ID SC5A9_HUMAN Reviewed; 681 AA. AC Q2M3M2; B3KY87; B7ZL47; E9PAK4; Q5TET3; DT 20-MAY-2008, integrated into UniProtKB/Swiss-Prot. DT 20-MAY-2008, sequence version 2. DT 16-OCT-2013, entry version 70. DE RecName: Full=Sodium/glucose cotransporter 4; DE Short=Na(+)/glucose cotransporter 4; DE Short=hSGLT4; DE AltName: Full=Solute carrier family 5 member 9; GN Name=SLC5A9; Synonyms=SGLT4; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606; RN [1] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), FUNCTION, TISSUE RP SPECIFICITY, AND VARIANT MET-269. RC TISSUE=Intestine; RX PubMed=15607332; DOI=10.1016/j.lfs.2004.10.016; RA Tazawa S., Yamato T., Fujikura H., Hiratochi M., Itoh F., Tomae M., RA Takemura Y., Maruyama H., Sugiyama T., Wakamatsu A., Isogai T., RA Isaji M.; RT "SLC5A9/SGLT4, a new Na+-dependent glucose transporter, is an RT essential transporter for mannose, 1,5-anhydro-D-glucitol, and RT fructose."; RL Life Sci. 76:1039-1050(2005). RN [2] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=16710414; DOI=10.1038/nature04727; RA Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., RA Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., RA Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., RA McDonald L., Evans R., Phillips K., Atkinson A., Cooper R., Jones C., RA Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., RA Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., RA Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., RA Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., RA Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., RA Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., RA Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., RA Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., RA Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., RA Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., RA Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., RA Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., RA Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., RA Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., RA Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., RA Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., RA Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., RA Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., RA Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., RA Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., RA Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., RA Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., RA Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., RA Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., RA Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., RA Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., RA Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., RA Beck S., Rogers J., Bentley D.R.; RT "The DNA sequence and biological annotation of human chromosome 1."; RL Nature 441:315-321(2006). RN [3] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND VARIANT MET-269. RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., RA Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., RA Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., RA Hannenhalli S., Turner R., Yooseph S., Lu F., Nusskern D.R., RA Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., RA Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., RA Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., RA Venter J.C.; RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases. RN [4] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2), AND RP VARIANTS ILE-124 AND MET-269. RC TISSUE=Lung; RX PubMed=15489334; DOI=10.1101/gr.2596504; RG The MGC Project Team; RT "The status, quality, and expansion of the NIH full-length cDNA RT project: the Mammalian Gene Collection (MGC)."; RL Genome Res. 14:2121-2127(2004). CC -!- FUNCTION: Involved in sodium-dependent transport of D-mannose, D- CC glucose and D-fructose. CC -!- SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein CC (Potential). CC -!- ALTERNATIVE PRODUCTS: CC Event=Alternative splicing; Named isoforms=2; CC Name=1; CC IsoId=Q2M3M2-1; Sequence=Displayed; CC Name=2; CC IsoId=Q2M3M2-2; Sequence=VSP_044577; CC Note=No experimental confirmation available; CC -!- TISSUE SPECIFICITY: Expressed in the small intestine, kidney and CC liver. CC -!- SIMILARITY: Belongs to the sodium:solute symporter (SSF) CC (TC 2.A.21) family. CC -!- SEQUENCE CAUTION: CC Sequence=CAI18915.1; Type=Erroneous gene model prediction; CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AK131200; BAG54749.1; -; mRNA. DR EMBL; AL109659; CAI18915.1; ALT_SEQ; Genomic_DNA. DR EMBL; CH471059; EAX06857.1; -; Genomic_DNA. DR EMBL; BC104857; AAI04858.1; -; mRNA. DR EMBL; BC104863; AAI04864.1; -; mRNA. DR EMBL; BC143572; AAI43573.1; -; mRNA. DR IPI; IPI00299501; -. DR IPI; IPI00913999; -. DR RefSeq; NP_001011547.2; NM_001011547.2. DR RefSeq; NP_001128653.1; NM_001135181.1. DR UniGene; Hs.37890; -. DR ProteinModelPortal; Q2M3M2; -. DR SMR; Q2M3M2; 37-511. DR TCDB; 2.A.21.3.17; the solute:sodium symporter (sss) family. DR DMDM; 189046189; -. DR PaxDb; Q2M3M2; -. DR PRIDE; Q2M3M2; -. DR Ensembl; ENST00000236495; ENSP00000236495; ENSG00000117834. DR Ensembl; ENST00000438567; ENSP00000401730; ENSG00000117834. DR GeneID; 200010; -. DR KEGG; hsa:200010; -. DR UCSC; uc001crn.2; human. DR CTD; 200010; -. DR GeneCards; GC01P048688; -. DR H-InvDB; HIX0023625; -. DR H-InvDB; HIX0029229; -. DR HGNC; HGNC:22146; SLC5A9. DR HPA; HPA050263; -. DR neXtProt; NX_Q2M3M2; -. DR PharmGKB; PA134949681; -. DR eggNOG; COG4146; -. DR HOGENOM; HOG000025422; -. DR HOVERGEN; HBG052859; -. DR KO; K14389; -. DR OMA; FLGFQDV; -. DR Reactome; REACT_111217; Metabolism. DR Reactome; REACT_15518; Transmembrane transport of small molecules. DR GenomeRNAi; 200010; -. DR NextBio; 35481237; -. DR PRO; PR:Q2M3M2; -. DR ArrayExpress; Q2M3M2; -. DR Bgee; Q2M3M2; -. DR CleanEx; HS_SLC5A9; -. DR Genevestigator; Q2M3M2; -. DR GO; GO:0016021; C:integral to membrane; IEA:UniProtKB-KW. DR GO; GO:0005886; C:plasma membrane; TAS:Reactome. DR GO; GO:0005215; F:transporter activity; IEA:InterPro. DR GO; GO:0006814; P:sodium ion transport; IEA:UniProtKB-KW. DR GO; GO:0055085; P:transmembrane transport; TAS:Reactome. DR InterPro; IPR001734; Na/solute_symporter. DR InterPro; IPR018212; Na/solute_symporter_CS. DR InterPro; IPR019900; Na/solute_symporter_subgr. DR PANTHER; PTHR11819; PTHR11819; 1. DR Pfam; PF00474; SSF; 1. DR TIGRFAMs; TIGR00813; sss; 1. DR PROSITE; PS00456; NA_SOLUT_SYMP_1; 1. DR PROSITE; PS00457; NA_SOLUT_SYMP_2; FALSE_NEG. DR PROSITE; PS50283; NA_SOLUT_SYMP_3; 1. PE 2: Evidence at transcript level; KW Alternative splicing; Complete proteome; Glycoprotein; Ion transport; KW Membrane; Polymorphism; Reference proteome; Sodium; Sodium transport; KW Transmembrane; Transmembrane helix; Transport. FT CHAIN 1 681 Sodium/glucose cotransporter 4. FT /FTId=PRO_0000333805. FT TOPO_DOM 1 36 Extracellular (Potential). FT TRANSMEM 37 57 Helical; (Potential). FT TOPO_DOM 58 75 Cytoplasmic (Potential). FT TRANSMEM 76 98 Helical; (Potential). FT TOPO_DOM 99 114 Extracellular (Potential). FT TRANSMEM 115 135 Helical; (Potential). FT TOPO_DOM 136 157 Cytoplasmic (Potential). FT TRANSMEM 158 178 Helical; (Potential). FT TOPO_DOM 179 190 Extracellular (Potential). FT TRANSMEM 191 211 Helical; (Potential). FT TOPO_DOM 212 217 Cytoplasmic (Potential). FT TRANSMEM 218 238 Helical; (Potential). FT TOPO_DOM 239 275 Extracellular (Potential). FT TRANSMEM 276 296 Helical; (Potential). FT TOPO_DOM 297 317 Cytoplasmic (Potential). FT TRANSMEM 318 338 Helical; (Potential). FT TOPO_DOM 339 383 Extracellular (Potential). FT TRANSMEM 384 406 Helical; (Potential). FT TOPO_DOM 407 427 Cytoplasmic (Potential). FT TRANSMEM 428 448 Helical; (Potential). FT TOPO_DOM 449 459 Extracellular (Potential). FT TRANSMEM 460 480 Helical; (Potential). FT TOPO_DOM 481 487 Cytoplasmic (Potential). FT TRANSMEM 488 508 Helical; (Potential). FT TOPO_DOM 509 530 Extracellular (Potential). FT TRANSMEM 531 551 Helical; (Potential). FT TOPO_DOM 552 660 Cytoplasmic (Potential). FT TRANSMEM 661 681 Helical; (Potential). FT CARBOHYD 251 251 N-linked (GlcNAc...) (Potential). FT VAR_SEQ 113 113 N -> NMRKSRSGGDRGIHPRSHGRTGVRSQ (in FT isoform 2). FT /FTId=VSP_044577. FT VARIANT 124 124 V -> I (in dbSNP:rs141515954). FT /FTId=VAR_068963. FT VARIANT 152 152 V -> M (in dbSNP:rs212989). FT /FTId=VAR_043166. FT VARIANT 207 207 M -> T (in dbSNP:rs12047252). FT /FTId=VAR_043167. FT VARIANT 269 269 I -> M (in dbSNP:rs212991). FT /FTId=VAR_043168. SQ SEQUENCE 681 AA; 74073 MW; 618D27DC590EE826 CRC64; MSKELAAMGP GASGDGVRTE TAPHIALDSR VGLHAYDISV VVIYFVFVIA VGIWSSIRAS RGTIGGYFLA GRSMSWWPIG ASLMSSNVGS GLFIGLAGTG AAGGLAVGGF EWNATWLLLA LGWVFVPVYI AAGVVTMPQY LKKRFGGQRI QVYMSVLSLI LYIFTKISTD IFSGALFIQM ALGWNLYLST GILLVVTAVY TIAGGLMAVI YTDALQTVIM VGGALVLMFL GFQDVGWYPG LEQRYRQAIP NVTVPNTTCH LPRPDAFHIL RDPVSGDIPW PGLIFGLTVL ATWCWCTDQV IVQRSLSAKS LSHAKGGSVL GGYLKILPMF FIVMPGMISR ALFPDEVGCV DPDVCQRICG ARVGCSNIAY PKLVMALMPV GLRGLMIAVI MAALMSSLTS IFNSSSTLFT IDVWQRFRRK STEQELMVVG RVFVVFLVVI SILWIPIIQS SNSGQLFDYI QAVTSYLAPP ITALFLLAIF CKRVTEPGAF WGLVFGLGVG LLRMILEFSY PAPACGEVDR RPAVLKDFHY LYFAILLCGL TAIVIVIVSL CTTPIPEEQL TRLTWWTRNC PLSELEKEAH ESTPEISERP AGECPAGGGA AENSSLGQEQ PEAPSRSWGK LLWSWFCGLS GTPEQALSPA EKAALEQKLT SIEEEPLWRH VCNINAVLLL AINIFLWGYF A //