ID Q2VT45_DANRE Unreviewed; 152 AA. AC Q2VT45; DT 10-JAN-2006, integrated into UniProtKB/TrEMBL. DT 10-JAN-2006, sequence version 1. DT 12-APR-2017, entry version 93. DE SubName: Full=Relaxin 3a {ECO:0000313|EMBL:AAX39710.1, ECO:0000313|Ensembl:ENSDARP00000082236}; DE SubName: Full=Relaxin family locus C type 2 {ECO:0000313|EMBL:ACA13585.1}; GN Name=rln3a {ECO:0000313|Ensembl:ENSDARP00000082236, GN ECO:0000313|ZFIN:ZDB-GENE-050310-3}; GN Synonyms=RFLC2 {ECO:0000313|EMBL:ACA13585.1}, rln3 GN {ECO:0000313|ZFIN:ZDB-GENE-050310-3}; OS Danio rerio (Zebrafish) (Brachydanio rerio). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; OC Cyprinidae; Danio. OX NCBI_TaxID=7955; RN [1] {ECO:0000313|EMBL:AAX39710.1} RP NUCLEOTIDE SEQUENCE. RA Park J.I., Hsu S.Y.T.; RT "Characterization and identification of relaxin family in the RT zebrafish."; RL Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|EMBL:ACA13585.1} RP NUCLEOTIDE SEQUENCE. RX PubMed=18463305; DOI=10.1101/gr.7119108; RA Park J.I., Semyonov J., Chang C.L., Yi W., Warren W., Hsu S.Y.; RT "Origin of INSL3-mediated testicular descent in therian mammals."; RL Genome Res. 18:974-985(2008). RN [3] {ECO:0000313|EMBL:ACA13585.1} RP NUCLEOTIDE SEQUENCE. RA Park J., Semyonov J., Chang C.L., Yi W., Warren W., Hsu S.Y.T.; RL Submitted (JAN-2008) to the EMBL/GenBank/DDBJ databases. RN [4] {ECO:0000313|Ensembl:ENSDARP00000082236} RP IDENTIFICATION. RC STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000082236}; RG Ensembl; RL Submitted (FEB-2012) to UniProtKB. RN [5] {ECO:0000313|Ensembl:ENSDARP00000082236, ECO:0000313|Proteomes:UP000000437} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000082236, RC ECO:0000313|Proteomes:UP000000437}; RX PubMed=23594743; DOI=10.1038/nature12111; RA Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., RA Muffato M., Collins J.E., Humphray S., McLaren K., Matthews L., RA McLaren S., Sealy I., Caccamo M., Churcher C., Scott C., Barrett J.C., RA Koch R., Rauch G.J., White S., Chow W., Kilian B., Quintais L.T., RA Guerra-Assuncao J.A., Zhou Y., Gu Y., Yen J., Vogel J.H., Eyre T., RA Redmond S., Banerjee R., Chi J., Fu B., Langley E., Maguire S.F., RA Laird G.K., Lloyd D., Kenyon E., Donaldson S., Sehra H., RA Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M., RA Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J., RA Clee C., Oliver K., Clark R., Riddle C., Elliot D., Threadgold G., RA Harden G., Ware D., Begum S., Mortimore B., Kerry G., Heath P., RA Phillimore B., Tracey A., Corby N., Dunn M., Johnson C., Wood J., RA Clark S., Pelan S., Griffiths G., Smith M., Glithero R., Howden P., RA Barker N., Lloyd C., Stevens C., Harley J., Holt K., Panagiotidis G., RA Lovell J., Beasley H., Henderson C., Gordon D., Auger K., Wright D., RA Collins J., Raisen C., Dyer L., Leung K., Robertson L., Ambridge K., RA Leongamornlert D., McGuire S., Gilderthorp R., Griffiths C., RA Manthravadi D., Nichol S., Barker G., Whitehead S., Kay M., Brown J., RA Murnane C., Gray E., Humphries M., Sycamore N., Barker D., RA Saunders D., Wallis J., Babbage A., Hammond S., RA Mashreghi-Mohammadi M., Barr L., Martin S., Wray P., Ellington A., RA Matthews N., Ellwood M., Woodmansey R., Clark G., Cooper J., RA Tromans A., Grafham D., Skuce C., Pandian R., Andrews R., Harrison E., RA Kimberley A., Garnett J., Fosker N., Hall R., Garner P., Kelly D., RA Bird C., Palmer S., Gehring I., Berger A., Dooley C.M., Ersan-Urun Z., RA Eser C., Geiger H., Geisler M., Karotki L., Kirn A., Konantz J., RA Konantz M., Oberlander M., Rudolph-Geiger S., Teucke M., Lanz C., RA Raddatz G., Osoegawa K., Zhu B., Rapp A., Widaa S., Langford C., RA Yang F., Schuster S.C., Carter N.P., Harrow J., Ning Z., Herrero J., RA Searle S.M., Enright A., Geisler R., Plasterk R.H., Lee C., RA Westerfield M., de Jong P.J., Zon L.I., Postlethwait J.H., RA Nusslein-Volhard C., Hubbard T.J., Roest Crollius H., Rogers J., RA Stemple D.L.; RT "The zebrafish reference genome sequence and its relationship to the RT human genome."; RL Nature 496:498-503(2013). CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|RuleBase:RU000406, CC ECO:0000256|SAAS:SAAS00037338}. CC -!- SIMILARITY: Belongs to the insulin family. CC {ECO:0000256|RuleBase:RU000406, ECO:0000256|SAAS:SAAS00542063}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; BX546473; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AY834223; AAX39710.1; -; mRNA. DR EMBL; EU437454; ACA13585.1; -; mRNA. DR RefSeq; NP_001032892.1; NM_001037803.1. DR UniGene; Dr.52755; -. DR ProteinModelPortal; Q2VT45; -. DR STRING; 7955.ENSDARP00000082236; -. DR Ensembl; ENSDART00000087803; ENSDARP00000082236; ENSDARG00000070780. DR GeneID; 503864; -. DR KEGG; dre:503864; -. DR CTD; 503864; -. DR ZFIN; ZDB-GENE-050310-3; rln3a. DR eggNOG; ENOG410IZRS; Eukaryota. DR eggNOG; ENOG41121Z2; LUCA. DR GeneTree; ENSGT00510000048203; -. DR HOGENOM; HOG000111888; -. DR HOVERGEN; HBG045048; -. DR KO; K05255; -. DR OMA; FMVENFL; -. DR OrthoDB; EOG091G0T4N; -. DR TreeFam; TF333404; -. DR Proteomes; UP000000437; Chromosome 3. DR Bgee; ENSDARG00000070780; -. DR GO; GO:0005576; C:extracellular region; IBA:GO_Central. DR GO; GO:0001664; F:G-protein coupled receptor binding; IBA:GO_Central. DR GO; GO:0005179; F:hormone activity; IBA:GO_Central. DR Gene3D; 1.10.100.10; -; 1. DR InterPro; IPR016179; Insulin-like. DR InterPro; IPR022353; Insulin_CS. DR InterPro; IPR022352; Insulin_family. DR Pfam; PF00049; Insulin; 1. DR PRINTS; PR00276; INSULINFAMLY. DR SMART; SM00078; IlGF; 1. DR SUPFAM; SSF56994; SSF56994; 2. DR PROSITE; PS00262; INSULIN; 1. PE 1: Evidence at protein level; KW Complete proteome {ECO:0000313|Proteomes:UP000000437}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00018004}; KW Proteomics identification {ECO:0000213|PeptideAtlas:Q2VT45}; KW Reference proteome {ECO:0000313|Proteomes:UP000000437}; KW Secreted {ECO:0000256|RuleBase:RU000406, KW ECO:0000256|SAAS:SAAS00037326}; Signal {ECO:0000256|SAM:SignalP}. FT SIGNAL 1 19 {ECO:0000256|SAM:SignalP}. FT CHAIN 20 152 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5009710826. FT DOMAIN 28 152 IlGF. {ECO:0000259|SMART:SM00078}. SQ SEQUENCE 152 AA; 16155 MW; FD17964AE9F5E73E CRC64; MMWKTSALVV CLLLAGVKAL DAGPSYGVKL CGREFIRAVI FTCGGSRWKR SLTNTDEILD LFNSYDSNAA DGSVLFGSAS SSSQHATDSN LPPLGQGEQD GSVFSRPARS LISEEVLEAL RSVDRKGRDV VVGLSNACCK WGCSKGEISS LC //