ID Q32PR9_DANRE Unreviewed; 513 AA. AC Q32PR9; DT 06-DEC-2005, integrated into UniProtKB/TrEMBL. DT 06-DEC-2005, sequence version 1. DT 07-OCT-2020, entry version 98. DE SubName: Full=Zgc:123271 {ECO:0000313|EMBL:AAI08009.1}; GN Name=kcnk5a {ECO:0000313|ZFIN:ZDB-GENE-051113-112}; GN Synonyms=zgc:123271 {ECO:0000313|EMBL:AAI08009.1}; OS Danio rerio (Zebrafish) (Brachydanio rerio). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; OC Danionidae; Danioninae; Danio. OX NCBI_TaxID=7955 {ECO:0000313|EMBL:AAI08009.1}; RN [1] {ECO:0000313|EMBL:AAI08009.1} RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. RC TISSUE=Testis {ECO:0000313|EMBL:AAI08009.1}; RG NIH - Zebrafish Gene Collection (ZGC) project; RL Submitted (OCT-2005) to the EMBL/GenBank/DDBJ databases. CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi- CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}. CC -!- SIMILARITY: Belongs to the two pore domain potassium channel CC (TC 1.A.1.8) family. {ECO:0000256|ARBA:ARBA00006666, CC ECO:0000256|RuleBase:RU003857}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; BC108008; AAI08009.1; -; mRNA. DR RefSeq; NP_001032478.1; NM_001037401.1. DR GeneID; 570159; -. DR KEGG; dre:570159; -. DR CTD; 570159; -. DR ZFIN; ZDB-GENE-051113-112; kcnk5a. DR KO; K04916; -. DR OrthoDB; 1211599at2759; -. DR PhylomeDB; Q32PR9; -. DR GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central. DR GO; GO:0005267; F:potassium channel activity; IDA:ZFIN. DR GO; GO:0022841; F:potassium ion leak channel activity; IBA:GO_Central. DR GO; GO:0071805; P:potassium ion transmembrane transport; IBA:GO_Central. DR GO; GO:0030322; P:stabilization of membrane potential; IBA:GO_Central. DR InterPro; IPR003280; 2pore_dom_K_chnl. DR InterPro; IPR003092; 2pore_dom_K_chnl_TASK. DR InterPro; IPR013099; K_chnl_dom. DR Pfam; PF07885; Ion_trans_2; 2. DR PRINTS; PR01333; 2POREKCHANEL. DR PRINTS; PR01095; TASKCHANNEL. PE 2: Evidence at transcript level; KW Ion channel {ECO:0000256|RuleBase:RU003857}; KW Ion transport {ECO:0000256|RuleBase:RU003857}; KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius}; KW Potassium {ECO:0000256|ARBA:ARBA00022958}; KW Potassium channel {ECO:0000256|ARBA:ARBA00022826}; KW Potassium transport {ECO:0000256|ARBA:ARBA00022538}; KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, KW ECO:0000256|RuleBase:RU003857, ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989, KW ECO:0000256|SAM:Phobius}; KW Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|RuleBase:RU003857}. FT TRANSMEM 7..26 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT TRANSMEM 85..104 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT TRANSMEM 116..138 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT TRANSMEM 158..182 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT TRANSMEM 194..213 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT TRANSMEM 225..244 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT DOMAIN 79..137 FT /note="Ion_trans_2" FT /evidence="ECO:0000259|Pfam:PF07885" FT DOMAIN 165..248 FT /note="Ion_trans_2" FT /evidence="ECO:0000259|Pfam:PF07885" FT REGION 457..513 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 457..483 FT /note="Polyampholyte" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 497..513 FT /note="Polyampholyte" FT /evidence="ECO:0000256|SAM:MobiDB-lite" SQ SEQUENCE 513 AA; 58012 MW; A88E5630AB9FFE0E CRC64; MVDKGPLLTS AIIFYLSIGA AIFQVIEEPN WEIAVRKYRA DKESILKQYP CLTKADLDYI LEVVSDAAGQ GITITGDKTF NNWNWPNAVI FAATVITTIG YGNIAPKTPS GRVFCIFYGL FGVPLCFTWI SELGKFFGGR AKHLGWYLTK KGVTLRKTQL TCTAVFLLWG VLIHLVIPPF VFMTQEGWTY IEGLYFSFVT LTTIGFGDLV AGVDPNAEYP TLYRYFVEVW IYLGLAWLSL FFNWKVRMVV EAHKALKKHR KRRRLSLDEL QLKESHKTLH LPPTPNDVNI FSFLSKKKEG YNDLIKQIGA DKGENQCVST MNSRKNAAAK RSKSCSDALS INGNTIVSLD GSPRLKRHYS FSDRVAVALS KSKGYLFSQE ECLLMTEKLE EGDTDSQCMG MSENQLDKEA GESHKALISE GCRNSQITWD SKGHQTNMFP NANITFIDED NFVNNNREDE NDFMPSFKSD EPDFRKEEDS ESETSVFTGC GSDHGQSYER LVEEYSKEDN TDI //