ID DFB30_RAT Reviewed; 75 AA. AC Q32ZG2; DT 14-OCT-2008, integrated into UniProtKB/Swiss-Prot. DT 06-DEC-2005, sequence version 1. DT 02-OCT-2024, entry version 79. DE RecName: Full=Beta-defensin 30; DE Short=BD-30; DE AltName: Full=Defensin, beta 30; DE Flags: Precursor; GN Name=Defb30; OS Rattus norvegicus (Rat). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; OC Murinae; Rattus. OX NCBI_TaxID=10116; RN [1] RP NUCLEOTIDE SEQUENCE [MRNA]. RX PubMed=16033865; DOI=10.1152/physiolgenomics.00104.2005; RA Patil A.A., Cai Y., Sang Y., Blecha F., Zhang G.; RT "Cross-species analysis of the mammalian beta-defensin gene family: RT presence of syntenic gene clusters and preferential expression in the male RT reproductive tract."; RL Physiol. Genomics 23:5-17(2005). RN [2] RP NUCLEOTIDE SEQUENCE [MRNA]. RC STRAIN=Wistar; TISSUE=Epididymis; RX PubMed=16457734; DOI=10.1186/1477-7827-4-7; RA Yenugu S., Chintalgattu V., Wingard C.J., Radhakrishnan Y., French F.S., RA Hall S.H.; RT "Identification, cloning and functional characterization of novel beta- RT defensins in the rat (Rattus norvegicus)."; RL Reprod. Biol. Endocrinol. 4:7-7(2006). CC -!- FUNCTION: Has antibacterial activity. {ECO:0000250}. CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}. CC -!- SIMILARITY: Belongs to the beta-defensin family. {ECO:0000305}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AY621361; AAT51900.1; -; mRNA. DR EMBL; AY600146; AAU04550.1; -; mRNA. DR RefSeq; NP_001032620.1; NM_001037531.1. DR RefSeq; XP_008768998.1; XM_008770776.1. DR AlphaFoldDB; Q32ZG2; -. DR SMR; Q32ZG2; -. DR STRING; 10116.ENSRNOP00000055981; -. DR PaxDb; 10116-ENSRNOP00000055981; -. DR Ensembl; ENSRNOT00000059211.4; ENSRNOP00000055981.2; ENSRNOG00000038758.4. DR Ensembl; ENSRNOT00055022284; ENSRNOP00055018090; ENSRNOG00055013012. DR Ensembl; ENSRNOT00060031649; ENSRNOP00060025714; ENSRNOG00060018428. DR Ensembl; ENSRNOT00065051869; ENSRNOP00065042694; ENSRNOG00065030040. DR GeneID; 641656; -. DR KEGG; rno:641656; -. DR UCSC; RGD:1559641; rat. DR AGR; RGD:1559641; -. DR CTD; 73670; -. DR RGD; 1559641; Defb30. DR eggNOG; ENOG502TF02; Eukaryota. DR GeneTree; ENSGT00530000064429; -. DR HOGENOM; CLU_181906_3_0_1; -. DR InParanoid; Q32ZG2; -. DR OMA; NTCWRTK; -. DR OrthoDB; 5003090at2759; -. DR PhylomeDB; Q32ZG2; -. DR Reactome; R-RNO-1461957; Beta defensins. DR Reactome; R-RNO-1461973; Defensins. DR PRO; PR:Q32ZG2; -. DR Proteomes; UP000002494; Chromosome 15. DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell. DR GO; GO:0042742; P:defense response to bacterium; IEA:UniProtKB-KW. DR GO; GO:0045087; P:innate immune response; IEA:InterPro. DR InterPro; IPR050544; Beta-defensin. DR InterPro; IPR025933; Beta_defensin_dom. DR PANTHER; PTHR15001; BETA-DEFENSIN 123-RELATED; 1. DR PANTHER; PTHR15001:SF10; BETA-DEFENSIN 135; 1. DR Pfam; PF13841; Defensin_beta_2; 1. PE 3: Inferred from homology; KW Antibiotic; Antimicrobial; Defensin; Disulfide bond; Reference proteome; KW Secreted; Signal. FT SIGNAL 1..22 FT /evidence="ECO:0000255" FT CHAIN 23..75 FT /note="Beta-defensin 30" FT /id="PRO_0000352711" FT DISULFID 35..62 FT /evidence="ECO:0000250" FT DISULFID 42..56 FT /evidence="ECO:0000250" FT DISULFID 46..63 FT /evidence="ECO:0000250" SQ SEQUENCE 75 AA; 8708 MW; 84600A03982EEC1C CRC64; MGSLQLILVL FVLLSDVPPV RSGVNMYIRQ IYDTCWKLKG HCRNVCGKKE IFHIFCGTQF LCCIERKEMP VLFVK //