ID CR021_HUMAN Reviewed; 220 AA. AC Q32NC0; Q6GW03; Q9BXV6; Q9BXW2; DT 06-MAR-2007, integrated into UniProtKB/Swiss-Prot. DT 06-DEC-2005, sequence version 1. DT 23-FEB-2022, entry version 119. DE RecName: Full=UPF0711 protein C18orf21; DE AltName: Full=HBV X-transactivated gene 13 protein; DE AltName: Full=HBV XAg-transactivated protein 13; GN Name=C18orf21; Synonyms=XTP13; ORFNames=PNAS-124, PNAS-131; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; OC Homo. OX NCBI_TaxID=9606; RN [1] RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), AND VARIANT ALA-132. RA Cheng J., Liu Y., Hong Y., Wang J.-J., Yang Q.; RT "Screening and cloning of the target genes transactivated by hepatitis B RT virus X protein by microarray assay."; RL Submitted (MAY-2004) to the EMBL/GenBank/DDBJ databases. RN [2] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2), AND VARIANT RP ALA-132. RC TISSUE=Colon; RX PubMed=15489334; DOI=10.1101/gr.2596504; RG The MGC Project Team; RT "The status, quality, and expansion of the NIH full-length cDNA project: RT the Mammalian Gene Collection (MGC)."; RL Genome Res. 14:2121-2127(2004). RN [3] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 14-220 (ISOFORM 1). RC TISSUE=Promyelocytic leukemia; RA Yu W.-Q., Sun B.-Z., Chai Y.-B., Zhu F., Liu X.-S., Li Z., Lu F., Yan W., RA Yang H., Zhao Z.-L.; RT "Human acute promyelocytic leukemia cell line NB4's RT apoptosis/differentiation related genes."; RL Submitted (JUN-2000) to the EMBL/GenBank/DDBJ databases. RN [4] RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-126; THR-130 AND THR-139, AND RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RC TISSUE=Cervix carcinoma; RX PubMed=18669648; DOI=10.1073/pnas.0805139105; RA Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., RA Elledge S.J., Gygi S.P.; RT "A quantitative atlas of mitotic phosphorylation."; RL Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008). CC -!- ALTERNATIVE PRODUCTS: CC Event=Alternative splicing; Named isoforms=2; CC Name=1; CC IsoId=Q32NC0-1; Sequence=Displayed; CC Name=2; CC IsoId=Q32NC0-2; Sequence=VSP_055184; CC -!- SIMILARITY: Belongs to the UPF0711 family. {ECO:0000305}. CC -!- SEQUENCE CAUTION: CC Sequence=AAK07541.1; Type=Erroneous initiation; Evidence={ECO:0000305}; CC Sequence=AAK07547.1; Type=Frameshift; Evidence={ECO:0000305}; CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AY631401; AAT51696.1; -; mRNA. DR EMBL; BC025950; -; NOT_ANNOTATED_CDS; mRNA. DR EMBL; BC108730; AAI08731.1; -; mRNA. DR EMBL; BC119765; AAI19766.1; -; mRNA. DR EMBL; BC119766; AAI19767.1; -; mRNA. DR EMBL; AF277182; AAK07541.1; ALT_INIT; mRNA. DR EMBL; AF277189; AAK07547.1; ALT_SEQ; mRNA. DR CCDS; CCDS11916.2; -. [Q32NC0-1] DR CCDS; CCDS56064.1; -. [Q32NC0-2] DR RefSeq; NP_001188403.1; NM_001201474.1. [Q32NC0-2] DR RefSeq; NP_001188404.1; NM_001201475.1. [Q32NC0-2] DR RefSeq; NP_113634.3; NM_031446.4. [Q32NC0-1] DR BioGRID; 123699; 150. DR IntAct; Q32NC0; 22. DR STRING; 9606.ENSP00000465517; -. DR iPTMnet; Q32NC0; -. DR PhosphoSitePlus; Q32NC0; -. DR BioMuta; C18orf21; -. DR DMDM; 121942208; -. DR EPD; Q32NC0; -. DR jPOST; Q32NC0; -. DR MassIVE; Q32NC0; -. DR MaxQB; Q32NC0; -. DR PaxDb; Q32NC0; -. DR PeptideAtlas; Q32NC0; -. DR PRIDE; Q32NC0; -. DR ProteomicsDB; 61619; -. [Q32NC0-1] DR Antibodypedia; 54637; 24 antibodies from 11 providers. DR DNASU; 83608; -. DR Ensembl; ENST00000333234; ENSP00000329492; ENSG00000141428. [Q32NC0-2] DR Ensembl; ENST00000592875; ENSP00000465517; ENSG00000141428. DR Ensembl; ENST00000610527; ENSP00000480486; ENSG00000141428. [Q32NC0-2] DR GeneID; 83608; -. DR KEGG; hsa:83608; -. DR MANE-Select; ENST00000592875.6; ENSP00000465517.1; NM_031446.5; NP_113634.3. DR UCSC; uc002kzc.4; human. [Q32NC0-1] DR CTD; 83608; -. DR DisGeNET; 83608; -. DR GeneCards; C18orf21; -. DR HGNC; HGNC:28802; C18orf21. DR HPA; ENSG00000141428; Low tissue specificity. DR neXtProt; NX_Q32NC0; -. DR OpenTargets; ENSG00000141428; -. DR PharmGKB; PA134888949; -. DR VEuPathDB; HostDB:ENSG00000141428; -. DR eggNOG; ENOG502S2A1; Eukaryota. DR GeneTree; ENSGT00390000013383; -. DR HOGENOM; CLU_110760_0_0_1; -. DR InParanoid; Q32NC0; -. DR OMA; HKGVNRD; -. DR OrthoDB; 1377101at2759; -. DR PhylomeDB; Q32NC0; -. DR PathwayCommons; Q32NC0; -. DR SignaLink; Q32NC0; -. DR BioGRID-ORCS; 83608; 297 hits in 995 CRISPR screens. DR GenomeRNAi; 83608; -. DR Pharos; Q32NC0; Tdark. DR PRO; PR:Q32NC0; -. DR Proteomes; UP000005640; Chromosome 18. DR RNAct; Q32NC0; protein. DR Bgee; ENSG00000141428; Expressed in quadriceps femoris and 212 other tissues. DR ExpressionAtlas; Q32NC0; baseline and differential. DR Genevisible; Q32NC0; HS. DR InterPro; IPR029779; DUF4674. DR PANTHER; PTHR31402; PTHR31402; 1. DR Pfam; PF15719; DUF4674; 1. PE 1: Evidence at protein level; KW Alternative splicing; Phosphoprotein; Reference proteome. FT CHAIN 1..220 FT /note="UPF0711 protein C18orf21" FT /id="PRO_0000279448" FT REGION 117..181 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 120..181 FT /note="Polar residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT MOD_RES 126 FT /note="Phosphoserine" FT /evidence="ECO:0007744|PubMed:18669648" FT MOD_RES 130 FT /note="Phosphothreonine" FT /evidence="ECO:0007744|PubMed:18669648" FT MOD_RES 139 FT /note="Phosphothreonine" FT /evidence="ECO:0007744|PubMed:18669648" FT VAR_SEQ 1..88 FT /note="Missing (in isoform 2)" FT /evidence="ECO:0000303|PubMed:15489334, ECO:0000303|Ref.1" FT /id="VSP_055184" FT VARIANT 132 FT /note="T -> A (in dbSNP:rs2276314)" FT /evidence="ECO:0000269|PubMed:15489334, ECO:0000269|Ref.1" FT /id="VAR_030903" FT CONFLICT 212 FT /note="S -> F (in Ref. 2; AAK07541)" FT /evidence="ECO:0000305" SQ SEQUENCE 220 AA; 24827 MW; 3BB72C83F47F14EF CRC64; MRQKHYLEAA ARGLHDSCPG QARYLLWAYT SSHDDKSTFE ETCPYCFQLL VLDNSRVRLK PKARLTPKIQ KLLNREARNY TLSFKEAKMV KKFKDSKSVL LITCKTCNRT VKHHGKSRSF VSTLKSNPAT PTSKLSLKTP ERRTANPNHD MSGSKGKSPA SVFRTPTSGQ SVSTCSSKNT SKTKKHFSQL KMLLSQNESQ KIPKVDFRNF LSSLKGGLLK //