ID   Q389X4_TRYB2            Unreviewed;       601 AA.
AC   Q389X4;
DT   22-NOV-2005, integrated into UniProtKB/TrEMBL.
DT   22-NOV-2005, sequence version 1.
DT   03-MAY-2023, entry version 77.
DE   RecName: Full=VPS9 domain-containing protein {ECO:0000259|PROSITE:PS51205};
GN   ORFNames=Tb10.6k15.0260 {ECO:0000313|EMBL:EAN78396.1};
OS   Trypanosoma brucei brucei (strain 927/4 GUTat10.1).
OC   Eukaryota; Discoba; Euglenozoa; Kinetoplastea; Metakinetoplastina;
OC   Trypanosomatida; Trypanosomatidae; Trypanosoma.
OX   NCBI_TaxID=185431 {ECO:0000313|EMBL:EAN78396.1, ECO:0000313|Proteomes:UP000008524};
RN   [1] {ECO:0000313|EMBL:EAN78396.1, ECO:0000313|Proteomes:UP000008524}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=927/4 GUTat10.1 {ECO:0000313|EMBL:EAN78396.1,
RC   ECO:0000313|Proteomes:UP000008524};
RX   PubMed=16020726; DOI=10.1126/science.1112642;
RA   Berriman M., Ghedin E., Hertz-Fowler C., Blandin G., Renauld H.,
RA   Bartholomeu D.C., Lennard N.J., Caler E., Hamlin N.E., Haas B., Bohme U.,
RA   Hannick L., Aslett M.A., Shallom J., Marcello L., Hou L., Wickstead B.,
RA   Alsmark U.C., Arrowsmith C., Atkin R.J., Barron A.J., Bringaud F.,
RA   Brooks K., Carrington M., Cherevach I., Chillingworth T.J., Churcher C.,
RA   Clark L.N., Corton C.H., Cronin A., Davies R.M., Doggett J., Djikeng A.,
RA   Feldblyum T., Field M.C., Fraser A., Goodhead I., Hance Z., Harper D.,
RA   Harris B.R., Hauser H., Hostetler J., Ivens A., Jagels K., Johnson D.,
RA   Johnson J., Jones K., Kerhornou A.X., Koo H., Larke N., Landfear S.,
RA   Larkin C., Leech V., Line A., Lord A., Macleod A., Mooney P.J., Moule S.,
RA   Martin D.M., Morgan G.W., Mungall K., Norbertczak H., Ormond D., Pai G.,
RA   Peacock C.S., Peterson J., Quail M.A., Rabbinowitsch E., Rajandream M.A.,
RA   Reitter C., Salzberg S.L., Sanders M., Schobel S., Sharp S., Simmonds M.,
RA   Simpson A.J., Tallon L., Turner C.M., Tait A., Tivey A.R., Van Aken S.,
RA   Walker D., Wanless D., Wang S., White B., White O., Whitehead S.,
RA   Woodward J., Wortman J., Adams M.D., Embley T.M., Gull K., Ullu E.,
RA   Barry J.D., Fairlamb A.H., Opperdoes F., Barrell B.G., Donelson J.E.,
RA   Hall N., Fraser C.M., Melville S.E., El-Sayed N.M.;
RT   "The genome of the African trypanosome Trypanosoma brucei.";
RL   Science 309:416-422(2005).
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DR   EMBL; CM000208; EAN78396.1; -; Genomic_DNA.
DR   RefSeq; XP_823224.1; XM_818131.1.
DR   AlphaFoldDB; Q389X4; -.
DR   STRING; 5691.EAN78396; -.
DR   PaxDb; Q389X4; -.
DR   GeneID; 3661848; -.
DR   KEGG; tbr:Tb10.6k15.0260; -.
DR   eggNOG; KOG2319; Eukaryota.
DR   InParanoid; Q389X4; -.
DR   OMA; HPCKLHI; -.
DR   OrthoDB; 20678at2759; -.
DR   Proteomes; UP000008524; Chromosome 10.
DR   GO; GO:0020016; C:ciliary pocket; IDA:GeneDB.
DR   GO; GO:0005737; C:cytoplasm; IDA:GeneDB.
DR   GO; GO:0005829; C:cytosol; IBA:GO_Central.
DR   GO; GO:0030139; C:endocytic vesicle; IBA:GO_Central.
DR   GO; GO:0005768; C:endosome; IDA:GeneDB.
DR   GO; GO:0005794; C:Golgi apparatus; IDA:GeneDB.
DR   GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IBA:GO_Central.
DR   GO; GO:0031267; F:small GTPase binding; IBA:GO_Central.
DR   GO; GO:0006897; P:endocytosis; IMP:GeneDB.
DR   GO; GO:0010608; P:post-transcriptional regulation of gene expression; IDA:GeneDB.
DR   Gene3D; 1.10.246.120; -; 1.
DR   Gene3D; 1.20.1050.80; VPS9 domain; 1.
DR   InterPro; IPR003123; VPS9.
DR   InterPro; IPR045046; Vps9-like.
DR   InterPro; IPR037191; VPS9_dom_sf.
DR   PANTHER; PTHR23101:SF25; GTPASE-ACTIVATING PROTEIN AND VPS9 DOMAIN-CONTAINING PROTEIN 1; 1.
DR   PANTHER; PTHR23101; RAB GDP/GTP EXCHANGE FACTOR; 1.
DR   Pfam; PF02204; VPS9; 1.
DR   SMART; SM00167; VPS9; 1.
DR   SUPFAM; SSF109993; VPS9 domain; 1.
DR   PROSITE; PS51205; VPS9; 1.
PE   4: Predicted;
KW   Reference proteome {ECO:0000313|Proteomes:UP000008524}.
FT   DOMAIN          323..479
FT                   /note="VPS9"
FT                   /evidence="ECO:0000259|PROSITE:PS51205"
FT   REGION          187..209
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        189..203
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   601 AA;  66619 MW;  A884516F1D634C5D CRC64;
     MNSAASEEQT NVFLMAIRPG GILYPQLQCA PMEVLCCPRQ SSLVETGFAP YLSLPAPVEN
     SVVTLSINET TFHLTSTQQE KVSQVLREEF LVYHTLRFAS VASSSFVTGR GHKGEFSSDL
     KSIARFGRIG ACAVIGDSIT VQLQQREERT LPDGGVNVFI LEEPFMDASE RQNSIAALKR
     AVGCSDDGSP QNALGSSGGA SPSGPMQGRE WRYTREAIES YRRGVSKETD ERFAEFQQLM
     KKPMCFPIVK TLSGFLEAVD KRDSLQIKSS HVTHAITLCM NQCRQIPLLL DDWEKLRIIE
     EGLEKHIMTK LFKRTFGVCP EEQKCEAELS EKLHRLSKSV RAQDLEALEE VESHNCWEQA
     MYELDAMNFF KSPRGKFLCS LRAYQQLTEI VRDTVAEIKK ARGKNPNKAL DADDFGANEF
     LPCFLLLVLR ACPRNFYLNV QYVKNFHSPD RMTPEESYCL ATLESAVSFW QSYSNASTGT
     VTPACAVPAA PAPVSSAPVP VVEPQLQPQA NFLDSLFTSP ASSIIIPTSG PVDLSSSYNF
     DDFFNGGGGT VLTPPKKENK INVTKLLLDD KKAFDDLSVA ELRAVVEEAR SLLAEKRNAR
     S
//