ID PIPNA_BOVIN Reviewed; 270 AA. AC Q2HJ54; Q9TR37; DT 12-DEC-2006, integrated into UniProtKB/Swiss-Prot. DT 23-JAN-2007, sequence version 3. DT 05-APR-2011, entry version 39. DE RecName: Full=Phosphatidylinositol transfer protein alpha isoform; DE Short=PI-TP-alpha; DE Short=PtdIns transfer protein alpha; DE Short=PtdInsTP alpha; DE AltName: Full=Phosphatidylinositol-transfer protein 35 kDa isoform; DE Short=PI-TP 35 kda isoform; GN Name=PITPNA; OS Bos taurus (Bovine). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Ruminantia; OC Pecora; Bovidae; Bovinae; Bos. OX NCBI_TaxID=9913; RN [1] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. RC STRAIN=Hereford; TISSUE=Uterus; RG NIH - Mammalian Gene Collection (MGC) project; RL Submitted (FEB-2006) to the EMBL/GenBank/DDBJ databases. RN [2] RP PROTEIN SEQUENCE OF 2-22. RC TISSUE=Brain; RX MEDLINE=95382786; PubMed=7654206; RA de Vries K.J., Heinrichs A.A., Cunningham E., Brunink F., RA Westerman J., Somerharju P.J., Cockcroft S., Wirtz K.W., Snoek G.T.; RT "An isoform of the phosphatidylinositol-transfer protein transfers RT sphingomyelin and is associated with the Golgi system."; RL Biochem. J. 310:643-649(1995). CC -!- FUNCTION: Catalyzes the transfer of PtdIns and phosphatidylcholine CC between membranes (By similarity). CC -!- SUBCELLULAR LOCATION: Cytoplasm (By similarity). CC -!- SIMILARITY: Belongs to the PtdIns transfer protein family. PI CC transfer class I subfamily. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; BC113306; AAI13307.1; -; mRNA. DR IPI; IPI00695148; -. DR PIR; A48214; A48214. DR PIR; S58431; S58431. DR RefSeq; NP_001040047.1; NM_001046582.1. DR UniGene; Bt.22547; -. DR ProteinModelPortal; Q2HJ54; -. DR SMR; Q2HJ54; 1-269. DR STRING; Q2HJ54; -. DR PRIDE; Q2HJ54; -. DR Ensembl; ENSBTAT00000046430; ENSBTAP00000043732; ENSBTAG00000011480. DR GeneID; 616550; -. DR KEGG; bta:616550; -. DR CTD; 616550; -. DR eggNOG; maNOG05283; -. DR GeneTree; ENSGT00550000074351; -. DR HOVERGEN; HBG058915; -. DR InParanoid; Q2HJ54; -. DR OMA; KLEPEAW; -. DR OrthoDB; EOG42JNS2; -. DR BioCyc; CATTLE:616550-MONOMER; -. DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell. DR GO; GO:0008289; F:lipid binding; IEA:UniProtKB-KW. DR GO; GO:0006810; P:transport; IEA:UniProtKB-KW. DR InterPro; IPR001666; PI_transfer. DR InterPro; IPR023393; START-like_dom. DR Gene3D; G3DSA:3.30.530.20; G3DSA:3.30.530.20; 1. DR PANTHER; PTHR10658; PI_transfer; 1. DR Pfam; PF02121; IP_trans; 1. DR PRINTS; PR00391; PITRANSFER. PE 1: Evidence at protein level; KW Acetylation; Cytoplasm; Direct protein sequencing; Lipid-binding; KW Phosphoprotein; Transport. FT INIT_MET 1 1 Removed. FT CHAIN 2 270 Phosphatidylinositol transfer protein FT alpha isoform. FT /FTId=PRO_0000269200. FT BINDING 58 58 Phosphatidylinositol lipid headgroup (By FT similarity). FT BINDING 60 60 Phosphatidylinositol lipid headgroup (By FT similarity). FT BINDING 85 85 Phosphatidylinositol lipid headgroup (By FT similarity). FT BINDING 89 89 Phosphatidylinositol lipid headgroup (By FT similarity). FT BINDING 96 96 Phosphatidylinositol lipid headgroup (By FT similarity). FT BINDING 194 194 Phosphatidylinositol lipid headgroup (By FT similarity). FT MOD_RES 57 57 Phosphotyrosine (By similarity). FT MOD_RES 215 215 N6-acetyllysine (By similarity). SQ SEQUENCE 270 AA; 31849 MW; FFE53A8F4D9F87CD CRC64; MVLLKEYRVI LPVSVEEYQV GQLYSVAEAS KNETGGGEGV EVLVNEPYEK DGEKGQYTHK IYHLQSKVPT FVRMLAPEGA LNIHEKAWNA YPYCRTVITN EYMKEDFLIK IETWHKPDLG TLENVHKLEP EAWKHVEVIY IDIADRSQVL SKDYKAEEDP AKYKSIKTGR GPLGPNWKQE LVNQKDCPYM CAYKLVTVKF KWWGLQNKVE NFIHKQERRL FTNFHRQLFC WLDKWVDLTM DDIRRMEDET KRQLDEMRQK DPVKGMTADD //