ID Q2VT45_DANRE Unreviewed; 152 AA. AC Q2VT45; DT 10-JAN-2006, integrated into UniProtKB/TrEMBL. DT 10-JAN-2006, sequence version 1. DT 07-APR-2021, entry version 118. DE SubName: Full=Relaxin 3a {ECO:0000313|EMBL:AAX39710.1, ECO:0000313|Ensembl:ENSDARP00000082236}; DE SubName: Full=Relaxin family locus C type 2 {ECO:0000313|EMBL:ACA13585.1}; GN Name=rln3a {ECO:0000313|Ensembl:ENSDARP00000082236, GN ECO:0000313|ZFIN:ZDB-GENE-050310-3}; GN Synonyms=RFLC2 {ECO:0000313|EMBL:ACA13585.1}, rln3 GN {ECO:0000313|ZFIN:ZDB-GENE-050310-3}; OS Danio rerio (Zebrafish) (Brachydanio rerio). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; OC Danionidae; Danioninae; Danio. OX NCBI_TaxID=7955 {ECO:0000313|EMBL:AAX39710.1}; RN [1] {ECO:0000313|EMBL:AAX39710.1} RP NUCLEOTIDE SEQUENCE. RA Park J.I., Hsu S.Y.T.; RT "Characterization and identification of relaxin family in the zebrafish."; RL Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|EMBL:ACA13585.1} RP NUCLEOTIDE SEQUENCE. RX PubMed=18463305; DOI=10.1101/gr.7119108; RA Park J.I., Semyonov J., Chang C.L., Yi W., Warren W., Hsu S.Y.; RT "Origin of INSL3-mediated testicular descent in therian mammals."; RL Genome Res. 18:974-985(2008). RN [3] {ECO:0000313|EMBL:ACA13585.1} RP NUCLEOTIDE SEQUENCE. RA Park J., Semyonov J., Chang C.L., Yi W., Warren W., Hsu S.Y.T.; RL Submitted (JAN-2008) to the EMBL/GenBank/DDBJ databases. RN [4] {ECO:0000313|Ensembl:ENSDARP00000082236} RP IDENTIFICATION. RC STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000082236}; RG Ensembl; RL Submitted (FEB-2012) to UniProtKB. RN [5] {ECO:0000313|Ensembl:ENSDARP00000082236, ECO:0000313|Proteomes:UP000000437} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000082236, RC ECO:0000313|Proteomes:UP000000437}; RX PubMed=23594743; DOI=10.1038/nature12111; RA Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M., RA Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I., RA Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J., RA White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y., RA Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B., RA Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S., RA Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M., RA Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J., RA Clee C., Oliver K., Clark R., Riddle C., Elliot D., Threadgold G., RA Harden G., Ware D., Begum S., Mortimore B., Kerry G., Heath P., RA Phillimore B., Tracey A., Corby N., Dunn M., Johnson C., Wood J., Clark S., RA Pelan S., Griffiths G., Smith M., Glithero R., Howden P., Barker N., RA Lloyd C., Stevens C., Harley J., Holt K., Panagiotidis G., Lovell J., RA Beasley H., Henderson C., Gordon D., Auger K., Wright D., Collins J., RA Raisen C., Dyer L., Leung K., Robertson L., Ambridge K., Leongamornlert D., RA McGuire S., Gilderthorp R., Griffiths C., Manthravadi D., Nichol S., RA Barker G., Whitehead S., Kay M., Brown J., Murnane C., Gray E., RA Humphries M., Sycamore N., Barker D., Saunders D., Wallis J., Babbage A., RA Hammond S., Mashreghi-Mohammadi M., Barr L., Martin S., Wray P., RA Ellington A., Matthews N., Ellwood M., Woodmansey R., Clark G., Cooper J., RA Tromans A., Grafham D., Skuce C., Pandian R., Andrews R., Harrison E., RA Kimberley A., Garnett J., Fosker N., Hall R., Garner P., Kelly D., Bird C., RA Palmer S., Gehring I., Berger A., Dooley C.M., Ersan-Urun Z., Eser C., RA Geiger H., Geisler M., Karotki L., Kirn A., Konantz J., Konantz M., RA Oberlander M., Rudolph-Geiger S., Teucke M., Lanz C., Raddatz G., RA Osoegawa K., Zhu B., Rapp A., Widaa S., Langford C., Yang F., RA Schuster S.C., Carter N.P., Harrow J., Ning Z., Herrero J., Searle S.M., RA Enright A., Geisler R., Plasterk R.H., Lee C., Westerfield M., RA de Jong P.J., Zon L.I., Postlethwait J.H., Nusslein-Volhard C., RA Hubbard T.J., Roest Crollius H., Rogers J., Stemple D.L.; RT "The zebrafish reference genome sequence and its relationship to the human RT genome."; RL Nature 496:498-503(2013). CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|RuleBase:RU000406}. CC -!- SIMILARITY: Belongs to the insulin family. CC {ECO:0000256|ARBA:ARBA00009034, ECO:0000256|RuleBase:RU000406}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; BX546473; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AY834223; AAX39710.1; -; mRNA. DR EMBL; EU437454; ACA13585.1; -; mRNA. DR RefSeq; NP_001032892.1; NM_001037803.1. DR STRING; 7955.ENSDARP00000082236; -. DR Ensembl; ENSDART00000087803; ENSDARP00000082236; ENSDARG00000070780. DR GeneID; 503864; -. DR KEGG; dre:503864; -. DR CTD; 503864; -. DR ZFIN; ZDB-GENE-050310-3; rln3a. DR eggNOG; ENOG502S2Z0; Eukaryota. DR GeneTree; ENSGT00940000154396; -. DR HOGENOM; CLU_120043_0_0_1; -. DR OMA; PWKANPI; -. DR OrthoDB; 1354498at2759; -. DR TreeFam; TF333404; -. DR Reactome; R-DRE-418555; G alpha (s) signalling events. DR Reactome; R-DRE-418594; G alpha (i) signalling events. DR Reactome; R-DRE-444821; Relaxin receptors. DR Proteomes; UP000000437; Chromosome 3. DR Bgee; ENSDARG00000070780; Expressed in brain and 23 other tissues. DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell. DR GO; GO:0001664; F:G protein-coupled receptor binding; IBA:GO_Central. DR GO; GO:0005179; F:hormone activity; IEA:InterPro. DR InterPro; IPR016179; Insulin-like. DR InterPro; IPR036438; Insulin-like_sf. DR InterPro; IPR022353; Insulin_CS. DR InterPro; IPR022352; Insulin_family. DR Pfam; PF00049; Insulin; 1. DR PRINTS; PR00276; INSULINFAMLY. DR SMART; SM00078; IlGF; 1. DR SUPFAM; SSF56994; SSF56994; 1. DR PROSITE; PS00262; INSULIN; 1. PE 1: Evidence at protein level; KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157}; KW Proteomics identification {ECO:0007829|PeptideAtlas:Q2VT45}; KW Reference proteome {ECO:0000313|Proteomes:UP000000437}; KW Secreted {ECO:0000256|RuleBase:RU000406}; Signal {ECO:0000256|SAM:SignalP}. FT SIGNAL 1..19 FT /evidence="ECO:0000256|SAM:SignalP" FT CHAIN 20..152 FT /evidence="ECO:0000256|SAM:SignalP" FT /id="PRO_5015097351" FT DOMAIN 28..152 FT /note="IlGF" FT /evidence="ECO:0000259|SMART:SM00078" SQ SEQUENCE 152 AA; 16155 MW; FD17964AE9F5E73E CRC64; MMWKTSALVV CLLLAGVKAL DAGPSYGVKL CGREFIRAVI FTCGGSRWKR SLTNTDEILD LFNSYDSNAA DGSVLFGSAS SSSQHATDSN LPPLGQGEQD GSVFSRPARS LISEEVLEAL RSVDRKGRDV VVGLSNACCK WGCSKGEISS LC //