ID Q2RTX4_RHORT Unreviewed; 349 AA. AC Q2RTX4; DT 24-JAN-2006, integrated into UniProtKB/TrEMBL. DT 24-JAN-2006, sequence version 1. DT 21-SEP-2011, entry version 42. DE RecName: Full=tRNA-dihydrouridine synthase; DE EC=1.-.-.-; GN OrderedLocusNames=Rru_A1621; OS Rhodospirillum rubrum (strain ATCC 11170 / NCIB 8255). OC Bacteria; Proteobacteria; Alphaproteobacteria; Rhodospirillales; OC Rhodospirillaceae; Rhodospirillum. OX NCBI_TaxID=269796; RN [1] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=ATCC 11170 / NCIB 8255; RA Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina T., RA Hammon N., Israni S., Pitluck S., Munk A.C., Brettin T., Bruce D., RA Han C., Tapia R., Gilna P., Schmutz J., Larimer F., Land M., RA Kyrpides N., Mavrommatis K., Richardson P., Zhang Y., Roberts G., RA Reslewic S., Zhou S., Schwartz D.C.; RT "Complete sequence of the chromosome of Rhodospirillum rubrum ATCC RT 11170."; RL Submitted (DEC-2005) to the EMBL/GenBank/DDBJ databases. CC -!- FUNCTION: Catalyzes the synthesis of dihydrouridine, a modified CC base found in the D-loop of most tRNAs (By similarity). CC -!- COFACTOR: FAD (By similarity). CC -!- SIMILARITY: Belongs to the dus family. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; CP000230; ABC22421.1; -; Genomic_DNA. DR RefSeq; YP_426708.1; NC_007643.1. DR ProteinModelPortal; Q2RTX4; -. DR STRING; Q2RTX4; -. DR GeneID; 3835038; -. DR GenomeReviews; CP000230_GR; Rru_A1621. DR KEGG; rru:Rru_A1621; -. DR NMPDR; fig|1085.1.peg.2745; -. DR eggNOG; COG0042; -. DR HOGENOM; HBG630545; -. DR OMA; RIGIDEQ; -. DR PhylomeDB; Q2RTX4; -. DR ProtClustDB; PRK11815; -. DR BioCyc; RRUB269796:RRU_A1621-MONOMER; -. DR GO; GO:0050660; F:flavin adenine dinucleotide binding; IEA:InterPro. DR GO; GO:0017150; F:tRNA dihydrouridine synthase activity; IEA:InterPro. DR GO; GO:0008033; P:tRNA processing; IEA:UniProtKB-KW. DR InterPro; IPR013785; Aldolase_TIM. DR InterPro; IPR004653; tRNA_dU_YjbN. DR InterPro; IPR001269; tRNA_hU_synthase. DR InterPro; IPR018517; tRNA_hU_synthase_CS. DR Gene3D; G3DSA:3.20.20.70; Aldolase_TIM; 1. DR PANTHER; PTHR11082; Du_synth; 1. DR Pfam; PF01207; Dus; 1. DR PIRSF; PIRSF006621; Dus; 1. DR TIGRFAMs; TIGR00742; YjbN; 1. DR PROSITE; PS01136; UPF0034; 1. PE 3: Inferred from homology; KW Complete proteome; FAD; Flavoprotein; Oxidoreductase; KW Reference proteome; tRNA processing. SQ SEQUENCE 349 AA; 37800 MW; 8697330561D649F3 CRC64; MMVSAPAPRS QPDRSQPDRR LSVAPMMDWT DRHDRWFLRQ ITKRTLLYTE MITAQALLHA DPGRFLDHHP DEHPLALQLG GSDPRALAEA TRLAAPFGFA EINLNVGCPS DRVSSGRFGA CLMADPALVA ECLSAMAEAS NAPVTIKHRI GIDDLDSYDQ LVGFVDQVAR SGIATIIVHA RKAWLKGLSP KENREIPPLR HDVVHRLKAD FPGLEVILNG GITTLTQALD HLGSGDPAAP AVDGVMIGRA AYETPYMLAQ ADGLIFGEAT PAPSRHEVAL ALLPYLDAMT ARGEPVKRLT RHILGLFHGQ PGARAYRRHL GEAGVRPDAT AQVLIDALAH IPALDEAES //