ID TECT2_MOUSE Reviewed; 700 AA. AC Q2MV57; Q6PDZ5; Q8C0B3; Q9CXF5; DT 04-APR-2006, integrated into UniProtKB/Swiss-Prot. DT 04-APR-2006, sequence version 2. DT 15-JAN-2008, entry version 18. DE Tectonic-2 precursor. GN Name=Tctn2; Synonyms=Tect2; OS Mus musculus (Mouse). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; OC Muroidea; Muridae; Murinae; Mus. OX NCBI_TaxID=10090; RN [1] RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1). RC STRAIN=C57BL/6; RX PubMed=16357211; DOI=10.1101/gad.1363606; RA Reiter J.F., Skarnes W.C.; RT "Tectonic, a novel regulator of the Hedgehog pathway required for both RT activation and inhibition."; RL Genes Dev. 20:22-27(2006). RN [2] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). RC STRAIN=C57BL/6J; TISSUE=Liver, and Medulla oblongata; RX PubMed=16141072; DOI=10.1126/science.1112014; RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., RA Davis M.J., Wilming L.G., Aidinis V., Allen J.E., RA Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., RA Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., RA Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., RA Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., RA di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., RA Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., RA Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., RA Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., RA Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., RA Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., RA Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., RA Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., RA Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., RA Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., RA Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., RA Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., RA Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., RA Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., RA Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., RA Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., RA Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., RA Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., RA Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., RA Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., RA Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., RA Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., RA Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., RA Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., RA Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., RA Hayashizaki Y.; RT "The transcriptional landscape of the mammalian genome."; RL Science 309:1559-1563(2005). RN [3] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2). RC STRAIN=C57BL/6; TISSUE=Brain; RX PubMed=15489334; DOI=10.1101/gr.2596504; RG The MGC Project Team; RT "The status, quality, and expansion of the NIH full-length cDNA RT project: the Mammalian Gene Collection (MGC)."; RL Genome Res. 14:2121-2127(2004). CC -!- SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane CC protein (Potential). CC -!- ALTERNATIVE PRODUCTS: CC Event=Alternative splicing; Named isoforms=2; CC Name=1; CC IsoId=Q2MV57-1; Sequence=Displayed; CC Name=2; CC IsoId=Q2MV57-2; Sequence=VSP_017766; CC Note=No experimental confirmation available; CC -!- SIMILARITY: Belongs to the tectonic family. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; DQ278869; ABB90561.1; -; mRNA. DR EMBL; AK014476; BAB29379.1; -; mRNA. DR EMBL; AK031829; BAC27569.1; -; mRNA. DR EMBL; BC058375; AAH58375.1; -; mRNA. DR RefSeq; NP_080762.1; -. DR UniGene; Mm.93193; -. DR Ensembl; ENSMUSG00000029386; Mus musculus. DR GeneID; 67978; -. DR KEGG; mmu:67978; -. DR MGI; MGI:1915228; Tctn2. DR ArrayExpress; Q2MV57; -. DR CleanEx; MM_TCTN2; -. DR GermOnline; ENSMUSG00000029386; Mus musculus. DR InterPro; IPR011677; DUF1619. DR Pfam; PF07773; DUF1619; 1. PE 2: Evidence at transcript level; KW Alternative splicing; Glycoprotein; Membrane; Signal; Transmembrane. FT SIGNAL 1 25 Potential. FT CHAIN 26 700 Tectonic-2. FT /FTId=PRO_0000229799. FT TOPO_DOM 26 665 Extracellular (Potential). FT TRANSMEM 666 682 Potential. FT TOPO_DOM 683 700 Cytoplasmic (Potential). FT COMPBIAS 171 190 Cys-rich. FT CARBOHYD 76 76 N-linked (GlcNAc...) (Potential). FT CARBOHYD 82 82 N-linked (GlcNAc...) (Potential). FT CARBOHYD 146 146 N-linked (GlcNAc...) (Potential). FT CARBOHYD 156 156 N-linked (GlcNAc...) (Potential). FT VAR_SEQ 1 121 Missing (in isoform 2). FT /FTId=VSP_017766. FT CONFLICT 42 42 R -> Q (in Ref. 1). FT CONFLICT 57 57 S -> T (in Ref. 1). FT CONFLICT 79 79 V -> E (in Ref. 1). FT CONFLICT 272 272 D -> E (in Ref. 2; BAC27569). SQ SEQUENCE 700 AA; 77111 MW; 59B1C3A973EFD581 CRC64; MGSLSPLSLL WGLLLLQGVL RPLRGDPVFI PPFIRMSSPE VRATLVGGSE DVAVSLSLLQ VEEGVLPVPT CGGRRNETVD WNVTVSPRES TLEVTIRWKR GLDWCSADET ASFSEPPCVL QMLLVSASHN ASCLAHLLIQ VEIYPNTSVT HNASENMTVI PNQVYQPLGP CPCDLTAKAC DIQCCCDQDC QPEVRELFAQ SCFSGVFGGH VSPPSHHHCA VSTTHQTPDW FPLLCVQSPP STSPFLGHFY HGATSPRHSP GFEAHLHFDL RDFADASYKQ GDPIMTTEGY FTIPQVSLAG QCLQDAPVAF LRNFDSVCTM DLEVHQGRDE IVLENMKIRT TGGPVTPTVT YEEAIDLDKF ITSPDTVLSV GSAPRNVNVE EHYVFRWQNN SISGLDITVI RAEISAQQRG MMTQRFTVKF LSHHSGGEKE FSGNPGYQLG KPVRALHTAG MNVSTLHLWQ PAGRGLCTAA ALRPILFGEN AFSGCLLEVG IKENCTQLRE NVLQRLDLLT QATHVARRGN SDYSDLSDGW LEIIRAEAPD TGADLPLSSV NGVCPEVPAR LSIRILTAEA GSVEGVAQRE ILAVETRFST VTWQYQCGLT CEDKADLLPL SASVEFINVP AQMPHPPTRF QINFTEYDCT RNELCWPQLL YPLTQYYQGE PQSQCVAKGL MLLSLLMLAI LLRHPWVRMC KARDSAAIYH //