ID Q2LCW8_9INFA Unreviewed; 328 AA. AC Q2LCW8; DT 21-FEB-2006, integrated into UniProtKB/TrEMBL. DT 21-FEB-2006, sequence version 1. DT 11-DEC-2013, entry version 49. DE SubName: Full=Hemagglutinin; DE Flags: Fragment; GN Name=HA1; OS Influenza A virus (A/Brazil/010/00(H3N2)). OC Viruses; ssRNA negative-strand viruses; Orthomyxoviridae; OC Influenzavirus A. OX NCBI_TaxID=365426; RN [1] RP NUCLEOTIDE SEQUENCE. RC STRAIN=A/Brazil/010/00; RA Golono M.A., Mayer M.G., Pereira A., Oliveira D.B.L., Araujo J., RA Vallada M.G., Durigon E.L., Becak W.; RT "Influenza A hemagglutinin variant, H3N2 subtype (HA1)."; RL Submitted (DEC-2005) to the EMBL/GenBank/DDBJ databases. CC -!- FUNCTION: Binds to sialic acid-containing receptors on the cell CC surface, bringing about the attachment of the virus particle to CC the cell. This attachment induces virion internalization of about CC two third of the virus particles through clathrin-dependent CC endocytosis and about one third through a clathrin- and caveolin- CC independent pathway. Plays a major role in the determination of CC host range restriction and virulence. Class I viral fusion CC protein. Responsible for penetration of the virus into the cell CC cytoplasm by mediating the fusion of the membrane of the CC endocytosed virus particle with the endosomal membrane. Low pH in CC endosomes induces an irreversible conformational change in HA2, CC releasing the fusion hydrophobic peptide. Several trimers are CC required to form a competent fusion pore (By similarity). CC -!- SUBUNIT: Homotrimer of disulfide-linked HA1-HA2 (By similarity). CC -!- SUBCELLULAR LOCATION: Virion membrane; Single-pass type I membrane CC protein. Host apical cell membrane; Single-pass type I membrane CC protein (By similarity). CC -!- SIMILARITY: Belongs to the influenza viruses hemagglutinin family. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; DQ336013; ABC66254.1; -; Genomic_RNA. DR GO; GO:0020002; C:host cell plasma membrane; IEA:UniProtKB-KW. DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW. DR GO; GO:0019031; C:viral envelope; IEA:UniProtKB-KW. DR GO; GO:0075512; P:clathrin-mediated endocytosis of virus by host cell; IEA:UniProtKB-KW. DR GO; GO:0039654; P:fusion of virus membrane with host endosome membrane; IEA:UniProtKB-KW. DR GO; GO:0019064; P:fusion of virus membrane with host plasma membrane; IEA:InterPro. DR GO; GO:0019048; P:modulation by virus of host morphology or physiology; IEA:UniProtKB-KW. DR GO; GO:0019062; P:viral attachment to host cell; IEA:UniProtKB-KW. DR Gene3D; 2.10.77.10; -; 1. DR Gene3D; 3.90.209.20; -; 1. DR InterPro; IPR008980; Capsid_hemagglutn. DR InterPro; IPR013828; Hemagglutn_HA1_a/b_dom. DR InterPro; IPR013827; Hemagglutn_HA1_b-rbn_dom. DR InterPro; IPR000149; Hemagglutn_influenz_A. DR InterPro; IPR001364; Hemagglutn_influenz_A/B. DR Pfam; PF00509; Hemagglutinin; 1. DR PRINTS; PR00330; HEMAGGLUTN1. DR PRINTS; PR00329; HEMAGGLUTN12. DR SUPFAM; SSF49818; SSF49818; 1. PE 3: Inferred from homology; KW Clathrin- and caveolin-independent endocytosis of virus by host; KW Clathrin-mediated endocytosis of virus by host; Disulfide bond; KW Fusion of virus membrane with host endosomal membrane; KW Fusion of virus membrane with host membrane; Hemagglutinin; KW Host cell membrane; Host membrane; Host-virus interaction; Membrane; KW Viral attachment to host cell; Viral envelope protein; KW Viral penetration into host cytoplasm; Virion; KW Virus endocytosis by host; Virus entry into host cell. FT NON_TER 1 1 FT NON_TER 328 328 SQ SEQUENCE 328 AA; 36418 MW; D12F8FF466F912CC CRC64; QKLPGNDNST ATLCLGHHAV PNGTLVKTIT NDQIEVTNAT ELVQSSSTGR ICDSPHRILD GKNCTLIDAL LGDPHCDGFQ NKEWDLFVER SKAYSNCYPY DVPDYASLRS LVASSGTLEF INEDFNWTGV AQSGESYACK RGSVKSFFSR LNWLHKSDYK YPALNVTMPN NGKFDKLYIW GVHHPSTDRE QTSLYVRASG RVTVSTKRSQ QTVIPNIGSR PWVRGLSSRI SIYWTIVKPG DILLINSTGN LIAPRGYFKI RTGKSSIMRS DAPIGTCSSE CITPNGSIPN DKPFQNVNRI TYGACPRYVK QNTLKLATGM RNVPEKQN //