ID XGPT_DESDG Reviewed; 162 AA. AC Q311U1; DT 28-NOV-2006, integrated into UniProtKB/Swiss-Prot. DT 06-DEC-2005, sequence version 1. DT 02-OCT-2007, entry version 22. DE Xanthine phosphoribosyltransferase (EC 2.4.2.22) (Xanthine-guanine DE phosphoribosyltransferase) (XGPRT). GN Name=gpt; OrderedLocusNames=Dde_1506; OS Desulfovibrio desulfuricans (strain G20). OC Bacteria; Proteobacteria; Deltaproteobacteria; Desulfovibrionales; OC Desulfovibrionaceae; Desulfovibrio. OX NCBI_TaxID=207559; RN [1] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RA Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina T., RA Hammon N., Israni S., Pitluck S., Goodwin L.A., Schmutz J., RA Larimer F., Land M., Kyrpides N., Ivanova N., Richardson P.; RT "Complete sequence of Desulfovibrio desulfuricans G20."; RL Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases. CC -!- FUNCTION: Acts on guanine, xanthine and to a lesser extent CC hypoxanthine (By similarity). CC -!- CATALYTIC ACTIVITY: XMP + diphosphate = 5-phospho-alpha-D-ribose CC 1-diphosphate + xanthine. CC -!- COFACTOR: Binds 1 magnesium ion per subunit (By similarity). CC -!- COFACTOR: Binds 1 sulfate ion per subunit (By similarity). CC -!- PATHWAY: Purine salvage. CC -!- SUBUNIT: Homotrimer (By similarity). CC -!- SUBCELLULAR LOCATION: Cytoplasm (By similarity). CC -!- SIMILARITY: Belongs to the purine/pyrimidine CC phosphoribosyltransferase family. XGPT subfamily. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; CP000112; ABB38305.1; -; Genomic_DNA. DR RefSeq; YP_388000.1; -. DR GeneID; 3756059; -. DR GenomeReviews; CP000112_GR; Dde_1506. DR KEGG; dde:Dde_1506; -. DR BioCyc; DDES207559:DDE_1506-MONOMER; -. DR GO; GO:0000287; F:magnesium ion binding; IEA:HAMAP. DR GO; GO:0000310; F:xanthine phosphoribosyltransferase activity; IEA:HAMAP. DR GO; GO:0006166; P:purine ribonucleoside salvage; IEA:HAMAP. DR HAMAP; MF_01903; -; 1. DR InterPro; IPR002375; Pr/py_rp_transf. DR InterPro; IPR000836; PRtransferase. DR Pfam; PF00156; Pribosyltran; 1. DR PROSITE; PS00103; PUR_PYR_PR_TRANSFER; 1. PE 3: Inferred from homology; KW Complete proteome; Cytoplasm; Glycosyltransferase; Magnesium; KW Metal-binding; Purine salvage; Transferase. FT CHAIN 1 162 Xanthine phosphoribosyltransferase. FT /FTId=PRO_0000261005. FT METAL 95 95 Magnesium (By similarity). FT BINDING 43 43 Sulfate (By similarity). SQ SEQUENCE 162 AA; 18276 MW; 43E478F3FDAE31EC CRC64; MADPDRYNKM FPVSWEQLHR DTRALSWRLM ERGPFKGIVA ITRGGLVPAA ILARELEVRL VDTICIASYD WKSQGGISVL KGVEGDGEGW LIVDDLVDTG TTARAVREML PKAHFATVYA KPSGRPVVDT YITEVSQDTW ILFPWDSEIQ YVQPLVNRRQ EG //