ID PTTG3_PONPY Reviewed; 202 AA. AC Q2QD14; DT 20-MAY-2008, integrated into UniProtKB/Swiss-Prot. DT 24-JAN-2006, sequence version 1. DT 10-JUN-2008, entry version 11. DE Securin-3 (Pituitary tumor transforming gene 3 protein) (rcPTTG1). GN Name=PTTG3; OS Pongo pygmaeus (Bornean orangutan). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Pongo. OX NCBI_TaxID=9600; RN [1] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA]. RX PubMed=16201836; DOI=10.1371/journal.pbio.0030357; RA Marques A.C., Dupanloup I., Vinckenbosch N., Reymond A., Kaessmann H.; RT "Emergence of young human genes after a burst of retroposition in RT primates."; RL PLoS Biol. 3:1970-1979(2005). CC -!- SUBCELLULAR LOCATION: Cytoplasm (By similarity). Nucleus (By CC similarity). CC -!- DOMAIN: The N-terminal destruction box (D-box) acts as a CC recognition signal for degradation via the ubiquitin-proteasome CC pathway (By similarity). CC -!- SIMILARITY: Belongs to the securin family. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; DQ120703; ABC40665.1; -; Genomic_DNA. DR HOVERGEN; Q2QD14; -. DR InterPro; IPR006940; Securin. DR PANTHER; PTHR10418; Securin; 1. DR Pfam; PF04856; Securin; 1. PE 3: Inferred from homology; KW Cytoplasm; Nucleus; Proto-oncogene; SH3-binding. FT CHAIN 1 202 Securin-3. FT /FTId=PRO_0000333862. FT MOTIF 61 64 D-box (By similarity). FT MOTIF 163 173 SH3-binding (By similarity). SQ SEQUENCE 202 AA; 21966 MW; 561560E9A4D18E4C CRC64; MATLIYVDKE NEEPGTLVAT KDGLKLGSGP SIKALDGRSQ VSTSRFGKTF DAATALPKAT RKALGTVNRA TEKSVKTNGP LKQKQPSFSA KKMTEKTVKA KSSVPASDDA YPEIEKLFPF NPLGFESFNL PEEHQIAHLP LSGVPLMILD EERELEKLFQ LGPPLPLKMP SPPWESNLLQ SPSSILLTLD VELPPVCSDI DI //