ID PTTG3_PONPY Reviewed; 202 AA. AC Q2QD14; DT 20-MAY-2008, integrated into UniProtKB/Swiss-Prot. DT 24-JAN-2006, sequence version 1. DT 02-JUN-2021, entry version 45. DE RecName: Full=Putative pituitary tumor-transforming gene 3 protein; DE AltName: Full=Securin-3; DE AltName: Full=rcPTTG1; GN Name=PTTG3; OS Pongo pygmaeus (Bornean orangutan). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; OC Pongo. OX NCBI_TaxID=9600; RN [1] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA]. RX PubMed=16201836; DOI=10.1371/journal.pbio.0030357; RA Marques A.C., Dupanloup I., Vinckenbosch N., Reymond A., Kaessmann H.; RT "Emergence of young human genes after a burst of retroposition in RT primates."; RL PLoS Biol. 3:E357-E357(2005). CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}. CC -!- DOMAIN: The N-terminal destruction box (D-box) acts as a recognition CC signal for degradation via the ubiquitin-proteasome pathway. CC {ECO:0000250}. CC -!- SIMILARITY: Belongs to the securin family. {ECO:0000305}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; DQ120703; ABC40665.1; -; Genomic_DNA. DR SMR; Q2QD14; -. DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell. DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell. DR GO; GO:0017124; F:SH3 domain binding; IEA:UniProtKB-KW. DR GO; GO:0051276; P:chromosome organization; IEA:InterPro. DR InterPro; IPR006940; Securin_separation_inhibitor. DR PANTHER; PTHR10418; PTHR10418; 1. DR Pfam; PF04856; Securin; 1. PE 3: Inferred from homology; KW Cytoplasm; Nucleus; Proto-oncogene; SH3-binding. FT CHAIN 1..202 FT /note="Putative pituitary tumor-transforming gene 3 FT protein" FT /id="PRO_0000333862" FT REGION 67..92 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT MOTIF 61..64 FT /note="D-box" FT /evidence="ECO:0000250" FT MOTIF 163..173 FT /note="SH3-binding" FT /evidence="ECO:0000250" FT COMPBIAS 70..92 FT /note="Polar residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" SQ SEQUENCE 202 AA; 21966 MW; 561560E9A4D18E4C CRC64; MATLIYVDKE NEEPGTLVAT KDGLKLGSGP SIKALDGRSQ VSTSRFGKTF DAATALPKAT RKALGTVNRA TEKSVKTNGP LKQKQPSFSA KKMTEKTVKA KSSVPASDDA YPEIEKLFPF NPLGFESFNL PEEHQIAHLP LSGVPLMILD EERELEKLFQ LGPPLPLKMP SPPWESNLLQ SPSSILLTLD VELPPVCSDI DI //