosome.
DR   Proteomes; UP000194219; Unassembled WGS sequence.
DR   Proteomes; UP000194286; Unassembled WGS sequence.
DR   Proteomes; UP000195868; Unassembled WGS sequence.
DR   Proteomes; UP000196467; Unassembled WGS sequence.
DR   Proteomes; UP000235484; Unassembled WGS sequence.
DR   Proteomes; UP000244083; Unassembled WGS sequence.
DR   Proteomes; UP000244369; Chromosome.
DR   Proteomes; UP000245980; Unassembled WGS sequence.
DR   Proteomes; UP000276940; Unassembled WGS sequence.
DR   Proteomes; UP000430686; Unassembled WGS sequence.
DR   Proteomes; UP000430985; Unassembled WGS sequence.
DR   Proteomes; UP000431048; Unassembled WGS sequence.
DR   Proteomes; UP000470878; Unassembled WGS sequence.
DR   Proteomes; UP000510868; Chromosome.
DR   Proteomes; UP001203130; Unassembled WGS sequence.
DR   Proteomes; UP001215811; Unassembled WGS sequence.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-UniRule.
DR   GO; GO:0009295; C:nucleoid; IEA:UniProtKB-SubCell.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0000976; F:transcription cis-regulatory region binding; IEA:TreeGrafter.
DR   GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR   GO; GO:2000143; P:negative regulation of DNA-templated transcription initiation; IEA:TreeGrafter.
DR   CDD; cd16321; MraZ_C; 1.
DR   CDD; cd16320; MraZ_N; 1.
DR   Gene3D; 3.40.1550.20; Transcriptional regulator MraZ domain; 1.
DR   HAMAP; MF_01008; MraZ; 1.
DR   InterPro; IPR003444; MraZ.
DR   InterPro; IPR035644; MraZ_C.
DR   InterPro; IPR020603; MraZ_dom.
DR   InterPro; IPR035642; MraZ_N.
DR   InterPro; IPR038619; MraZ_sf.
DR   InterPro; IPR007159; SpoVT-AbrB_dom.
DR   InterPro; IPR037914; SpoVT-AbrB_sf.
DR   NCBIfam; TIGR00242; division/cell wall cluster transcriptional repressor MraZ; 1.
DR   PANTHER; PTHR34701; TRANSCRIPTIONAL REGULATOR MRAZ; 1.
DR   PANTHER; PTHR34701:SF1; TRANSCRIPTIONAL REGULATOR MRAZ; 1.
DR   Pfam; PF02381; MraZ; 2.
DR   SUPFAM; SSF89447; AbrB/MazE/MraZ-like; 1.
DR   PROSITE; PS51740; SPOVT_ABRB; 2.
PE   3: Inferred from homology;
KW   Cell cycle {ECO:0000313|EMBL:AWD62056.1};
KW   Cell division {ECO:0000313|EMBL:AWD62056.1};
KW   Cytoplasm {ECO:0000256|ARBA:ARBA00022490, ECO:0000256|HAMAP-Rule:MF_01008};
KW   DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|HAMAP-
KW   Rule:MF_01008}; Repeat {ECO:0000256|ARBA:ARBA00022737};
KW   Transcription {ECO:0000256|ARBA:ARBA00023163, ECO:0000256|HAMAP-
KW   Rule:MF_01008};
KW   Transcription regulation {ECO:0000256|ARBA:ARBA00023015, ECO:0000256|HAMAP-
KW   Rule:MF_01008}.
FT   DOMAIN          5..47
FT                   /note="SpoVT-AbrB"
FT                   /evidence="ECO:0000259|PROSITE:PS51740"
FT   DOMAIN          76..119
FT                   /note="SpoVT-AbrB"
FT                   /evidence="ECO:0000259|PROSITE:PS51740"
SQ   SEQUENCE   142 AA;  16246 MW;  ACBB47AA4E396DC1 CRC64;
     MLMGEFTHTI DSKGRLIIPA KFREQLGAHF IVTRGLDGCL FGYPLNEWAI LEQKLKALPL
     TKRDARAFVR FLYSAATDCE IDKQGRINIP ITLRTHASLE KKCVIVGVSN RLEIWSAERW
     NKFTSETADN FDEIAEDLNI DF
//