ID Q2Q0K7_DROME Unreviewed; 311 AA. AC Q2Q0K7; DT 24-JAN-2006, integrated into UniProtKB/TrEMBL. DT 24-JAN-2006, sequence version 1. DT 13-SEP-2023, entry version 83. DE SubName: Full=R2D2 {ECO:0000313|EMBL:ABB77177.1}; GN Name=r2d2 {ECO:0000313|FlyBase:FBgn0031951}; GN ORFNames=CG7138 {ECO:0000313|FlyBase:FBgn0031951}; OS Drosophila melanogaster (Fruit fly). OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; OC Drosophilidae; Drosophila; Sophophora. OX NCBI_TaxID=7227 {ECO:0000313|EMBL:ABB77177.1}; RN [1] {ECO:0000313|EMBL:ABB77177.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=G196 {ECO:0000313|EMBL:ABB77177.1}; RX PubMed=16546082; DOI=10.1016/j.cub.2006.01.065; RA Obbard D.J., Jiggins F.M., Halligan D.L., Little T.J.; RT "Natural selection drives extremely rapid evolution in antiviral RNAi RT genes."; RL Curr. Biol. 16:580-585(2006). CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; DQ252345; ABB77177.1; -; Genomic_DNA. DR AlphaFoldDB; Q2Q0K7; -. DR SMR; Q2Q0K7; -. DR PeptideAtlas; Q2Q0K7; -. DR AGR; FB:FBgn0031951; -. DR FlyBase; FBgn0031951; r2d2. DR VEuPathDB; VectorBase:FBgn0031951; -. DR HOGENOM; CLU_075162_0_0_1; -. DR ExpressionAtlas; Q2Q0K7; baseline and differential. DR GO; GO:0005737; C:cytoplasm; IDA:FlyBase. DR GO; GO:0005634; C:nucleus; IDA:FlyBase. DR GO; GO:0016442; C:RISC complex; IBA:GO_Central. DR GO; GO:0070578; C:RISC-loading complex; IBA:GO_Central. DR GO; GO:0003725; F:double-stranded RNA binding; ISS:FlyBase. DR GO; GO:0035197; F:siRNA binding; IBA:GO_Central. DR GO; GO:0051607; P:defense response to virus; IMP:FlyBase. DR GO; GO:0030713; P:follicle cell of egg chamber stalk formation; IMP:FlyBase. DR GO; GO:0070920; P:regulation of regulatory ncRNA processing; IDA:FlyBase. DR GO; GO:0070918; P:regulatory ncRNA processing; IDA:FlyBase. DR GO; GO:0070922; P:RISC complex assembly; IDA:FlyBase. DR GO; GO:0030422; P:siRNA processing; IDA:FlyBase. DR CDD; cd00048; DSRM_SF; 2. DR Gene3D; 3.30.160.20; -; 2. DR InterPro; IPR014720; dsRBD_dom. DR PANTHER; PTHR46205:SF4; LD06392P; 1. DR PANTHER; PTHR46205; LOQUACIOUS, ISOFORM B; 1. DR Pfam; PF00035; dsrm; 2. DR SMART; SM00358; DSRM; 2. DR SUPFAM; SSF54768; dsRNA-binding domain-like; 2. DR PROSITE; PS50137; DS_RBD; 2. PE 4: Predicted; KW RNA-binding {ECO:0000256|PROSITE-ProRule:PRU00266}. FT DOMAIN 5..69 FT /note="DRBM" FT /evidence="ECO:0000259|PROSITE:PS50137" FT DOMAIN 95..163 FT /note="DRBM" FT /evidence="ECO:0000259|PROSITE:PS50137" SQ SEQUENCE 311 AA; 35043 MW; 65FF56CE07A830A1 CRC64; MDNKSAVSAL QEFCARTQIN LPTYSFIPGE DGGYVCKVEL LEIEALGNGR SKRDAKHLAA SNILRKIQLL PGIHGLMKDS TVGDLDEELT NLNRDMVKEL RDYCVRREMP LPCIEVVQQS GTPSAPEFVA CCSVASIVRY GKSDKKKDAR QRAAIEMLAL ISSNSDNLRP DQMQVASTSK LKVVDMEESM EELEASRRKK FTTYWELKEA GSVDHTGMRL CDRHNYFKNF YPTLKKEAIE AINSDEYESS KDKAMDVMSS LKITPKISEV ESSSLVPLLS VELNCAFDVV LMAKETDIYD HIIDYFRTML I //