ID Q2V6T4_LEIBR PRELIMINARY; PRT; 428 AA. AC Q2V6T4; DT 10-JAN-2006, integrated into UniProtKB/TrEMBL. DT 10-JAN-2006, sequence version 1. DT 27-JUN-2006, entry version 8. DE Mannose phosphate isomerase. OS Leishmania braziliensis. OC Eukaryota; Euglenozoa; Kinetoplastida; Trypanosomatidae; Leishmania; OC Leishmania braziliensis species complex. OX NCBI_TaxID=5660; RN [1] RP NUCLEOTIDE SEQUENCE. RC STRAIN=MHOM/BR/91/2195; RA Zhang W.-W., Miranda-Verastegui C., Matlashewski G.; RT "Development of a genetic assay to distinguish between Leishmania RT (Viannia) species based on isoenzyme differences."; RL Clin. Infect. Dis. 0:0-0(2006). CC -!- FUNCTION: Involved in the synthesis of the GDP-mannose and CC dolichol-phosphate-mannose required for a number of critical CC mannosyl transfer reactions (By similarity). CC -!- CATALYTIC ACTIVITY: D-mannose 6-phosphate = D-fructose 6- CC phosphate. CC -!- COFACTOR: Binds 1 zinc ion per subunit (By similarity). CC -!- PATHWAY: Glycosylation; early steps of mannosylation. CC -!- SUBCELLULAR LOCATION: Cytoplasm (By similarity). CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; DQ288169; ABB91670.1; -; Genomic_DNA. DR GO; GO:0016853; F:isomerase activity; IEA. DR GO; GO:0004476; F:mannose-6-phosphate isomerase activity; IEA. DR GO; GO:0046872; F:metal ion binding; IEA. DR GO; GO:0008270; F:zinc ion binding; IEA. DR GO; GO:0005975; P:carbohydrate metabolism; IEA. DR InterPro; IPR011051; Cupin_RmlC_type. DR InterPro; IPR001250; Man6P_isomerase-1. DR Pfam; PF01238; PMI_typeI; 1. DR PRINTS; PR00714; MAN6PISMRASE. DR TIGRFAMs; TIGR00218; manA; 1. DR PROSITE; PS00965; PMI_I_1; 1. DR PROSITE; PS00966; PMI_I_2; 1. KW Isomerase; Metal-binding; Zinc. SQ SEQUENCE 428 AA; 47177 MW; 25A4B6CD6199D19D CRC64; MSALIKLDAS YQDYAWGKNA ASSFVAKMKG LTEDQSGKMY AELWVGTHPS CPSKVANGSA QLLEDFLKDP ENKKRYFSAA HQSTSFRDTV PYLLKILSIR TALSIQAHPC KKLAEELHAA QPDKYKDPNH KPELICALTP FEALCCFRPL KEIIAYLKRI PQLAALVAAD TVLGSYMMAP QSALPAADSD AERQSLKSLM TNLYAAPEDT VTKELRLHLR HIEEKGAQCA EDTLFVRIYK QYPDDVGCWM VYFLNYVQMV PGEALFLSDS EPHAYISGDG VEIMACSDNV VRAGLTPKWK DVPTLVSMLK YSTTGLASAR FEKNCSEDAA QWQVQCYQPP AQFPDFCLYR MQYDHTSGSG TTSVTLPTIG LGFCLEGSAR VNGTVVCAGD CFAVPYGKVT CQAEERKALV FVASTNDLSG TCPNSLRE //