ID   NIKE_BRUA2              Reviewed;         266 AA.
AC   Q2YL69;
DT   28-NOV-2006, integrated into UniProtKB/Swiss-Prot.
DT   07-FEB-2006, sequence version 1.
DT   16-JUN-2009, entry version 30.
DE   RecName: Full=Nickel import ATP-binding protein nikE;
DE            EC=3.6.3.24;
GN   Name=nikE; OrderedLocusNames=BAB2_0438;
OS   Brucella abortus (strain 2308).
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Rhizobiales;
OC   Brucellaceae; Brucella.
OX   NCBI_TaxID=359391;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16299333; DOI=10.1128/IAI.73.12.8353-8361.2005;
RA   Chain P.S., Comerci D.J., Tolmasky M.E., Larimer F.W., Malfatti S.A.,
RA   Vergez L.M., Aguero F., Land M.L., Ugalde R.A., Garcia E.;
RT   "Whole-genome analyses of speciation events in pathogenic Brucellae.";
RL   Infect. Immun. 73:8353-8361(2005).
CC   -!- FUNCTION: Part of the ABC transporter complex nikABCDE involved in
CC       nickel import. Responsible for energy coupling to the transport
CC       system (By similarity).
CC   -!- CATALYTIC ACTIVITY: ATP + H(2)O + Ni(2+)(Out) = ADP + phosphate +
CC       Ni(2+)(In).
CC   -!- SUBUNIT: The complex is composed of two ATP-binding proteins (nikD
CC       and nikE), two transmembrane proteins (nikB and nikC) and a
CC       solute-binding protein (nikA) (Probable).
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane; Peripheral membrane
CC       protein (By similarity).
CC   -!- SIMILARITY: Belongs to the ABC transporter family. Nickel importer
CC       (TC 3.A.1.5.3) subfamily.
CC   -!- SIMILARITY: Contains 1 ABC transporter domain.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AM040265; CAJ12604.1; -; Genomic_DNA.
DR   RefSeq; YP_418633.1; -.
DR   GeneID; 3827147; -.
DR   GenomeReviews; AM040265_GR; BAB2_0438.
DR   KEGG; bmf:BAB2_0438; -.
DR   HOGENOM; Q2YL69; -.
DR   OMA; Q2YL69; THREERI.
DR   BioCyc; BMEL359391:BAB2_0438-MON; -.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0016151; F:nickel ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0015413; F:nickel-transporting ATPase activity; IEA:HAMAP.
DR   GO; GO:0015675; P:nickel ion transport; IEA:HAMAP.
DR   HAMAP; MF_01712; -; 1.
DR   InterPro; IPR003439; ABC_transporter-like.
DR   InterPro; IPR017871; ABC_transporter_CS.
DR   InterPro; IPR015858; ABC_transpr_NikE.
DR   InterPro; IPR003593; ATPase_AAA+_core.
DR   InterPro; IPR014137; Nickel_nikE.
DR   Pfam; PF00005; ABC_tran; 1.
DR   ProDom; PD000006; ABC_transporter; 1.
DR   SMART; SM00382; AAA; 1.
DR   TIGRFAMs; TIGR02769; nickel_nikE; 1.
DR   PROSITE; PS00211; ABC_TRANSPORTER_1; 1.
DR   PROSITE; PS50893; ABC_TRANSPORTER_2; 1.
DR   PROSITE; PS51248; NIKE; 1.
PE   3: Inferred from homology;
KW   ATP-binding; Cell inner membrane; Cell membrane; Complete proteome;
KW   Hydrolase; Membrane; Nickel; Nickel transport; Nucleotide-binding;
KW   Transport.
FT   CHAIN         1    266       Nickel import ATP-binding protein nikE.
FT                                /FTId=PRO_0000260204.
FT   DOMAIN        4    252       ABC transporter.
FT   NP_BIND      45     52       ATP (Potential).
SQ   SEQUENCE   266 AA;  29180 MW;  CBC0D12AA2731DFB CRC64;
     MSLISADNIV KIYQSHSLVG ASARKTMLHD ISISIGQGET VALLGRSGCG KSTLARLLVG
     LERPTSGEVR FRGVPLTKLD RSGMKAFRRE VQLIFQDSPG AVNARSSVRA IIGEPLRHLT
     SLDETRREER IQELLRLVEL PPEIADRLPA QVSGGQLQRI CIARALAVNP KLIILDEAVS
     NLDIHLQASA LALLTKLQQE GGIAYLFVTH DLRLVQKFAA RCLVMDEGQI VEEIKTADLD
     SMRHPASRLL REAVLPPLPV RAVETN
//