ID Q2V6T4_LEIBR Unreviewed; 428 AA. AC Q2V6T4; DT 10-JAN-2006, integrated into UniProtKB/TrEMBL. DT 10-JAN-2006, sequence version 1. DT 11-JUN-2014, entry version 68. DE RecName: Full=Mannose-6-phosphate isomerase; DE EC=5.3.1.8; GN Name=mpi; Synonyms=MPI, PMI; ORFNames=LBRM_32_1750; OS Leishmania braziliensis. OC Eukaryota; Euglenozoa; Kinetoplastida; Trypanosomatidae; OC Leishmaniinae; Leishmania; Leishmania braziliensis species complex. OX NCBI_TaxID=5660; RN [1] RP NUCLEOTIDE SEQUENCE. RC STRAIN=MHOM/BR/91/2195; RX PubMed=16477557; DOI=10.1086/500326; RA Zhang W.-W., Miranda-Verastegui C., Matlashewski G.; RT "Development of a genetic assay to distinguish between Leishmania RT viannia species on the basis of isoenzyme differences."; RL Clin. Infect. Dis. 42:801-809(2006). RN [2] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=MHOM/BR/75/M2904; RX PubMed=17572675; DOI=10.1038/ng2053; RA Peacock C.S., Seeger K., Harris D., Murphy L., Ruiz J.C., Quail M.A., RA Peters N., Adlem E., Tivey A., Aslett M., Kerhornou A., Ivens A., RA Fraser A., Rajandream M.A., Carver T., Norbertczak H., RA Chillingworth T., Hance Z., Jagels K., Moule S., Ormond D., Rutter S., RA Squares R., Whitehead S., Rabbinowitsch E., Arrowsmith C., White B., RA Thurston S., Bringaud F., Baldauf S.L., Faulconbridge A., Jeffares D., RA Depledge D.P., Oyola S.O., Hilley J.D., Brito L.O., Tosi L.R., RA Barrell B., Cruz A.K., Mottram J.C., Smith D.F., Berriman M.; RT "Comparative genomic analysis of three Leishmania species that cause RT diverse human disease."; RL Nat. Genet. 39:839-847(2007). RN [3] RP NUCLEOTIDE SEQUENCE. RC STRAIN=MHOM/PE/93/LEH0022, MHOM/PE/93/LEH1642, and MHOM/PE/94/LEH1829; RA Tsukayama P., Bacon D.J.; RT "Genetic evidence of sexual recombination in new world Leishmania RT populations from the sequence analysis of three isoenzyme markers."; RL Submitted (DEC-2007) to the EMBL/GenBank/DDBJ databases. RN [4] RP NUCLEOTIDE SEQUENCE. RC STRAIN=MHOM/PE/88/BAA2072; RX PubMed=18817779; DOI=10.1016/j.ijpara.2008.08.004; RA Tsukayama P., Lucas C., Bacon D.J.; RT "Typing of four genetic loci discriminates among closely related RT species of New World Leishmania."; RL Int. J. Parasitol. 39:355-362(2009). RN [5] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=MHOM/BR/75/M2904; RX PubMed=22038252; DOI=10.1101/gr.122945.111; RA Rogers M.B., Hilley J.D., Dickens N.J., Wilkes J., Bates P.A., RA Depledge D.P., Harris D., Her Y., Herzyk P., Imamura H., Otto T.D., RA Sanders M., Seeger K., Dujardin J.C., Berriman M., Smith D.F., RA Hertz-Fowler C., Mottram J.C.; RT "Chromosome and gene copy number variation allow major structural RT change between species and strains of Leishmania."; RL Genome Res. 21:2129-2142(2011). RN [6] RP NUCLEOTIDE SEQUENCE. RC STRAIN=MHOM/BR/75/M2904; RA Aslett M.; RL Submitted (JAN-2011) to the EMBL/GenBank/DDBJ databases. CC -!- CATALYTIC ACTIVITY: D-mannose 6-phosphate = D-fructose 6- CC phosphate. CC -!- COFACTOR: Binds 1 zinc ion per subunit (By similarity). CC -!- SIMILARITY: Belongs to the mannose-6-phosphate isomerase type 1 CC family. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; DQ288169; ABB91670.1; -; Genomic_DNA. DR EMBL; EU053117; ABU25178.1; -; Genomic_DNA. DR EMBL; EU327893; ABY50483.1; -; Genomic_DNA. DR EMBL; EU327895; ABY50485.1; -; Genomic_DNA. DR EMBL; EU327892; ABY50504.1; -; Genomic_DNA. DR EMBL; FR799007; CAM42970.1; -; Genomic_DNA. DR RefSeq; XP_001567530.1; XM_001567480.1. DR ProteinModelPortal; Q2V6T4; -. DR GeneID; 5418456; -. DR KEGG; lbz:LBRM_32_1750; -. DR KO; K01809; -. DR OMA; SEDAAQW; -. DR GO; GO:0004476; F:mannose-6-phosphate isomerase activity; IEA:UniProtKB-EC. DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro. DR GO; GO:0005975; P:carbohydrate metabolic process; IEA:InterPro. DR GO; GO:0009298; P:GDP-mannose biosynthetic process; IEA:InterPro. DR Gene3D; 2.60.120.10; -; 3. DR InterPro; IPR001250; Man6P_Isoase-1. DR InterPro; IPR016305; Mannose-6-P_Isomerase. DR InterPro; IPR018050; Pmannose_isomerase-type1_CS. DR InterPro; IPR014710; RmlC-like_jellyroll. DR InterPro; IPR011051; RmlC_Cupin. DR PANTHER; PTHR10309; PTHR10309; 1. DR Pfam; PF01238; PMI_typeI; 1. DR PIRSF; PIRSF001480; Mannose-6-phosphate_isomerase; 1. DR PRINTS; PR00714; MAN6PISMRASE. DR SUPFAM; SSF51182; SSF51182; 1. DR TIGRFAMs; TIGR00218; manA; 1. DR PROSITE; PS00965; PMI_I_1; 1. DR PROSITE; PS00966; PMI_I_2; 1. PE 3: Inferred from homology; KW Complete proteome; Isomerase; Reference proteome; Zinc. SQ SEQUENCE 428 AA; 47177 MW; 25A4B6CD6199D19D CRC64; MSALIKLDAS YQDYAWGKNA ASSFVAKMKG LTEDQSGKMY AELWVGTHPS CPSKVANGSA QLLEDFLKDP ENKKRYFSAA HQSTSFRDTV PYLLKILSIR TALSIQAHPC KKLAEELHAA QPDKYKDPNH KPELICALTP FEALCCFRPL KEIIAYLKRI PQLAALVAAD TVLGSYMMAP QSALPAADSD AERQSLKSLM TNLYAAPEDT VTKELRLHLR HIEEKGAQCA EDTLFVRIYK QYPDDVGCWM VYFLNYVQMV PGEALFLSDS EPHAYISGDG VEIMACSDNV VRAGLTPKWK DVPTLVSMLK YSTTGLASAR FEKNCSEDAA QWQVQCYQPP AQFPDFCLYR MQYDHTSGSG TTSVTLPTIG LGFCLEGSAR VNGTVVCAGD CFAVPYGKVT CQAEERKALV FVASTNDLSG TCPNSLRE //