ID Q304Z4_HUMAN Unreviewed; 665 AA. AC Q304Z4; DT 06-DEC-2005, integrated into UniProtKB/TrEMBL. DT 06-DEC-2005, sequence version 1. DT 27-MAR-2024, entry version 64. DE SubName: Full=Envelope polyprotein {ECO:0000313|EMBL:ABB52637.1}; GN Name=env {ECO:0000313|EMBL:ABB52637.1}; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; OC Homo. OX NCBI_TaxID=9606 {ECO:0000313|EMBL:ABB52637.1}; RN [1] {ECO:0000313|EMBL:ABB52637.1} RP NUCLEOTIDE SEQUENCE. RX PubMed=15476554; RA Villesen P., Aagaard L., Wiuf C., Pedersen F.S.; RT "Identification of endogenous retroviral reading frames in the human RT genome."; RL Retrovirology 1:32-32(2004). RN [2] {ECO:0000313|EMBL:ABB52637.1} RP NUCLEOTIDE SEQUENCE. RX PubMed=16263238; DOI=10.1016/j.ygeno.2005.08.011; RA Aagaard L., Villesen P., Kjeldbjerg A.L., Pedersen F.S.; RT "The approximately 30-million-year-old ERVPb1 envelope gene is RT evolutionarily conserved among hominoids and Old World monkeys."; RL Genomics 86:685-691(2005). CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; DQ247958; ABB52637.1; -; Genomic_DNA. DR AlphaFoldDB; Q304Z4; -. DR SMR; Q304Z4; -. DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW. DR CDD; cd09951; HERV-Rb-like_HR1-HR2; 1. DR Gene3D; 1.10.287.210; -; 1. DR Gene3D; 3.90.310.10; ENV polyprotein, receptor-binding domain; 1. DR InterPro; IPR008981; FMuLV_rcpt-bd. DR InterPro; IPR018154; TLV/ENV_coat_polyprotein. DR PANTHER; PTHR10424:SF83; ENDOGENOUS RETROVIRUS GROUP 3 MEMBER 1 ENV POLYPROTEIN; 1. DR PANTHER; PTHR10424; VIRAL ENVELOPE PROTEIN; 1. DR Pfam; PF00429; TLV_coat; 1. DR SUPFAM; SSF49830; ENV polyprotein, receptor-binding domain; 1. DR SUPFAM; SSF58069; Virus ectodomain; 1. PE 4: Predicted; KW ERV {ECO:0000256|ARBA:ARBA00022783}; Membrane {ECO:0000256|SAM:Phobius}; KW Transmembrane {ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAM:Phobius}; KW Transposable element {ECO:0000256|ARBA:ARBA00022464}; KW Viral envelope protein {ECO:0000313|EMBL:ABB52637.1}; KW Virion {ECO:0000313|EMBL:ABB52637.1}. FT TRANSMEM 34..56 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT TRANSMEM 600..622 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT REGION 1..24 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 1..22 FT /note="Polar residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" SQ SEQUENCE 665 AA; 73932 MW; CB0F543776B0E615 CRC64; MDPSHPSQES TAPSSVMGHS PRGKSYQTKA KESLILFHLF CYSFFFPCAL ASHLIINVTR SDSPQTITFD ACLVIPCGDL QSQRQLAAAE KYLCPSEADA STLFSFPFCH TWEYVVWTTQ RQDWVPSQDF PLAVLKPYIH FTKGIAPPNC RYNQCNPVQI SITIPTLQDS SPTLNRFYGM GADVRGKDPI GFFELHLSTS PSLISPRLSS STPANQTIVS SSNDKSKVAI VEVKNLKQTL TIETGYKETN AWMEWIEYSV RSLNKSDCYA CAQGRPEAQV VPFPLGWSSD QPGMGCMVAL FQHPTAWDSE FCRTLSVLFP ETQHLEGEPP RAIQPPSPDA KFTSCLSRQG KNLEFLGDLK GCSELKSFQE LTNQSALVHA RADVWWYCGG HLLDTLPSNW SGTCALIQLA IPFTLAFQQP EKKKPQRRKT REAPQGSFDS HVYVDEIGVP QGVPDRFKAR DPVAAGFESL FPMVAINKNV AWINYIYYNQ QRFINYTRDA IQGIAEQLGP TSQMAWENRM ALDMILAEKG GVCVMIGTQC CTYIPNNTAP DGTITKALQG LTSLSDELAT NSGITDPFTG WLGQWFGKWK GLMASIVTSL AIAIAVLILV GCCIMPCIRG LVQRLIETAS NKTFPSSSQS YSNKFFPVNE HEIRIILDRF KAEHV //