ID   Q2V6T4_LEIBR            Unreviewed;       428 AA.
AC   Q2V6T4;
DT   10-JAN-2006, integrated into UniProtKB/TrEMBL.
DT   10-JAN-2006, sequence version 1.
DT   11-NOV-2015, entry version 83.
DE   RecName: Full=Mannose-6-phosphate isomerase {ECO:0000256|RuleBase:RU000611};
DE            EC=5.3.1.8 {ECO:0000256|RuleBase:RU000611};
GN   Name=mpi {ECO:0000313|EMBL:ABY50483.1};
GN   Synonyms=MPI {ECO:0000313|EMBL:ABU25178.1}, PMI
GN   {ECO:0000313|EMBL:CAM42970.1};
GN   ORFNames=LBRM_32_1750 {ECO:0000313|EMBL:CAM42970.1};
OS   Leishmania braziliensis.
OC   Eukaryota; Euglenozoa; Kinetoplastida; Trypanosomatidae;
OC   Leishmaniinae; Leishmania; Leishmania braziliensis species complex.
OX   NCBI_TaxID=5660 {ECO:0000313|EMBL:ABB91670.1};
RN   [1] {ECO:0000313|EMBL:ABB91670.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=MHOM/BR/91/2195 {ECO:0000313|EMBL:ABB91670.1};
RX   PubMed=16477557; DOI=10.1086/500326;
RA   Zhang W.-W., Miranda-Verastegui C., Matlashewski G.;
RT   "Development of a genetic assay to distinguish between Leishmania
RT   viannia species on the basis of isoenzyme differences.";
RL   Clin. Infect. Dis. 42:801-809(2006).
RN   [2] {ECO:0000313|EMBL:CAM42970.1, ECO:0000313|Proteomes:UP000007258}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=MHOM/BR/75/M2904 {ECO:0000313|EMBL:CAM42970.1,
RC   ECO:0000313|Proteomes:UP000007258};
RX   PubMed=17572675; DOI=10.1038/ng2053;
RA   Peacock C.S., Seeger K., Harris D., Murphy L., Ruiz J.C., Quail M.A.,
RA   Peters N., Adlem E., Tivey A., Aslett M., Kerhornou A., Ivens A.,
RA   Fraser A., Rajandream M.-A., Carver T., Norbertczak H.,
RA   Chillingworth T., Hance Z., Jagels K., Moule S., Ormond D., Rutter S.,
RA   Sqaures R., Whitehead S., Rabbinowitsch E., Arrowsmith C., White B.,
RA   Thurston S., Bringaud F., Baldauf S.L., Faulconbridge A., Jeffares D.,
RA   Depledge D.P., Oyola S.O., Hilley J.D., Brito L.O., Tosi L.R.O.,
RA   Barrell B., Cruz A.K., Mottram J.C., Smith D.F., Berriman M.;
RT   "Comparative genomic analysis of three Leishmania species that cause
RT   diverse human disease.";
RL   Nat. Genet. 39:839-847(2007).
RN   [3] {ECO:0000313|EMBL:ABY50483.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=MHOM/PE/93/LEH0022 {ECO:0000313|EMBL:ABY50504.1},
RC   MHOM/PE/93/LEH1642 {ECO:0000313|EMBL:ABY50485.1}, and
RC   MHOM/PE/94/LEH1829 {ECO:0000313|EMBL:ABY50483.1};
RA   Tsukayama P., Bacon D.J.;
RT   "Genetic evidence of sexual recombination in new world Leishmania
RT   populations from the sequence analysis of three isoenzyme markers.";
RL   Submitted (DEC-2007) to the EMBL/GenBank/DDBJ databases.
RN   [4] {ECO:0000313|EMBL:ABU25178.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=MHOM/PE/88/BAA2072 {ECO:0000313|EMBL:ABU25178.1};
RX   PubMed=18817779; DOI=10.1016/j.ijpara.2008.08.004;
RA   Tsukayama P., Lucas C., Bacon D.J.;
RT   "Typing of four genetic loci discriminates among closely related
RT   species of New World Leishmania.";
RL   Int. J. Parasitol. 39:355-362(2009).
RN   [5] {ECO:0000313|EMBL:CAM42970.1, ECO:0000313|Proteomes:UP000007258}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=MHOM/BR/75/M2904 {ECO:0000313|EMBL:CAM42970.1,
RC   ECO:0000313|Proteomes:UP000007258};
RX   PubMed=22038252; DOI=10.1101/gr.122945.111;
RA   Rogers M.B., Hilley J.D., Dickens N.J., Wilkes J., Bates P.A.,
RA   Depledge D.P., Harris D., Her Y., Herzyk P., Imamura H., Otto T.D.,
RA   Sanders M., Seeger K., Dujardin J.C., Berriman M., Smith D.F.,
RA   Hertz-Fowler C., Mottram J.C.;
RT   "Chromosome and gene copy number variation allow major structural
RT   change between species and strains of Leishmania.";
RL   Genome Res. 21:2129-2142(2011).
RN   [6] {ECO:0000313|EMBL:CAM42970.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=MHOM/BR/75/M2904 {ECO:0000313|EMBL:CAM42970.1};
RA   Aslett M.;
RL   Submitted (JAN-2011) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY: D-mannose 6-phosphate = D-fructose 6-
CC       phosphate. {ECO:0000256|RuleBase:RU000611}.
CC   -!- COFACTOR:
CC       Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC         Evidence={ECO:0000256|PIRSR:PIRSR001480-2,
CC         ECO:0000256|RuleBase:RU000611};
CC       Note=Binds 1 zinc ion per subunit. {ECO:0000256|PIRSR:PIRSR001480-
CC       2, ECO:0000256|RuleBase:RU000611};
CC   -!- SIMILARITY: Belongs to the mannose-6-phosphate isomerase type 1
CC       family. {ECO:0000256|RuleBase:RU004189}.
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DR   EMBL; DQ288169; ABB91670.1; -; Genomic_DNA.
DR   EMBL; EU053117; ABU25178.1; -; Genomic_DNA.
DR   EMBL; EU327893; ABY50483.1; -; Genomic_DNA.
DR   EMBL; EU327895; ABY50485.1; -; Genomic_DNA.
DR   EMBL; EU327892; ABY50504.1; -; Genomic_DNA.
DR   EMBL; FR799007; CAM42970.1; -; Genomic_DNA.
DR   RefSeq; XP_001567530.1; XM_001567480.1.
DR   STRING; 420245.XP_001567530.1; -.
DR   EnsemblProtists; CAM42970; CAM42970; LBRM_32_1750.
DR   GeneID; 5418456; -.
DR   KEGG; lbz:LBRM_32_1750; -.
DR   eggNOG; KOG2757; Eukaryota.
DR   eggNOG; COG1482; LUCA.
DR   KO; K01809; -.
DR   OMA; AFCEVDE; -.
DR   Proteomes; UP000007258; Chromosome 32.
DR   GO; GO:0004476; F:mannose-6-phosphate isomerase activity; IEA:UniProtKB-EC.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   GO; GO:0005975; P:carbohydrate metabolic process; IEA:InterPro.
DR   GO; GO:0009298; P:GDP-mannose biosynthetic process; IEA:InterPro.
DR   Gene3D; 2.60.120.10; -; 3.
DR   InterPro; IPR001250; Man6P_Isoase-1.
DR   InterPro; IPR016305; Mannose-6-P_Isomerase.
DR   InterPro; IPR018050; Pmannose_isomerase-type1_CS.
DR   InterPro; IPR014710; RmlC-like_jellyroll.
DR   InterPro; IPR011051; RmlC_Cupin.
DR   PANTHER; PTHR10309; PTHR10309; 1.
DR   Pfam; PF01238; PMI_typeI; 1.
DR   PIRSF; PIRSF001480; Mannose-6-phosphate_isomerase; 1.
DR   PRINTS; PR00714; MAN6PISMRASE.
DR   SUPFAM; SSF51182; SSF51182; 1.
DR   TIGRFAMs; TIGR00218; manA; 1.
DR   PROSITE; PS00965; PMI_I_1; 1.
DR   PROSITE; PS00966; PMI_I_2; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000007258};
KW   Isomerase {ECO:0000256|RuleBase:RU000611,
KW   ECO:0000313|EMBL:ABB91670.1};
KW   Metal-binding {ECO:0000256|PIRSR:PIRSR001480-2};
KW   Reference proteome {ECO:0000313|Proteomes:UP000007258};
KW   Zinc {ECO:0000256|PIRSR:PIRSR001480-2, ECO:0000256|RuleBase:RU000611}.
FT   ACT_SITE    292    292       {ECO:0000256|PIRSR:PIRSR001480-1}.
FT   METAL       106    106       Zinc. {ECO:0000256|PIRSR:PIRSR001480-2}.
FT   METAL       108    108       Zinc. {ECO:0000256|PIRSR:PIRSR001480-2}.
FT   METAL       133    133       Zinc. {ECO:0000256|PIRSR:PIRSR001480-2}.
FT   METAL       273    273       Zinc. {ECO:0000256|PIRSR:PIRSR001480-2}.
SQ   SEQUENCE   428 AA;  47177 MW;  25A4B6CD6199D19D CRC64;
     MSALIKLDAS YQDYAWGKNA ASSFVAKMKG LTEDQSGKMY AELWVGTHPS CPSKVANGSA
     QLLEDFLKDP ENKKRYFSAA HQSTSFRDTV PYLLKILSIR TALSIQAHPC KKLAEELHAA
     QPDKYKDPNH KPELICALTP FEALCCFRPL KEIIAYLKRI PQLAALVAAD TVLGSYMMAP
     QSALPAADSD AERQSLKSLM TNLYAAPEDT VTKELRLHLR HIEEKGAQCA EDTLFVRIYK
     QYPDDVGCWM VYFLNYVQMV PGEALFLSDS EPHAYISGDG VEIMACSDNV VRAGLTPKWK
     DVPTLVSMLK YSTTGLASAR FEKNCSEDAA QWQVQCYQPP AQFPDFCLYR MQYDHTSGSG
     TTSVTLPTIG LGFCLEGSAR VNGTVVCAGD CFAVPYGKVT CQAEERKALV FVASTNDLSG
     TCPNSLRE
//