ID   Q2V6T4_LEIBR            Unreviewed;       428 AA.
AC   Q2V6T4;
DT   10-JAN-2006, integrated into UniProtKB/TrEMBL.
DT   10-JAN-2006, sequence version 1.
DT   31-OCT-2006, entry version 9.
DE   Mannose phosphate isomerase.
OS   Leishmania braziliensis.
OC   Eukaryota; Euglenozoa; Kinetoplastida; Trypanosomatidae; Leishmania;
OC   Leishmania braziliensis species complex.
OX   NCBI_TaxID=5660;
RN   [1]
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=MHOM/BR/91/2195;
RA   Zhang W.-W., Miranda-Verastegui C., Matlashewski G.;
RT   "Development of a genetic assay to distinguish between Leishmania
RT   (Viannia) species based on isoenzyme differences.";
RL   Clin. Infect. Dis. 0:0-0(2006).
CC   -!- FUNCTION: Involved in the synthesis of the GDP-mannose and
CC       dolichol-phosphate-mannose required for a number of critical
CC       mannosyl transfer reactions (By similarity).
CC   -!- CATALYTIC ACTIVITY: D-mannose 6-phosphate = D-fructose 6-
CC       phosphate.
CC   -!- COFACTOR: Binds 1 zinc ion per subunit (By similarity).
CC   -!- PATHWAY: Glycosylation; early steps of mannosylation.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm (By similarity).
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DR   EMBL; DQ288169; ABB91670.1; -; Genomic_DNA.
DR   GO; GO:0016853; F:isomerase activity; IEA:UniProtKB-KW.
DR   GO; GO:0004476; F:mannose-6-phosphate isomerase activity; IEA:InterPro.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   GO; GO:0005975; P:carbohydrate metabolism; IEA:InterPro.
DR   InterPro; IPR011051; Cupin_RmlC_type.
DR   InterPro; IPR001250; Man6P_isomerase-1.
DR   Pfam; PF01238; PMI_typeI; 1.
DR   PRINTS; PR00714; MAN6PISMRASE.
DR   TIGRFAMs; TIGR00218; manA; 1.
DR   PROSITE; PS00965; PMI_I_1; 1.
DR   PROSITE; PS00966; PMI_I_2; 1.
KW   Isomerase; Metal-binding; Zinc.
SQ   SEQUENCE   428 AA;  47177 MW;  25A4B6CD6199D19D CRC64;
     MSALIKLDAS YQDYAWGKNA ASSFVAKMKG LTEDQSGKMY AELWVGTHPS CPSKVANGSA
     QLLEDFLKDP ENKKRYFSAA HQSTSFRDTV PYLLKILSIR TALSIQAHPC KKLAEELHAA
     QPDKYKDPNH KPELICALTP FEALCCFRPL KEIIAYLKRI PQLAALVAAD TVLGSYMMAP
     QSALPAADSD AERQSLKSLM TNLYAAPEDT VTKELRLHLR HIEEKGAQCA EDTLFVRIYK
     QYPDDVGCWM VYFLNYVQMV PGEALFLSDS EPHAYISGDG VEIMACSDNV VRAGLTPKWK
     DVPTLVSMLK YSTTGLASAR FEKNCSEDAA QWQVQCYQPP AQFPDFCLYR MQYDHTSGSG
     TTSVTLPTIG LGFCLEGSAR VNGTVVCAGD CFAVPYGKVT CQAEERKALV FVASTNDLSG
     TCPNSLRE
//