ID PF2R_SHEEP Reviewed; 362 AA. AC Q28905; DT 01-NOV-1997, integrated into UniProtKB/Swiss-Prot. DT 01-NOV-1996, sequence version 1. DT 19-FEB-2014, entry version 87. DE RecName: Full=Prostaglandin F2-alpha receptor; DE Short=PGF receptor; DE Short=PGF2-alpha receptor; DE AltName: Full=Prostanoid FP receptor; GN Name=PTGFR; OS Ovis aries (Sheep). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Ruminantia; OC Pecora; Bovidae; Caprinae; Ovis. OX NCBI_TaxID=9940; RN [1] RP NUCLEOTIDE SEQUENCE [MRNA]. RC STRAIN=Western range; TISSUE=Corpus luteum; RX PubMed=7628379; DOI=10.1210/en.136.8.3430; RA Graves P.E., Pierce K.L., Bailey T.J., Rueda B.R., Gil D.W., RA Woodward D.F., Yool A.J., Hoyer P.B., Regan J.W.; RT "Cloning of a receptor for prostaglandin F2 alpha from the ovine RT corpus luteum."; RL Endocrinology 136:3430-3436(1995). RN [2] RP NUCLEOTIDE SEQUENCE [MRNA], AND ALTERNATIVE SPLICING. RC TISSUE=Corpus luteum; RX PubMed=8995377; DOI=10.1074/jbc.272.2.883; RA Pierce K.L., Bailey T.J., Hoyer P.B., Gil D.W., Woodward D.F., RA Regan J.W.; RT "Cloning of a carboxyl-terminal isoform of the prostanoid FP RT receptor."; RL J. Biol. Chem. 272:883-887(1997). CC -!- FUNCTION: Receptor for prostaglandin F2-alpha (PGF2-alpha). The CC activity of this receptor is mediated by G proteins which activate CC a phosphatidylinositol-calcium second messenger system. Initiates CC luteolysis in the corpus luteum. CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein. CC -!- ALTERNATIVE PRODUCTS: CC Event=Alternative splicing; Named isoforms=2; CC Comment=Isoform FP-A and isoform FP-B have identical ligand CC binding properties but different G protein coupling properties; CC Name=FP-A; CC IsoId=Q28905-1; Sequence=Displayed; CC Name=FP-B; CC IsoId=Q28905-2; Sequence=VSP_001951; CC Note=Shows agonist-independent constitutive activity, but is CC still responsive to agonist; CC -!- DEVELOPMENTAL STAGE: Expression is high in the midluteal phase CC corpus luteum and decreases during luteolysis. CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; U73798; AAB51070.1; -; mRNA. DR RefSeq; NP_001009789.1; NM_001009789.2. DR UniGene; Oar.531; -. DR ProteinModelPortal; Q28905; -. DR BindingDB; Q28905; -. DR ChEMBL; CHEMBL1909491; -. DR GeneID; 443366; -. DR CTD; 5737; -. DR HOVERGEN; HBG003621; -. DR GO; GO:0005737; C:cytoplasm; IEA:Ensembl. DR GO; GO:0005576; C:extracellular region; IEA:Ensembl. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell. DR GO; GO:0004958; F:prostaglandin F receptor activity; IEA:InterPro. DR GO; GO:0043066; P:negative regulation of apoptotic process; IEA:Ensembl. DR GO; GO:0032496; P:response to lipopolysaccharide; IEA:Ensembl. DR InterPro; IPR000276; GPCR_Rhodpsn. DR InterPro; IPR017452; GPCR_Rhodpsn_7TM. DR InterPro; IPR000141; PglndnF_rcpt. DR InterPro; IPR008365; Prostanoid_rcpt. DR InterPro; IPR001244; Prostglndn_DP_rcpt. DR PANTHER; PTHR11866; PTHR11866; 1. DR PANTHER; PTHR11866:SF4; PTHR11866:SF4; 1. DR Pfam; PF00001; 7tm_1; 1. DR PRINTS; PR00428; PROSTAGLNDNR. DR PRINTS; PR01788; PROSTANOIDR. DR PRINTS; PR00855; PRSTNOIDFPR. DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. PE 2: Evidence at transcript level; KW Alternative splicing; Cell membrane; Complete proteome; KW Disulfide bond; G-protein coupled receptor; Glycoprotein; Membrane; KW Receptor; Transducer; Transmembrane; Transmembrane helix. FT CHAIN 1 362 Prostaglandin F2-alpha receptor. FT /FTId=PRO_0000070073. FT TOPO_DOM 1 31 Extracellular (Potential). FT TRANSMEM 32 54 Helical; Name=1; (Potential). FT TOPO_DOM 55 69 Cytoplasmic (Potential). FT TRANSMEM 70 90 Helical; Name=2; (Potential). FT TOPO_DOM 91 109 Extracellular (Potential). FT TRANSMEM 110 131 Helical; Name=3; (Potential). FT TOPO_DOM 132 152 Cytoplasmic (Potential). FT TRANSMEM 153 175 Helical; Name=4; (Potential). FT TOPO_DOM 176 198 Extracellular (Potential). FT TRANSMEM 199 224 Helical; Name=5; (Potential). FT TOPO_DOM 225 250 Cytoplasmic (Potential). FT TRANSMEM 251 267 Helical; Name=6; (Potential). FT TOPO_DOM 268 285 Extracellular (Potential). FT TRANSMEM 286 307 Helical; Name=7; (Potential). FT TOPO_DOM 308 362 Cytoplasmic (Potential). FT CARBOHYD 4 4 N-linked (GlcNAc...) (Potential). FT CARBOHYD 19 19 N-linked (GlcNAc...) (Potential). FT DISULFID 108 186 By similarity. FT VAR_SEQ 317 362 VCTRRCCGVHVISLHVWELSSIKNSLKVAAISDLPVTEKVT FT QQTST -> I (in isoform FP-B). FT /FTId=VSP_001951. FT CONFLICT 6 6 S -> C (in Ref. 2; AAB51070). SQ SEQUENCE 362 AA; 40985 MW; 83604FC18EADF583 CRC64; MSTNNSVQPV SPASELLSNT TCQLEEDLSI SFSIIFMTVG ILSNSLAIAI LMKAYQRFRQ KYKSSFLLLA SALVITDFFG HLINGTIAVF VYASDKDWIY FDKSNILCSI FGICMVFSGL CPLFLGSLMA IERCIGVTKP IFHSTKITTK HVKMMLSGVC FFAVFVALLP ILGHRDYKIQ ASRTWCFYKT DQIKDWEDRF YLLLFAFLGL LALGISFVCN AITGISLLKV KFRSQQHRQG RSHHFEMVIQ LLGIMCVSCI CWSPFLVTMA SIGMNIQDFK DSCERTLFTL RMATWNQILD PWVYILLRKA VLRNLYVCTR RCCGVHVISL HVWELSSIKN SLKVAAISDL PVTEKVTQQT ST //