ID Q2Q0K7_DROME Unreviewed; 311 AA. AC Q2Q0K7; DT 24-JAN-2006, integrated into UniProtKB/TrEMBL. DT 24-JAN-2006, sequence version 1. DT 01-OCT-2014, entry version 48. DE SubName: Full=R2D2 {ECO:0000313|EMBL:ABB77177.1}; GN Name=r2d2 {ECO:0000313|FlyBase:FBgn0031951}; GN ORFNames=CG7138 {ECO:0000313|FlyBase:FBgn0031951}; OS Drosophila melanogaster (Fruit fly). OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; OC Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; OC Ephydroidea; Drosophilidae; Drosophila; Sophophora. OX NCBI_TaxID=7227; RN [1] {ECO:0000313|EMBL:ABB77177.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=G196 {ECO:0000313|EMBL:ABB77177.1}; RX PubMed=16546082; DOI=10.1016/j.cub.2006.01.065; RA Obbard D.J., Jiggins F.M., Halligan D.L., Little T.J.; RT "Natural selection drives extremely rapid evolution in antiviral RNAi RT genes."; RL Curr. Biol. 16:580-585(2006). CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; DQ252345; ABB77177.1; -; Genomic_DNA. DR ProteinModelPortal; Q2Q0K7; -. DR SMR; Q2Q0K7; 3-68, 93-165. DR PaxDb; Q2Q0K7; -. DR PRIDE; Q2Q0K7; -. DR FlyBase; FBgn0031951; r2d2. DR eggNOG; NOG278868; -. DR InParanoid; Q2Q0K7; -. DR OrthoDB; EOG7NW69C; -. DR Bgee; Q2Q0K7; -. DR GO; GO:0005737; C:cytoplasm; IDA:FlyBase. DR GO; GO:0005634; C:nucleus; IDA:FlyBase. DR GO; GO:0016442; C:RISC complex; IDA:FlyBase. DR GO; GO:0003725; F:double-stranded RNA binding; ISS:FlyBase. DR GO; GO:0051607; P:defense response to virus; IMP:FlyBase. DR GO; GO:0070868; P:heterochromatin organization involved in chromatin silencing; IMP:FlyBase. DR GO; GO:0030713; P:ovarian follicle cell stalk formation; IMP:FlyBase. DR GO; GO:0030422; P:production of siRNA involved in RNA interference; IDA:FlyBase. DR GO; GO:0070918; P:production of small RNA involved in gene silencing by RNA; IDA:FlyBase. DR GO; GO:0070920; P:regulation of production of small RNA involved in gene silencing by RNA; IDA:FlyBase. DR GO; GO:0035087; P:siRNA loading onto RISC involved in RNA interference; IDA:FlyBase. DR Gene3D; 3.30.160.20; -; 2. DR InterPro; IPR014720; dsRNA-bd_dom. DR Pfam; PF00035; dsrm; 2. DR SMART; SM00358; DSRM; 2. DR PROSITE; PS50137; DS_RBD; 2. PE 4: Predicted; SQ SEQUENCE 311 AA; 35043 MW; 65FF56CE07A830A1 CRC64; MDNKSAVSAL QEFCARTQIN LPTYSFIPGE DGGYVCKVEL LEIEALGNGR SKRDAKHLAA SNILRKIQLL PGIHGLMKDS TVGDLDEELT NLNRDMVKEL RDYCVRREMP LPCIEVVQQS GTPSAPEFVA CCSVASIVRY GKSDKKKDAR QRAAIEMLAL ISSNSDNLRP DQMQVASTSK LKVVDMEESM EELEASRRKK FTTYWELKEA GSVDHTGMRL CDRHNYFKNF YPTLKKEAIE AINSDEYESS KDKAMDVMSS LKITPKISEV ESSSLVPLLS VELNCAFDVV LMAKETDIYD HIIDYFRTML I //