ID PF2R_SHEEP STANDARD; PRT; 362 AA. AC Q28905; DT 01-NOV-1997 (REL. 35, CREATED) DT 01-NOV-1997 (REL. 35, LAST SEQUENCE UPDATE) DT 15-JUL-1998 (REL. 36, LAST ANNOTATION UPDATE) DE PROSTAGLANDIN F2-ALPHA RECEPTOR (PROSTANOID FP RECEPTOR) (PGF DE RECEPTOR) (PGF2 ALPHA RECEPTOR). GN PTGFR. OS OVIS ARIES (SHEEP). OC EUKARYOTA; METAZOA; CHORDATA; VERTEBRATA; TETRAPODA; MAMMALIA; OC EUTHERIA; ARTIODACTYLA. RN [1] RP SEQUENCE FROM N.A. RC STRAIN=WESTERN RANGE; TISSUE=CORPUS LUTEUM; RX MEDLINE; 95354592. RA GRAVES P.E., PIERCE K.L., BAILEY T.J., RUEDA B.R., GIL D.W., RA WOODWARD D.F., YOOL A.J., HOYER P.B., REGAN J.W.; RL ENDOCRINOLOGY 136:3430-3436(1995). RN [2] RP SEQUENCE FROM N.A., AND ALTERNATIVE SPLICING. RC TISSUE=CORPUS LUTEUM; RX MEDLINE; 97150841. RA PIERCE K.L., BAILEY T.J., HOYER P.B., GIL D.W., WOODWARD D.F., RA REGAN J.W.; RL J. BIOL. CHEM. 272:883-887(1997). CC -!- FUNCTION: RECEPTOR FOR PROSTAGLANDIN F2-ALPHA (PGF2-ALPHA). THE CC ACTIVITY OF THIS RECEPTOR IS MEDIATED BY G PROTEINS WHICH ACTIVATE CC A PHOSPHATIDYLINOSITOL-CALCIUM SECOND MESSENGER SYSTEM. INITIATES CC LUTEOLYSIS IN THE CORPUS LUTEUM. CC -!- SUBCELLULAR LOCATION: INTEGRAL MEMBRANE PROTEIN. CC -!- DEVELOPMENTAL STAGE: EXPRESSION IS HIGH IN THE MIDLUTEAL PHASE CC CORPUS LUTEUM AND DECREASES DURING LUTEOLYSIS. CC -!- ALTERNATIVE PRODUCTS: TWO FORMS THAT DIFFERS AT THE C-TERMINUS ARE CC PRODUCED BY ALTERNATIVE SPLICING. FP-A RECEPTOR (SHOWN HERE) AND CC FP-B RECEPTOR HAVE IDENTICAL LIGAND BINDING PROPERTIES BUT CC DIFFERENT G PROTEIN COUPLING PROPERTIES. FP-B SHOWS AGONIST- CC INDEPENDENT CONSTITUTIVE ACTIVITY, BUT IS STILL RESPONSIVE TO CC AGONIST. CC -!- SIMILARITY: BELONGS TO FAMILY 1 OF G-PROTEIN COUPLED RECEPTORS. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; U73798; G1914835; -. DR GCRDB; GCR_1579; -. DR PROSITE; PS00237; G_PROTEIN_RECEPTOR; 1. KW G-PROTEIN COUPLED RECEPTOR; TRANSMEMBRANE; GLYCOPROTEIN; KW ALTERNATIVE SPLICING. FT DOMAIN 1 31 EXTRACELLULAR (POTENTIAL). FT TRANSMEM 32 54 1 (POTENTIAL). FT DOMAIN 56 69 CYTOPLASMIC (POTENTIAL). FT TRANSMEM 70 90 2 (POTENTIAL). FT DOMAIN 91 109 EXTRACELLULAR (POTENTIAL). FT TRANSMEM 110 131 3 (POTENTIAL). FT DOMAIN 132 152 CYTOPLASMIC (POTENTIAL). FT TRANSMEM 153 175 4 (POTENTIAL). FT DOMAIN 176 198 EXTRACELLULAR (POTENTIAL). FT TRANSMEM 199 224 5 (POTENTIAL). FT DOMAIN 225 250 CYTOPLASMIC (POTENTIAL). FT TRANSMEM 251 267 6 (POTENTIAL). FT DOMAIN 268 285 EXTRACELLULAR (POTENTIAL). FT TRANSMEM 286 307 7 (POTENTIAL). FT DOMAIN 308 362 CYTOPLASMIC (POTENTIAL). FT CARBOHYD 4 4 POTENTIAL. FT CARBOHYD 19 19 POTENTIAL. FT DISULFID 108 186 BY SIMILARITY. FT VARSPLIC 317 362 VCTRRCCGVHVISLHVWELSSIKNSLKVAAISDLPVTEKVT FT QQTST -> I (IN FP-B). FT CONFLICT 6 6 S -> C (IN REF. 2). SQ SEQUENCE 362 AA; 40984 MW; A34A2A80 CRC32; MSTNNSVQPV SPASELLSNT TCQLEEDLSI SFSIIFMTVG ILSNSLAIAI LMKAYQRFRQ KYKSSFLLLA SALVITDFFG HLINGTIAVF VYASDKDWIY FDKSNILCSI FGICMVFSGL CPLFLGSLMA IERCIGVTKP IFHSTKITTK HVKMMLSGVC FFAVFVALLP ILGHRDYKIQ ASRTWCFYKT DQIKDWEDRF YLLLFAFLGL LALGISFVCN AITGISLLKV KFRSQQHRQG RSHHFEMVIQ LLGIMCVSCI CWSPFLVTMA SIGMNIQDFK DSCERTLFTL RMATWNQILD PWVYILLRKA VLRNLYVCTR RCCGVHVISL HVWELSSIKN SLKVAAISDL PVTEKVTQQT ST //