ID SC5A9_HUMAN Reviewed; 681 AA. AC Q2M3M2; B3KY87; B7ZL45; B7ZL47; E9PAK4; E9PJ08; Q5TET3; DT 20-MAY-2008, integrated into UniProtKB/Swiss-Prot. DT 20-MAY-2008, sequence version 2. DT 10-FEB-2021, entry version 129. DE RecName: Full=Sodium/glucose cotransporter 4; DE Short=Na(+)/glucose cotransporter 4; DE Short=hSGLT4; DE AltName: Full=Solute carrier family 5 member 9; GN Name=SLC5A9; Synonyms=SGLT4; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; OC Homo. OX NCBI_TaxID=9606; RN [1] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), FUNCTION, TISSUE RP SPECIFICITY, AND VARIANT MET-269. RC TISSUE=Intestine; RX PubMed=15607332; DOI=10.1016/j.lfs.2004.10.016; RA Tazawa S., Yamato T., Fujikura H., Hiratochi M., Itoh F., Tomae M., RA Takemura Y., Maruyama H., Sugiyama T., Wakamatsu A., Isogai T., Isaji M.; RT "SLC5A9/SGLT4, a new Na+-dependent glucose transporter, is an essential RT transporter for mannose, 1,5-anhydro-D-glucitol, and fructose."; RL Life Sci. 76:1039-1050(2005). RN [2] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=16710414; DOI=10.1038/nature04727; RA Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., RA Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., RA Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K., RA Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., RA Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., RA Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., RA Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., RA Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., RA Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., RA Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., RA Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., RA Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., RA Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., RA Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., RA Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., RA Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., RA Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., RA Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., RA Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., RA McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., RA Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., RA Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., RA Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., RA Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., RA Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., RA White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., RA Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., RA Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., RA Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.; RT "The DNA sequence and biological annotation of human chromosome 1."; RL Nature 441:315-321(2006). RN [3] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND VARIANT MET-269. RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., RA Hunkapiller M.W., Myers E.W., Venter J.C.; RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases. RN [4] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 2 AND 3), AND VARIANTS RP ILE-124 AND MET-269. RC TISSUE=Lung; RX PubMed=15489334; DOI=10.1101/gr.2596504; RG The MGC Project Team; RT "The status, quality, and expansion of the NIH full-length cDNA project: RT the Mammalian Gene Collection (MGC)."; RL Genome Res. 14:2121-2127(2004). RN [5] RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-604 AND SER-605, AND RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RC TISSUE=Liver; RX PubMed=24275569; DOI=10.1016/j.jprot.2013.11.014; RA Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., Wang L., RA Ye M., Zou H.; RT "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver RT phosphoproteome."; RL J. Proteomics 96:253-262(2014). CC -!- FUNCTION: Involved in sodium-dependent transport of D-mannose, D- CC glucose and D-fructose. {ECO:0000269|PubMed:15607332}. CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane CC protein {ECO:0000305}. CC -!- ALTERNATIVE PRODUCTS: CC Event=Alternative splicing; Named isoforms=3; CC Name=1; CC IsoId=Q2M3M2-1; Sequence=Displayed; CC Name=2; CC IsoId=Q2M3M2-2; Sequence=VSP_044577; CC Name=3; CC IsoId=Q2M3M2-3; Sequence=VSP_057168; CC -!- TISSUE SPECIFICITY: Expressed in the small intestine, kidney and liver. CC {ECO:0000269|PubMed:15607332}. CC -!- SIMILARITY: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) CC family. {ECO:0000305}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AK131200; BAG54749.1; -; mRNA. DR EMBL; AL109659; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; CH471059; EAX06857.1; -; Genomic_DNA. DR EMBL; BC104857; AAI04858.1; -; mRNA. DR EMBL; BC104863; AAI04864.1; -; mRNA. DR EMBL; BC143570; AAI43571.1; -; mRNA. DR EMBL; BC143572; AAI43573.1; -; mRNA. DR CCDS; CCDS30709.2; -. [Q2M3M2-1] DR CCDS; CCDS44136.1; -. [Q2M3M2-2] DR RefSeq; NP_001011547.2; NM_001011547.2. [Q2M3M2-1] DR RefSeq; NP_001128653.1; NM_001135181.1. [Q2M3M2-2] DR BioGRID; 128290; 2. DR STRING; 9606.ENSP00000236495; -. DR DrugCentral; Q2M3M2; -. DR TCDB; 2.A.21.3.17; the solute:sodium symporter (sss) family. DR GlyGen; Q2M3M2; 2 sites, 1 O-linked glycan (1 site). DR iPTMnet; Q2M3M2; -. DR PhosphoSitePlus; Q2M3M2; -. DR BioMuta; SLC5A9; -. DR DMDM; 189046189; -. DR jPOST; Q2M3M2; -. DR MassIVE; Q2M3M2; -. DR PaxDb; Q2M3M2; -. DR PeptideAtlas; Q2M3M2; -. DR PRIDE; Q2M3M2; -. DR ProteomicsDB; 19032; -. DR ProteomicsDB; 20981; -. DR ProteomicsDB; 61379; -. [Q2M3M2-1] DR Antibodypedia; 32891; 169 antibodies. DR Ensembl; ENST00000236495; ENSP00000236495; ENSG00000117834. [Q2M3M2-2] DR Ensembl; ENST00000438567; ENSP00000401730; ENSG00000117834. [Q2M3M2-1] DR Ensembl; ENST00000533824; ENSP00000431900; ENSG00000117834. [Q2M3M2-3] DR GeneID; 200010; -. DR KEGG; hsa:200010; -. DR UCSC; uc001crn.3; human. [Q2M3M2-1] DR CTD; 200010; -. DR DisGeNET; 200010; -. DR GeneCards; SLC5A9; -. DR HGNC; HGNC:22146; SLC5A9. DR HPA; ENSG00000117834; Tissue enriched (intestine). DR neXtProt; NX_Q2M3M2; -. DR OpenTargets; ENSG00000117834; -. DR PharmGKB; PA134949681; -. DR VEuPathDB; HostDB:ENSG00000117834.12; -. DR eggNOG; KOG2349; Eukaryota. DR GeneTree; ENSGT00940000157546; -. DR HOGENOM; CLU_018808_9_2_1; -. DR InParanoid; Q2M3M2; -. DR OMA; TINVFLW; -. DR OrthoDB; 243316at2759; -. DR PhylomeDB; Q2M3M2; -. DR TreeFam; TF352855; -. DR PathwayCommons; Q2M3M2; -. DR Reactome; R-HSA-189200; Cellular hexose transport. DR BioGRID-ORCS; 200010; 6 hits in 867 CRISPR screens. DR GenomeRNAi; 200010; -. DR Pharos; Q2M3M2; Tdark. DR PRO; PR:Q2M3M2; -. DR Proteomes; UP000005640; Chromosome 1. DR RNAct; Q2M3M2; protein. DR Bgee; ENSG00000117834; Expressed in duodenum and 126 other tissues. DR ExpressionAtlas; Q2M3M2; baseline and differential. DR Genevisible; Q2M3M2; HS. DR GO; GO:0070062; C:extracellular exosome; HDA:UniProtKB. DR GO; GO:0016021; C:integral component of membrane; IBA:GO_Central. DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central. DR GO; GO:0005412; F:glucose:sodium symporter activity; IBA:GO_Central. DR GO; GO:0005362; F:low-affinity glucose:sodium symporter activity; TAS:Reactome. DR GO; GO:0008645; P:hexose transmembrane transport; TAS:Reactome. DR GO; GO:0006814; P:sodium ion transport; IBA:GO_Central. DR Gene3D; 1.20.1730.10; -; 1. DR InterPro; IPR038377; Na/Glc_symporter_sf. DR InterPro; IPR001734; Na/solute_symporter. DR InterPro; IPR018212; Na/solute_symporter_CS. DR Pfam; PF00474; SSF; 1. DR TIGRFAMs; TIGR00813; sss; 1. DR PROSITE; PS00456; NA_SOLUT_SYMP_1; 1. DR PROSITE; PS50283; NA_SOLUT_SYMP_3; 1. PE 1: Evidence at protein level; KW Alternative splicing; Glycoprotein; Ion transport; Membrane; KW Phosphoprotein; Reference proteome; Sodium; Sodium transport; KW Transmembrane; Transmembrane helix; Transport. FT CHAIN 1..681 FT /note="Sodium/glucose cotransporter 4" FT /id="PRO_0000333805" FT TOPO_DOM 1..36 FT /note="Extracellular" FT /evidence="ECO:0000255" FT TRANSMEM 37..57 FT /note="Helical" FT /evidence="ECO:0000255" FT TOPO_DOM 58..75 FT /note="Cytoplasmic" FT /evidence="ECO:0000255" FT TRANSMEM 76..98 FT /note="Helical" FT /evidence="ECO:0000255" FT TOPO_DOM 99..114 FT /note="Extracellular" FT /evidence="ECO:0000255" FT TRANSMEM 115..135 FT /note="Helical" FT /evidence="ECO:0000255" FT TOPO_DOM 136..157 FT /note="Cytoplasmic" FT /evidence="ECO:0000255" FT TRANSMEM 158..178 FT /note="Helical" FT /evidence="ECO:0000255" FT TOPO_DOM 179..190 FT /note="Extracellular" FT /evidence="ECO:0000255" FT TRANSMEM 191..211 FT /note="Helical" FT /evidence="ECO:0000255" FT TOPO_DOM 212..217 FT /note="Cytoplasmic" FT /evidence="ECO:0000255" FT TRANSMEM 218..238 FT /note="Helical" FT /evidence="ECO:0000255" FT TOPO_DOM 239..275 FT /note="Extracellular" FT /evidence="ECO:0000255" FT TRANSMEM 276..296 FT /note="Helical" FT /evidence="ECO:0000255" FT TOPO_DOM 297..317 FT /note="Cytoplasmic" FT /evidence="ECO:0000255" FT TRANSMEM 318..338 FT /note="Helical" FT /evidence="ECO:0000255" FT TOPO_DOM 339..383 FT /note="Extracellular" FT /evidence="ECO:0000255" FT TRANSMEM 384..406 FT /note="Helical" FT /evidence="ECO:0000255" FT TOPO_DOM 407..427 FT /note="Cytoplasmic" FT /evidence="ECO:0000255" FT TRANSMEM 428..448 FT /note="Helical" FT /evidence="ECO:0000255" FT TOPO_DOM 449..459 FT /note="Extracellular" FT /evidence="ECO:0000255" FT TRANSMEM 460..480 FT /note="Helical" FT /evidence="ECO:0000255" FT TOPO_DOM 481..487 FT /note="Cytoplasmic" FT /evidence="ECO:0000255" FT TRANSMEM 488..508 FT /note="Helical" FT /evidence="ECO:0000255" FT TOPO_DOM 509..530 FT /note="Extracellular" FT /evidence="ECO:0000255" FT TRANSMEM 531..551 FT /note="Helical" FT /evidence="ECO:0000255" FT TOPO_DOM 552..660 FT /note="Cytoplasmic" FT /evidence="ECO:0000255" FT TRANSMEM 661..681 FT /note="Helical" FT /evidence="ECO:0000255" FT MOD_RES 604 FT /note="Phosphoserine" FT /evidence="ECO:0000244|PubMed:24275569" FT MOD_RES 605 FT /note="Phosphoserine" FT /evidence="ECO:0000244|PubMed:24275569" FT CARBOHYD 251 FT /note="N-linked (GlcNAc...) asparagine" FT /evidence="ECO:0000255" FT VAR_SEQ 113 FT /note="N -> NMRKSRSGGDRGIHPRSHGRTGVRSQ (in isoform 2)" FT /evidence="ECO:0000303|PubMed:15489334" FT /id="VSP_044577" FT VAR_SEQ 113 FT /note="N -> NMRKSRSGGDRGIHPRSHGRTG (in isoform 3)" FT /evidence="ECO:0000303|PubMed:15489334" FT /id="VSP_057168" FT VARIANT 124 FT /note="V -> I (in dbSNP:rs141515954)" FT /evidence="ECO:0000269|PubMed:15489334" FT /id="VAR_068963" FT VARIANT 152 FT /note="V -> M (in dbSNP:rs212989)" FT /id="VAR_043166" FT VARIANT 207 FT /note="M -> T (in dbSNP:rs12047252)" FT /id="VAR_043167" FT VARIANT 269 FT /note="I -> M (in dbSNP:rs212991)" FT /evidence="ECO:0000269|PubMed:15489334, FT ECO:0000269|PubMed:15607332, ECO:0000269|Ref.3" FT /id="VAR_043168" SQ SEQUENCE 681 AA; 74073 MW; 618D27DC590EE826 CRC64; MSKELAAMGP GASGDGVRTE TAPHIALDSR VGLHAYDISV VVIYFVFVIA VGIWSSIRAS RGTIGGYFLA GRSMSWWPIG ASLMSSNVGS GLFIGLAGTG AAGGLAVGGF EWNATWLLLA LGWVFVPVYI AAGVVTMPQY LKKRFGGQRI QVYMSVLSLI LYIFTKISTD IFSGALFIQM ALGWNLYLST GILLVVTAVY TIAGGLMAVI YTDALQTVIM VGGALVLMFL GFQDVGWYPG LEQRYRQAIP NVTVPNTTCH LPRPDAFHIL RDPVSGDIPW PGLIFGLTVL ATWCWCTDQV IVQRSLSAKS LSHAKGGSVL GGYLKILPMF FIVMPGMISR ALFPDEVGCV DPDVCQRICG ARVGCSNIAY PKLVMALMPV GLRGLMIAVI MAALMSSLTS IFNSSSTLFT IDVWQRFRRK STEQELMVVG RVFVVFLVVI SILWIPIIQS SNSGQLFDYI QAVTSYLAPP ITALFLLAIF CKRVTEPGAF WGLVFGLGVG LLRMILEFSY PAPACGEVDR RPAVLKDFHY LYFAILLCGL TAIVIVIVSL CTTPIPEEQL TRLTWWTRNC PLSELEKEAH ESTPEISERP AGECPAGGGA AENSSLGQEQ PEAPSRSWGK LLWSWFCGLS GTPEQALSPA EKAALEQKLT SIEEEPLWRH VCNINAVLLL AINIFLWGYF A //