ID Q29FE8_DROPS Unreviewed; 1053 AA. AC Q29FE8; DT 04-APR-2006, integrated into UniProtKB/TrEMBL. DT 20-JAN-2016, sequence version 3. DT 10-MAY-2017, entry version 65. DE RecName: Full=Aminopeptidase {ECO:0000256|RuleBase:RU364040}; DE EC=3.4.11.- {ECO:0000256|RuleBase:RU364040}; GN Name=Dpse\GA10064 {ECO:0000313|EMBL:EAL31307.3}; GN ORFNames=Dpse_GA10064 {ECO:0000313|EMBL:EAL31307.3}, GA10064 GN {ECO:0000313|FlyBase:FBgn0070123}; OS Drosophila pseudoobscura pseudoobscura (Fruit fly). OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; OC Pterygota; Neoptera; Holometabola; Diptera; Brachycera; Muscomorpha; OC Ephydroidea; Drosophilidae; Drosophila; Sophophora. OX NCBI_TaxID=46245 {ECO:0000313|EMBL:EAL31307.3, ECO:0000313|Proteomes:UP000001819}; RN [1] {ECO:0000313|EMBL:EAL31307.3, ECO:0000313|Proteomes:UP000001819} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=MV2-25 / Tucson 14011-0121.94 RC {ECO:0000313|Proteomes:UP000001819}; RX PubMed=15632085; DOI=10.1101/gr.3059305; RA Richards S., Liu Y., Bettencourt B.R., Hradecky P., Letovsky S., RA Nielsen R., Thornton K., Hubisz M.J., Chen R., Meisel R.P., RA Couronne O., Hua S., Smith M.A., Zhang P., Liu J., Bussemaker H.J., RA van Batenburg M.F., Howells S.L., Scherer S.E., Sodergren E., RA Matthews B.B., Crosby M.A., Schroeder A.J., Ortiz-Barrientos D., RA Rives C.M., Metzker M.L., Muzny D.M., Scott G., Steffen D., RA Wheeler D.A., Worley K.C., Havlak P., Durbin K.J., Egan A., Gill R., RA Hume J., Morgan M.B., Miner G., Hamilton C., Huang Y., Waldron L., RA Verduzco D., Clerc-Blankenburg K.P., Dubchak I., Noor M.A., RA Anderson W., White K.P., Clark A.G., Schaeffer S.W., Gelbart W., RA Weinstock G.M., Gibbs R.A.; RT "Comparative genome sequencing of Drosophila pseudoobscura: RT chromosomal, gene, and cis-element evolution."; RL Genome Res. 15:1-18(2005). RN [2] {ECO:0000313|EMBL:EAL31307.3, ECO:0000313|Proteomes:UP000001819} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=MV2-25 / Tucson 14011-0121.94 RC {ECO:0000313|Proteomes:UP000001819}; RX PubMed=17994087; DOI=10.1038/nature06341; RG Drosophila 12 Genomes Consortium; RA Clark A.G., Eisen M.B., Smith D.R., Bergman C.M., Oliver B., RA Markow T.A., Kaufman T.C., Kellis M., Gelbart W., Iyer V.N., RA Pollard D.A., Sackton T.B., Larracuente A.M., Singh N.D., Abad J.P., RA Abt D.N., Adryan B., Aguade M., Akashi H., Anderson W.W., RA Aquadro C.F., Ardell D.H., Arguello R., Artieri C.G., Barbash D.A., RA Barker D., Barsanti P., Batterham P., Batzoglou S., Begun D., RA Bhutkar A., Blanco E., Bosak S.A., Bradley R.K., Brand A.D., RA Brent M.R., Brooks A.N., Brown R.H., Butlin R.K., Caggese C., RA Calvi B.R., Bernardo de Carvalho A., Caspi A., Castrezana S., RA Celniker S.E., Chang J.L., Chapple C., Chatterji S., Chinwalla A., RA Civetta A., Clifton S.W., Comeron J.M., Costello J.C., Coyne J.A., RA Daub J., David R.G., Delcher A.L., Delehaunty K., Do C.B., Ebling H., RA Edwards K., Eickbush T., Evans J.D., Filipski A., Findeiss S., RA Freyhult E., Fulton L., Fulton R., Garcia A.C., Gardiner A., RA Garfield D.A., Garvin B.E., Gibson G., Gilbert D., Gnerre S., RA Godfrey J., Good R., Gotea V., Gravely B., Greenberg A.J., RA Griffiths-Jones S., Gross S., Guigo R., Gustafson E.A., Haerty W., RA Hahn M.W., Halligan D.L., Halpern A.L., Halter G.M., Han M.V., RA Heger A., Hillier L., Hinrichs A.S., Holmes I., Hoskins R.A., RA Hubisz M.J., Hultmark D., Huntley M.A., Jaffe D.B., Jagadeeshan S., RA Jeck W.R., Johnson J., Jones C.D., Jordan W.C., Karpen G.H., RA Kataoka E., Keightley P.D., Kheradpour P., Kirkness E.F., RA Koerich L.B., Kristiansen K., Kudrna D., Kulathinal R.J., Kumar S., RA Kwok R., Lander E., Langley C.H., Lapoint R., Lazzaro B.P., Lee S.J., RA Levesque L., Li R., Lin C.F., Lin M.F., Lindblad-Toh K., Llopart A., RA Long M., Low L., Lozovsky E., Lu J., Luo M., Machado C.A., RA Makalowski W., Marzo M., Matsuda M., Matzkin L., McAllister B., RA McBride C.S., McKernan B., McKernan K., Mendez-Lago M., Minx P., RA Mollenhauer M.U., Montooth K., Mount S.M., Mu X., Myers E., Negre B., RA Newfeld S., Nielsen R., Noor M.A., O'Grady P., Pachter L., RA Papaceit M., Parisi M.J., Parisi M., Parts L., Pedersen J.S., RA Pesole G., Phillippy A.M., Ponting C.P., Pop M., Porcelli D., RA Powell J.R., Prohaska S., Pruitt K., Puig M., Quesneville H., RA Ram K.R., Rand D., Rasmussen M.D., Reed L.K., Reenan R., Reily A., RA Remington K.A., Rieger T.T., Ritchie M.G., Robin C., Rogers Y.H., RA Rohde C., Rozas J., Rubenfield M.J., Ruiz A., Russo S., Salzberg S.L., RA Sanchez-Gracia A., Saranga D.J., Sato H., Schaeffer S.W., Schatz M.C., RA Schlenke T., Schwartz R., Segarra C., Singh R.S., Sirot L., Sirota M., RA Sisneros N.B., Smith C.D., Smith T.F., Spieth J., Stage D.E., RA Stark A., Stephan W., Strausberg R.L., Strempel S., Sturgill D., RA Sutton G., Sutton G.G., Tao W., Teichmann S., Tobari Y.N., RA Tomimura Y., Tsolas J.M., Valente V.L., Venter E., Venter J.C., RA Vicario S., Vieira F.G., Vilella A.J., Villasante A., Walenz B., RA Wang J., Wasserman M., Watts T., Wilson D., Wilson R.K., Wing R.A., RA Wolfner M.F., Wong A., Wong G.K., Wu C.I., Wu G., Yamamoto D., RA Yang H.P., Yang S.P., Yorke J.A., Yoshida K., Zdobnov E., Zhang P., RA Zhang Y., Zimin A.V., Baldwin J., Abdouelleil A., Abdulkadir J., RA Abebe A., Abera B., Abreu J., Acer S.C., Aftuck L., Alexander A., RA An P., Anderson E., Anderson S., Arachi H., Azer M., Bachantsang P., RA Barry A., Bayul T., Berlin A., Bessette D., Bloom T., Blye J., RA Boguslavskiy L., Bonnet C., Boukhgalter B., Bourzgui I., Brown A., RA Cahill P., Channer S., Cheshatsang Y., Chuda L., Citroen M., RA Collymore A., Cooke P., Costello M., D'Aco K., Daza R., De Haan G., RA DeGray S., DeMaso C., Dhargay N., Dooley K., Dooley E., Doricent M., RA Dorje P., Dorjee K., Dupes A., Elong R., Falk J., Farina A., Faro S., RA Ferguson D., Fisher S., Foley C.D., Franke A., Friedrich D., RA Gadbois L., Gearin G., Gearin C.R., Giannoukos G., Goode T., RA Graham J., Grandbois E., Grewal S., Gyaltsen K., Hafez N., Hagos B., RA Hall J., Henson C., Hollinger A., Honan T., Huard M.D., Hughes L., RA Hurhula B., Husby M.E., Kamat A., Kanga B., Kashin S., Khazanovich D., RA Kisner P., Lance K., Lara M., Lee W., Lennon N., Letendre F., RA LeVine R., Lipovsky A., Liu X., Liu J., Liu S., Lokyitsang T., RA Lokyitsang Y., Lubonja R., Lui A., MacDonald P., Magnisalis V., RA Maru K., Matthews C., McCusker W., McDonough S., Mehta T., Meldrim J., RA Meneus L., Mihai O., Mihalev A., Mihova T., Mittelman R., Mlenga V., RA Montmayeur A., Mulrain L., Navidi A., Naylor J., Negash T., Nguyen T., RA Nguyen N., Nicol R., Norbu C., Norbu N., Novod N., O'Neill B., RA Osman S., Markiewicz E., Oyono O.L., Patti C., Phunkhang P., RA Pierre F., Priest M., Raghuraman S., Rege F., Reyes R., Rise C., RA Rogov P., Ross K., Ryan E., Settipalli S., Shea T., Sherpa N., Shi L., RA Shih D., Sparrow T., Spaulding J., Stalker J., Stange-Thomann N., RA Stavropoulos S., Stone C., Strader C., Tesfaye S., Thomson T., RA Thoulutsang Y., Thoulutsang D., Topham K., Topping I., Tsamla T., RA Vassiliev H., Vo A., Wangchuk T., Wangdi T., Weiand M., Wilkinson J., RA Wilson A., Yadav S., Young G., Yu Q., Zembek L., Zhong D., Zimmer A., RA Zwirko Z., Jaffe D.B., Alvarez P., Brockman W., Butler J., Chin C., RA Gnerre S., Grabherr M., Kleber M., Mauceli E., MacCallum I.; RT "Evolution of genes and genomes on the Drosophila phylogeny."; RL Nature 450:203-218(2007). CC -!- COFACTOR: CC Name=Zn(2+); Xref=ChEBI:CHEBI:29105; CC Evidence={ECO:0000256|RuleBase:RU364040}; CC Note=Binds 1 zinc ion per subunit. CC {ECO:0000256|RuleBase:RU364040}; CC -!- SIMILARITY: Belongs to the peptidase M1 family. CC {ECO:0000256|RuleBase:RU364040}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; CH379067; EAL31307.3; -; Genomic_DNA. DR RefSeq; XP_001354254.3; XM_001354218.3. DR RefSeq; XP_001354254.3; XM_001354218.3. DR RefSeq; XP_001354254.3; XM_001354218.3. DR MEROPS; M01.A24; -. DR EnsemblMetazoa; FBtr0279501; FBpp0277939; FBgn0070123. DR GeneID; 4814127; -. DR KEGG; dpo:Dpse_GA10064; -. DR FlyBase; FBgn0070123; Dpse\GA10064. DR InParanoid; Q29FE8; -. DR KO; K08776; -. DR Proteomes; UP000001819; Partially assembled WGS sequence. DR GO; GO:0008237; F:metallopeptidase activity; IEA:InterPro. DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro. DR CDD; cd09601; M1_APN_2; 1. DR InterPro; IPR024571; ERAP1-like_C_dom. DR InterPro; IPR034016; M1_APN-typ. DR InterPro; IPR001930; Peptidase_M1. DR InterPro; IPR014782; Peptidase_M1_N. DR PANTHER; PTHR11533; PTHR11533; 1. DR Pfam; PF11838; ERAP1_C; 1. DR Pfam; PF01433; Peptidase_M1; 1. DR PRINTS; PR00756; ALADIPTASE. PE 3: Inferred from homology; KW Aminopeptidase {ECO:0000256|RuleBase:RU364040}; KW Complete proteome {ECO:0000313|Proteomes:UP000001819}; KW Hydrolase {ECO:0000256|RuleBase:RU364040}; KW Metal-binding {ECO:0000256|RuleBase:RU364040}; KW Metalloprotease {ECO:0000256|RuleBase:RU364040}; KW Protease {ECO:0000256|RuleBase:RU364040}; KW Reference proteome {ECO:0000313|Proteomes:UP000001819}; KW Zinc {ECO:0000256|RuleBase:RU364040}. FT DOMAIN 197 583 Peptidase_M1. {ECO:0000259|Pfam:PF01433}. FT DOMAIN 720 1033 ERAP1_C. {ECO:0000259|Pfam:PF11838}. SQ SEQUENCE 1053 AA; 120070 MW; AE77BBC7502EB4CD CRC64; MYKNALRGGI RTAKQAWRLK NATRPIQSCY PATETQPQLL NTSENNSRKS TRSQNTSPSI FNNQKNCNVA NHYRLFANVS PSTLDKHSNA HLRRIETAHL NELLSSKQFV KVQKQFYRDY SSVSLGAPLK SSDAPLLGDL CNQYRAILAY TSADVVPGQK QGQPQHQQIR GAHKQQETRM QQQEEVGGMA QKLEFKRLPT NVVPKHYELL LQPDLEAFTF KGKTIVQVQV KKPTKQIVLN ALDIIIEEAQ LEFECTKMKA DRIVYSTDAE TATLEFEKVI PAETAGVLQM SFTGELNDKM KGFYRSKYFS ASGEERYAGV TQFEATDARR CFPCWDEPAI KATFDITLVV PKNRVALSNM PVKKEDDLEG GLRRVRFDRT PIMSTYLVAC VVGEYDFVEG KSEDGIIVRV FTPVGKREQG QFALDVATKV LPFYKDYFNI AYPLPKMDLI AISDFSAGAM ENWGLVTYRE TFVLVDPKNT SLMRKQSIAL TVGHEIAHQW FGNLVTMEWW THLWLNEGYA SFVEFLCVHH LFPEYDIWTQ FVTDMYTRAL ELDSLKNSHP IEVPVGHPSE IDEIFDEISY NKGASVIRML HDYIGEDDFR KGMNIYLTRH QYGNTSTEDL WTALQEASSK NVAEVMSSWT QYKGFPVVSV ESEQKGKTQR ILRLSQRKFT ADGSQADGDC LWVVPISVST SRDPTAIAKT FLLDKPSMEV VLDGVTDSDW IKINPGTVGY YRTRYSKEML EQLMPAVKNM ELPPLDRLGL IDDMFAMVQA GHASTADVLA LVDGYRNETN YTVWTAITNS LTNLHVLISH TDLMEDFHRF GRNLYEPVAQ RLGWEPREGE NHLDTLLRSL VLTRLVSFRS NDVIEVARQR FRSHINGTQP LPADLRTTCY KAALQDGNEQ IFEEMLALYR TTDLHEEQDR ISRALGCSTD AKLLRRVIDF AMSGEVRAQD SVFVIVAVAI NPKGRDMAWE FFKSSNKQLL ERYQGGFLLT RLIKYLIENY ASEEKAKEVE EFFRVTQIPG CERTVSQAVE TIRLNAAWLE RDREKLSTYL KSV //