ID Q2LCW8_9INFA Unreviewed; 328 AA. AC Q2LCW8; DT 21-FEB-2006, integrated into UniProtKB/TrEMBL. DT 21-FEB-2006, sequence version 1. DT 10-JUN-2008, entry version 14. DE Hemagglutinin (Fragment). GN Name=HA1; OS Influenza A virus (A/Brazil/010/00(H3N2)). OC Viruses; ssRNA negative-strand viruses; Orthomyxoviridae; OC Influenzavirus A. OX NCBI_TaxID=365426; RN [1] RP NUCLEOTIDE SEQUENCE. RC STRAIN=A/Brazil/010/00; RA Golono M.A., Mayer M.G., Pereira A., Oliveira D.B.L., Araujo J., RA Vallada M.G., Durigon E.L., Becak W.; RT "Influenza A hemagglutinin variant, H3N2 subtype (HA1)."; RL Submitted (DEC-2005) to the EMBL/GenBank/DDBJ databases. CC -!- FUNCTION: Binds to sialic acid-containing receptors on the cell CC surface, bringing about the attachment of the virus particle to CC the cell. Plays a major role in the determination of host range CC restriction and virulence. Class I viral fusion protein. CC Responsible for penetration of the virus into the cell cytoplasm CC by mediating the fusion of the membrane of the endocytosed virus CC particle with the endosomal membrane. Low pH in endosomes induce CC an irreversible conformational change in HA2, releasing the fusion CC hydrophobic peptide. Several trimers are required to form a CC competent fusion pore (By similarity). CC -!- SUBUNIT: Homotrimer of disulfide-linked HA1-HA2 (By similarity). CC -!- SIMILARITY: Belongs to the influenza viruses hemagglutinin family. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; DQ336013; ABC66254.1; -; Genomic_RNA. DR SMR; Q2LCW8; 1-327. DR GO; GO:0016324; C:apical plasma membrane; IEA:UniProtKB-SubCell. DR GO; GO:0016021; C:integral to membrane; IEA:UniProtKB-KW. DR GO; GO:0019031; C:viral envelope; IEA:InterPro. DR GO; GO:0046789; F:host cell surface receptor binding; IEA:InterPro. DR GO; GO:0019064; P:viral envelope fusion with host membrane; IEA:InterPro. DR InterPro; IPR013828; Hemagglutn_HA1_a/b. DR InterPro; IPR000149; Hemagglutn_influenz_HA1. DR InterPro; IPR001364; Hemagglutn_influenz_HA1/HA2. DR Gene3D; G3DSA:3.90.209.20; Haemagglutn_HA1_a/b; 1. DR Pfam; PF00509; Hemagglutinin; 1. DR PRINTS; PR00330; HEMAGGLUTN1. DR PRINTS; PR00329; HEMAGGLUTN12. DR ProDom; PD000225; Hemagglutn; 1. PE 3: Inferred from homology; KW Envelope protein; Fusion protein; Hemagglutinin; Membrane; KW Transmembrane; Virion. FT NON_TER 1 1 FT NON_TER 328 328 SQ SEQUENCE 328 AA; 36418 MW; D12F8FF466F912CC CRC64; QKLPGNDNST ATLCLGHHAV PNGTLVKTIT NDQIEVTNAT ELVQSSSTGR ICDSPHRILD GKNCTLIDAL LGDPHCDGFQ NKEWDLFVER SKAYSNCYPY DVPDYASLRS LVASSGTLEF INEDFNWTGV AQSGESYACK RGSVKSFFSR LNWLHKSDYK YPALNVTMPN NGKFDKLYIW GVHHPSTDRE QTSLYVRASG RVTVSTKRSQ QTVIPNIGSR PWVRGLSSRI SIYWTIVKPG DILLINSTGN LIAPRGYFKI RTGKSSIMRS DAPIGTCSSE CITPNGSIPN DKPFQNVNRI TYGACPRYVK QNTLKLATGM RNVPEKQN //