ID Q29FE8_DROPS Unreviewed; 1053 AA. AC Q29FE8; DT 04-APR-2006, integrated into UniProtKB/TrEMBL. DT 20-JAN-2016, sequence version 3. DT 19-JAN-2022, entry version 88. DE SubName: Full=Uncharacterized protein, isoform C {ECO:0000313|EMBL:EAL31307.3}; GN Name=Dpse\GA10064 {ECO:0000313|EMBL:EAL31307.3}; GN ORFNames=Dpse_GA10064 {ECO:0000313|EMBL:EAL31307.3}; OS Drosophila pseudoobscura pseudoobscura (Fruit fly). OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; OC Drosophilidae; Drosophila; Sophophora. OX NCBI_TaxID=46245 {ECO:0000313|EMBL:EAL31307.3}; RN [1] {ECO:0000313|EMBL:EAL31307.3} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=MV2-25 {ECO:0000313|EMBL:EAL31307.3}; RX PubMed=15632085; DOI=10.1101/gr.3059305; RA Richards S., Liu Y., Bettencourt B.R., Hradecky P., Letovsky S., RA Nielsen R., Thornton K., Hubisz M.J., Chen R., Meisel R.P., Couronne O., RA Hua S., Smith M.A., Zhang P., Liu J., Bussemaker H.J., van Batenburg M.F., RA Howells S.L., Scherer S.E., Sodergren E., Matthews B.B., Crosby M.A., RA Schroeder A.J., Ortiz-Barrientos D., Rives C.M., Metzker M.L., Muzny D.M., RA Scott G., Steffen D., Wheeler D.A., Worley K.C., Havlak P., Durbin K.J., RA Egan A., Gill R., Hume J., Morgan M.B., Miner G., Hamilton C., Huang Y., RA Waldron L., Verduzco D., Clerc-Blankenburg K.P., Dubchak I., Noor M.A., RA Anderson W., White K.P., Clark A.G., Schaeffer S.W., Gelbart W., RA Weinstock G.M., Gibbs R.A.; RT "Comparative genome sequencing of Drosophila pseudoobscura: chromosomal, RT gene, and cis-element evolution."; RL Genome Res. 15:1-18(2005). RN [2] {ECO:0000313|EMBL:EAL31307.3} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=MV2-25 {ECO:0000313|EMBL:EAL31307.3}; RX PubMed=17994087; DOI=10.1038/nature06341; RG Drosophila 12 genomes consortium; RA Clark A.G., Eisen M.B., Smith D.R., Bergman C.M., Oliver B., Markow T.A., RA Kaufman T.C., Kellis M., Gelbart W., Iyer V.N., Pollard D.A., Sackton T.B., RA Larracuente A.M., Singh N.D., Abad J.P., Abt D.N., Adryan B., Aguade M., RA Akashi H., Anderson W.W., Aquadro C.F., Ardell D.H., Arguello R., RA Artieri C.G., Barbash D.A., Barker D., Barsanti P., Batterham P., RA Batzoglou S., Begun D., Bhutkar A., Blanco E., Bosak S.A., Bradley R.K., RA Brand A.D., Brent M.R., Brooks A.N., Brown R.H., Butlin R.K., Caggese C., RA Calvi B.R., Bernardo de Carvalho A., Caspi A., Castrezana S., RA Celniker S.E., Chang J.L., Chapple C., Chatterji S., Chinwalla A., RA Civetta A., Clifton S.W., Comeron J.M., Costello J.C., Coyne J.A., Daub J., RA David R.G., Delcher A.L., Delehaunty K., Do C.B., Ebling H., Edwards K., RA Eickbush T., Evans J.D., Filipski A., Findeiss S., Freyhult E., Fulton L., RA Fulton R., Garcia A.C., Gardiner A., Garfield D.A., Garvin B.E., Gibson G., RA Gilbert D., Gnerre S., Godfrey J., Good R., Gotea V., Gravely B., RA Greenberg A.J., Griffiths-Jones S., Gross S., Guigo R., Gustafson E.A., RA Haerty W., Hahn M.W., Halligan D.L., Halpern A.L., Halter G.M., Han M.V., RA Heger A., Hillier L., Hinrichs A.S., Holmes I., Hoskins R.A., Hubisz M.J., RA Hultmark D., Huntley M.A., Jaffe D.B., Jagadeeshan S., Jeck W.R., RA Johnson J., Jones C.D., Jordan W.C., Karpen G.H., Kataoka E., RA Keightley P.D., Kheradpour P., Kirkness E.F., Koerich L.B., Kristiansen K., RA Kudrna D., Kulathinal R.J., Kumar S., Kwok R., Lander E., Langley C.H., RA Lapoint R., Lazzaro B.P., Lee S.J., Levesque L., Li R., Lin C.F., Lin M.F., RA Lindblad-Toh K., Llopart A., Long M., Low L., Lozovsky E., Lu J., Luo M., RA Machado C.A., Makalowski W., Marzo M., Matsuda M., Matzkin L., RA McAllister B., McBride C.S., McKernan B., McKernan K., Mendez-Lago M., RA Minx P., Mollenhauer M.U., Montooth K., Mount S.M., Mu X., Myers E., RA Negre B., Newfeld S., Nielsen R., Noor M.A., O'Grady P., Pachter L., RA Papaceit M., Parisi M.J., Parisi M., Parts L., Pedersen J.S., Pesole G., RA Phillippy A.M., Ponting C.P., Pop M., Porcelli D., Powell J.R., RA Prohaska S., Pruitt K., Puig M., Quesneville H., Ram K.R., Rand D., RA Rasmussen M.D., Reed L.K., Reenan R., Reily A., Remington K.A., RA Rieger T.T., Ritchie M.G., Robin C., Rogers Y.H., Rohde C., Rozas J., RA Rubenfield M.J., Ruiz A., Russo S., Salzberg S.L., Sanchez-Gracia A., RA Saranga D.J., Sato H., Schaeffer S.W., Schatz M.C., Schlenke T., RA Schwartz R., Segarra C., Singh R.S., Sirot L., Sirota M., Sisneros N.B., RA Smith C.D., Smith T.F., Spieth J., Stage D.E., Stark A., Stephan W., RA Strausberg R.L., Strempel S., Sturgill D., Sutton G., Sutton G.G., Tao W., RA Teichmann S., Tobari Y.N., Tomimura Y., Tsolas J.M., Valente V.L., RA Venter E., Venter J.C., Vicario S., Vieira F.G., Vilella A.J., RA Villasante A., Walenz B., Wang J., Wasserman M., Watts T., Wilson D., RA Wilson R.K., Wing R.A., Wolfner M.F., Wong A., Wong G.K., Wu C.I., Wu G., RA Yamamoto D., Yang H.P., Yang S.P., Yorke J.A., Yoshida K., Zdobnov E., RA Zhang P., Zhang Y., Zimin A.V., Baldwin J., Abdouelleil A., Abdulkadir J., RA Abebe A., Abera B., Abreu J., Acer S.C., Aftuck L., Alexander A., An P., RA Anderson E., Anderson S., Arachi H., Azer M., Bachantsang P., Barry A., RA Bayul T., Berlin A., Bessette D., Bloom T., Blye J., Boguslavskiy L., RA Bonnet C., Boukhgalter B., Bourzgui I., Brown A., Cahill P., Channer S., RA Cheshatsang Y., Chuda L., Citroen M., Collymore A., Cooke P., Costello M., RA D'Aco K., Daza R., De Haan G., DeGray S., DeMaso C., Dhargay N., Dooley K., RA Dooley E., Doricent M., Dorje P., Dorjee K., Dupes A., Elong R., Falk J., RA Farina A., Faro S., Ferguson D., Fisher S., Foley C.D., Franke A., RA Friedrich D., Gadbois L., Gearin G., Gearin C.R., Giannoukos G., Goode T., RA Graham J., Grandbois E., Grewal S., Gyaltsen K., Hafez N., Hagos B., RA Hall J., Henson C., Hollinger A., Honan T., Huard M.D., Hughes L., RA Hurhula B., Husby M.E., Kamat A., Kanga B., Kashin S., Khazanovich D., RA Kisner P., Lance K., Lara M., Lee W., Lennon N., Letendre F., LeVine R., RA Lipovsky A., Liu X., Liu J., Liu S., Lokyitsang T., Lokyitsang Y., RA Lubonja R., Lui A., MacDonald P., Magnisalis V., Maru K., Matthews C., RA McCusker W., McDonough S., Mehta T., Meldrim J., Meneus L., Mihai O., RA Mihalev A., Mihova T., Mittelman R., Mlenga V., Montmayeur A., Mulrain L., RA Navidi A., Naylor J., Negash T., Nguyen T., Nguyen N., Nicol R., Norbu C., RA Norbu N., Novod N., O'Neill B., Osman S., Markiewicz E., Oyono O.L., RA Patti C., Phunkhang P., Pierre F., Priest M., Raghuraman S., Rege F., RA Reyes R., Rise C., Rogov P., Ross K., Ryan E., Settipalli S., Shea T., RA Sherpa N., Shi L., Shih D., Sparrow T., Spaulding J., Stalker J., RA Stange-Thomann N., Stavropoulos S., Stone C., Strader C., Tesfaye S., RA Thomson T., Thoulutsang Y., Thoulutsang D., Topham K., Topping I., RA Tsamla T., Vassiliev H., Vo A., Wangchuk T., Wangdi T., Weiand M., RA Wilkinson J., Wilson A., Yadav S., Young G., Yu Q., Zembek L., Zhong D., RA Zimmer A., Zwirko Z., Jaffe D.B., Alvarez P., Brockman W., Butler J., RA Chin C., Gnerre S., Grabherr M., Kleber M., Mauceli E., MacCallum I.; RT "Evolution of genes and genomes on the Drosophila phylogeny."; RL Nature 450:203-218(2007). RN [3] {ECO:0000313|EMBL:EAL31307.3} RP NUCLEOTIDE SEQUENCE. RC STRAIN=MV2-25 {ECO:0000313|EMBL:EAL31307.3}; RX PubMed=23185243; DOI=10.1371/journal.pone.0047768; RA English A.C., Richards S., Han Y., Wang M., Vee V., Qu J., Qin X., RA Muzny D.M., Reid J.G., Worley K.C., Gibbs R.A.; RT "Mind the gap: upgrading genomes with Pacific Biosciences RS long-read RT sequencing technology."; RL PLoS ONE 7:E47768-E47768(2012). RN [4] {ECO:0000313|EMBL:EAL31307.3} RP NUCLEOTIDE SEQUENCE. RC STRAIN=MV2-25 {ECO:0000313|EMBL:EAL31307.3}; RG FlyBase; RL Submitted (NOV-2015) to the EMBL/GenBank/DDBJ databases. CC -!- COFACTOR: CC Name=Zn(2+); Xref=ChEBI:CHEBI:29105; CC Evidence={ECO:0000256|ARBA:ARBA00001947}; CC -!- SIMILARITY: Belongs to the peptidase M1 family. CC {ECO:0000256|ARBA:ARBA00010136}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; CH379067; EAL31307.3; -; Genomic_DNA. DR RefSeq; XP_001354254.3; XM_001354218.3. DR STRING; 7237.FBpp0277939; -. DR MEROPS; M01.A24; -. DR EnsemblMetazoa; FBtr0370650; FBpp0333001; FBgn0070123. DR KEGG; dpo:Dpse_GA10064; -. DR eggNOG; KOG1046; Eukaryota. DR HOGENOM; CLU_003705_0_1_1; -. DR InParanoid; Q29FE8; -. DR OMA; HVKQNRF; -. DR Bgee; FBgn0070123; Expressed in adult organism and 4 other tissues. DR GO; GO:0008237; F:metallopeptidase activity; IEA:UniProtKB-KW. DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro. DR CDD; cd09601; M1_APN-Q_like; 1. DR Gene3D; 1.10.390.10; -; 1. DR Gene3D; 2.60.40.1730; -; 1. DR InterPro; IPR045357; Aminopeptidase_N-like_N. DR InterPro; IPR042097; Aminopeptidase_N-like_N_sf. DR InterPro; IPR024571; ERAP1-like_C_dom. DR InterPro; IPR034016; M1_APN-typ. DR InterPro; IPR001930; Peptidase_M1. DR InterPro; IPR014782; Peptidase_M1_dom. DR InterPro; IPR027268; Peptidase_M4/M1_CTD_sf. DR Pfam; PF11838; ERAP1_C; 1. DR Pfam; PF01433; Peptidase_M1; 1. DR Pfam; PF17900; Peptidase_M1_N; 1. DR PRINTS; PR00756; ALADIPTASE. DR SUPFAM; SSF63737; SSF63737; 1. PE 3: Inferred from homology; KW Hydrolase {ECO:0000256|ARBA:ARBA00022801}; KW Metal-binding {ECO:0000256|ARBA:ARBA00022723}; KW Metalloprotease {ECO:0000256|ARBA:ARBA00023049}; KW Protease {ECO:0000256|ARBA:ARBA00022670}; KW Zinc {ECO:0000256|ARBA:ARBA00022833}. FT DOMAIN 203..387 FT /note="Peptidase_M1_N" FT /evidence="ECO:0000259|Pfam:PF17900" FT DOMAIN 422..639 FT /note="Peptidase_M1" FT /evidence="ECO:0000259|Pfam:PF01433" FT DOMAIN 720..1033 FT /note="ERAP1_C" FT /evidence="ECO:0000259|Pfam:PF11838" FT REGION 28..63 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" SQ SEQUENCE 1053 AA; 120070 MW; AE77BBC7502EB4CD CRC64; MYKNALRGGI RTAKQAWRLK NATRPIQSCY PATETQPQLL NTSENNSRKS TRSQNTSPSI FNNQKNCNVA NHYRLFANVS PSTLDKHSNA HLRRIETAHL NELLSSKQFV KVQKQFYRDY SSVSLGAPLK SSDAPLLGDL CNQYRAILAY TSADVVPGQK QGQPQHQQIR GAHKQQETRM QQQEEVGGMA QKLEFKRLPT NVVPKHYELL LQPDLEAFTF KGKTIVQVQV KKPTKQIVLN ALDIIIEEAQ LEFECTKMKA DRIVYSTDAE TATLEFEKVI PAETAGVLQM SFTGELNDKM KGFYRSKYFS ASGEERYAGV TQFEATDARR CFPCWDEPAI KATFDITLVV PKNRVALSNM PVKKEDDLEG GLRRVRFDRT PIMSTYLVAC VVGEYDFVEG KSEDGIIVRV FTPVGKREQG QFALDVATKV LPFYKDYFNI AYPLPKMDLI AISDFSAGAM ENWGLVTYRE TFVLVDPKNT SLMRKQSIAL TVGHEIAHQW FGNLVTMEWW THLWLNEGYA SFVEFLCVHH LFPEYDIWTQ FVTDMYTRAL ELDSLKNSHP IEVPVGHPSE IDEIFDEISY NKGASVIRML HDYIGEDDFR KGMNIYLTRH QYGNTSTEDL WTALQEASSK NVAEVMSSWT QYKGFPVVSV ESEQKGKTQR ILRLSQRKFT ADGSQADGDC LWVVPISVST SRDPTAIAKT FLLDKPSMEV VLDGVTDSDW IKINPGTVGY YRTRYSKEML EQLMPAVKNM ELPPLDRLGL IDDMFAMVQA GHASTADVLA LVDGYRNETN YTVWTAITNS LTNLHVLISH TDLMEDFHRF GRNLYEPVAQ RLGWEPREGE NHLDTLLRSL VLTRLVSFRS NDVIEVARQR FRSHINGTQP LPADLRTTCY KAALQDGNEQ IFEEMLALYR TTDLHEEQDR ISRALGCSTD AKLLRRVIDF AMSGEVRAQD SVFVIVAVAI NPKGRDMAWE FFKSSNKQLL ERYQGGFLLT RLIKYLIENY ASEEKAKEVE EFFRVTQIPG CERTVSQAVE TIRLNAAWLE RDREKLSTYL KSV //