ID Q304Z4_HUMAN Unreviewed; 665 AA. AC Q304Z4; DT 06-DEC-2005, integrated into UniProtKB/TrEMBL. DT 06-DEC-2005, sequence version 1. DT 02-OCT-2024, entry version 65. DE SubName: Full=Envelope polyprotein {ECO:0000313|EMBL:ABB52637.1}; GN Name=env {ECO:0000313|EMBL:ABB52637.1}; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; OC Homo. OX NCBI_TaxID=9606 {ECO:0000313|EMBL:ABB52637.1}; RN [1] {ECO:0000313|Ensembl:ENSP00000519514.1, ECO:0000313|Proteomes:UP000005640} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=11237011; DOI=10.1038/35057062; RG International Human Genome Sequencing Consortium; RA Lander E.S., Linton L.M., Birren B., Nusbaum C., Zody M.C., Baldwin J., RA Devon K., Dewar K., Doyle M., FitzHugh W., Funke R., Gage D., Harris K., RA Heaford A., Howland J., Kann L., Lehoczky J., LeVine R., McEwan P., RA McKernan K., Meldrim J., Mesirov J.P., Miranda C., Morris W., Naylor J., RA Raymond C., Rosetti M., Santos R., Sheridan A., Sougnez C., RA Stange-Thomann N., Stojanovic N., Subramanian A., Wyman D., Rogers J., RA Sulston J., Ainscough R., Beck S., Bentley D., Burton J., Clee C., RA Carter N., Coulson A., Deadman R., Deloukas P., Dunham A., Dunham I., RA Durbin R., French L., Grafham D., Gregory S., Hubbard T., Humphray S., RA Hunt A., Jones M., Lloyd C., McMurray A., Matthews L., Mercer S., Milne S., RA Mullikin J.C., Mungall A., Plumb R., Ross M., Shownkeen R., Sims S., RA Waterston R.H., Wilson R.K., Hillier L.W., McPherson J.D., Marra M.A., RA Mardis E.R., Fulton L.A., Chinwalla A.T., Pepin K.H., Gish W.R., RA Chissoe S.L., Wendl M.C., Delehaunty K.D., Miner T.L., Delehaunty A., RA Kramer J.B., Cook L.L., Fulton R.S., Johnson D.L., Minx P.J., Clifton S.W., RA Hawkins T., Branscomb E., Predki P., Richardson P., Wenning S., Slezak T., RA Doggett N., Cheng J.F., Olsen A., Lucas S., Elkin C., Uberbacher E., RA Frazier M., Gibbs R.A., Muzny D.M., Scherer S.E., Bouck J.B., RA Sodergren E.J., Worley K.C., Rives C.M., Gorrell J.H., Metzker M.L., RA Naylor S.L., Kucherlapati R.S., Nelson D.L., Weinstock G.M., Sakaki Y., RA Fujiyama A., Hattori M., Yada T., Toyoda A., Itoh T., Kawagoe C., RA Watanabe H., Totoki Y., Taylor T., Weissenbach J., Heilig R., Saurin W., RA Artiguenave F., Brottier P., Bruls T., Pelletier E., Robert C., Wincker P., RA Smith D.R., Doucette-Stamm L., Rubenfield M., Weinstock K., Lee H.M., RA Dubois J., Rosenthal A., Platzer M., Nyakatura G., Taudien S., Rump A., RA Yang H., Yu J., Wang J., Huang G., Gu J., Hood L., Rowen L., Madan A., RA Qin S., Davis R.W., Federspiel N.A., Abola A.P., Proctor M.J., Myers R.M., RA Schmutz J., Dickson M., Grimwood J., Cox D.R., Olson M.V., Kaul R., RA Raymond C., Shimizu N., Kawasaki K., Minoshima S., Evans G.A., RA Athanasiou M., Schultz R., Roe B.A., Chen F., Pan H., Ramser J., RA Lehrach H., Reinhardt R., McCombie W.R., de la Bastide M., Dedhia N., RA Blocker H., Hornischer K., Nordsiek G., Agarwala R., Aravind L., RA Bailey J.A., Bateman A., Batzoglou S., Birney E., Bork P., Brown D.G., RA Burge C.B., Cerutti L., Chen H.C., Church D., Clamp M., Copley R.R., RA Doerks T., Eddy S.R., Eichler E.E., Furey T.S., Galagan J., Gilbert J.G., RA Harmon C., Hayashizaki Y., Haussler D., Hermjakob H., Hokamp K., Jang W., RA Johnson L.S., Jones T.A., Kasif S., Kaspryzk A., Kennedy S., Kent W.J., RA Kitts P., Koonin E.V., Korf I., Kulp D., Lancet D., Lowe T.M., RA McLysaght A., Mikkelsen T., Moran J.V., Mulder N., Pollara V.J., RA Ponting C.P., Schuler G., Schultz J., Slater G., Smit A.F., Stupka E., RA Szustakowski J., Thierry-Mieg D., Thierry-Mieg J., Wagner L., Wallis J., RA Wheeler R., Williams A., Wolf Y.I., Wolfe K.H., Yang S.P., Yeh R.F., RA Collins F., Guyer M.S., Peterson J., Felsenfeld A., Wetterstrand K.A., RA Patrinos A., Morgan M.J., de Jong P., Catanese J.J., Osoegawa K., RA Shizuya H., Choi S., Chen Y.J.; RT "Initial sequencing and analysis of the human genome."; RL Nature 409:860-921(2001). RN [2] {ECO:0000313|Ensembl:ENSP00000519514.1, ECO:0000313|Proteomes:UP000005640} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=12508121; DOI=10.1038/nature01348; RA Heilig R., Eckenberg R., Petit J.L., Fonknechten N., Da Silva C., RA Cattolico L., Levy M., Barbe V., de Berardinis V., Ureta-Vidal A., RA Pelletier E., Vico V., Anthouard V., Rowen L., Madan A., Qin S., Sun H., RA Du H., Pepin K., Artiguenave F., Robert C., Cruaud C., Bruls T., RA Jaillon O., Friedlander L., Samson G., Brottier P., Cure S., Segurens B., RA Aniere F., Samain S., Crespeau H., Abbasi N., Aiach N., Boscus D., RA Dickhoff R., Dors M., Dubois I., Friedman C., Gouyvenoux M., James R., RA Madan A., Mairey-Estrada B., Mangenot S., Martins N., Menard M., Oztas S., RA Ratcliffe A., Shaffer T., Trask B., Vacherie B., Bellemere C., Belser C., RA Besnard-Gonnet M., Bartol-Mavel D., Boutard M., Briez-Silla S., RA Combette S., Dufosse-Laurent V., Ferron C., Lechaplais C., Louesse C., RA Muselet D., Magdelenat G., Pateau E., Petit E., Sirvain-Trukniewicz P., RA Trybou A., Vega-Czarny N., Bataille E., Bluet E., Bordelais I., Dubois M., RA Dumont C., Guerin T., Haffray S., Hammadi R., Muanga J., Pellouin V., RA Robert D., Wunderle E., Gauguet G., Roy A., Sainte-Marthe L., Verdier J., RA Verdier-Discala C., Hillier L., Fulton L., McPherson J., Matsuda F., RA Wilson R., Scarpelli C., Gyapay G., Wincker P., Saurin W., Quetier F., RA Waterston R., Hood L., Weissenbach J.; RT "The DNA sequence and analysis of human chromosome 14."; RL Nature 421:601-607(2003). RN [3] {ECO:0000313|Ensembl:ENSP00000519514.1, ECO:0000313|Proteomes:UP000005640} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=15496913; DOI=10.1038/nature03001; RG International Human Genome Sequencing Consortium; RT "Finishing the euchromatic sequence of the human genome."; RL Nature 431:931-945(2004). RN [4] {ECO:0000313|EMBL:ABB52637.1} RP NUCLEOTIDE SEQUENCE. RX PubMed=15476554; RA Villesen P., Aagaard L., Wiuf C., Pedersen F.S.; RT "Identification of endogenous retroviral reading frames in the human RT genome."; RL Retrovirology 1:32-32(2004). RN [5] {ECO:0000313|EMBL:ABB52637.1} RP NUCLEOTIDE SEQUENCE. RX PubMed=16263238; DOI=10.1016/j.ygeno.2005.08.011; RA Aagaard L., Villesen P., Kjeldbjerg A.L., Pedersen F.S.; RT "The approximately 30-million-year-old ERVPb1 envelope gene is RT evolutionarily conserved among hominoids and Old World monkeys."; RL Genomics 86:685-691(2005). RN [6] {ECO:0000313|Ensembl:ENSP00000519514.1} RP IDENTIFICATION. RG Ensembl; RL Submitted (JUN-2024) to UniProtKB. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AL159141; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; DQ247958; ABB52637.1; -; Genomic_DNA. DR AlphaFoldDB; Q304Z4; -. DR SMR; Q304Z4; -. DR Ensembl; ENST00000714233.1; ENSP00000519514.1; ENSG00000293569.1. DR Proteomes; UP000005640; Chromosome 14. DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW. DR CDD; cd09951; HERV-Rb-like_HR1-HR2; 1. DR Gene3D; 1.10.287.210; -; 1. DR Gene3D; 3.90.310.10; ENV polyprotein, receptor-binding domain; 1. DR InterPro; IPR008981; FMuLV_rcpt-bd. DR InterPro; IPR018154; TLV/ENV_coat_polyprotein. DR PANTHER; PTHR10424:SF83; ENDOGENOUS RETROVIRUS GROUP 3 MEMBER 1 ENV POLYPROTEIN; 1. DR PANTHER; PTHR10424; VIRAL ENVELOPE PROTEIN; 1. DR Pfam; PF00429; TLV_coat; 1. DR SUPFAM; SSF49830; ENV polyprotein, receptor-binding domain; 1. DR SUPFAM; SSF58069; Virus ectodomain; 1. PE 4: Predicted; KW ERV {ECO:0000256|ARBA:ARBA00022783}; Membrane {ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000005640}; KW Transmembrane {ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAM:Phobius}; KW Transposable element {ECO:0000256|ARBA:ARBA00022464}; KW Viral envelope protein {ECO:0000313|EMBL:ABB52637.1}; KW Virion {ECO:0000313|EMBL:ABB52637.1}. FT TRANSMEM 34..56 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT TRANSMEM 600..622 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT REGION 1..24 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 1..22 FT /note="Polar residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" SQ SEQUENCE 665 AA; 73932 MW; CB0F543776B0E615 CRC64; MDPSHPSQES TAPSSVMGHS PRGKSYQTKA KESLILFHLF CYSFFFPCAL ASHLIINVTR SDSPQTITFD ACLVIPCGDL QSQRQLAAAE KYLCPSEADA STLFSFPFCH TWEYVVWTTQ RQDWVPSQDF PLAVLKPYIH FTKGIAPPNC RYNQCNPVQI SITIPTLQDS SPTLNRFYGM GADVRGKDPI GFFELHLSTS PSLISPRLSS STPANQTIVS SSNDKSKVAI VEVKNLKQTL TIETGYKETN AWMEWIEYSV RSLNKSDCYA CAQGRPEAQV VPFPLGWSSD QPGMGCMVAL FQHPTAWDSE FCRTLSVLFP ETQHLEGEPP RAIQPPSPDA KFTSCLSRQG KNLEFLGDLK GCSELKSFQE LTNQSALVHA RADVWWYCGG HLLDTLPSNW SGTCALIQLA IPFTLAFQQP EKKKPQRRKT REAPQGSFDS HVYVDEIGVP QGVPDRFKAR DPVAAGFESL FPMVAINKNV AWINYIYYNQ QRFINYTRDA IQGIAEQLGP TSQMAWENRM ALDMILAEKG GVCVMIGTQC CTYIPNNTAP DGTITKALQG LTSLSDELAT NSGITDPFTG WLGQWFGKWK GLMASIVTSL AIAIAVLILV GCCIMPCIRG LVQRLIETAS NKTFPSSSQS YSNKFFPVNE HEIRIILDRF KAEHV //