ID ALL2_BOVIN STANDARD; PRT; 172 AA. AC Q28133; DT 01-NOV-1997 (Rel. 35, Created) DT 01-NOV-1997 (Rel. 35, Last sequence update) DT 30-MAY-2000 (Rel. 39, Last annotation update) DE ALLERGEN BOS D 2 PRECURSOR (DANDER MAJOR ALLERGEN BDA20) (DERMAL DE ALLERGEN BDA20). OS Bos taurus (Bovine). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Cetartiodactyla; Ruminantia; Pecora; Bovoidea; OC Bovidae; Bovinae; Bos. OX NCBI_TaxID=9913; RN [1] RP SEQUENCE FROM N.A. RC TISSUE=Skin; RX MEDLINE=96243710; PubMed=8648026; RA Maentyjaervi R., Parkkinen S., Rytkoenen M., Pentikaeinen J., RA Pelkonen J., Rautiainen J., Virtanen T.; RT "Complementary DNA cloning of the predominant allergen of bovine RT dander: a new member in the lipocalin family."; RL J. Allergy Clin. Immunol. 97:1297-1303(1996). RN [2] RP 3D-STRUCTURE MODELING. RX MEDLINE=99068569; PubMed=9853680; RA Santa H., Saarela J.T., Laatikainen R., Rautiainen J., Virtanen T., RA Rytkonen M., Maentyjaervi R.; RT "A bovine dander allergen, comparative modeling, and similarities and RT differences in folding with related proteins."; RL J. Protein Chem. 17:657-662(1998). RN [3] RP X-RAY CRYSTALLOGRAPHY (1.8 ANGSTROMS). RX MEDLINE=99107890; PubMed=9891000; RA Rouvinen J., Rautiainen J., Virtanen T., Zeiler T., Kauppinen J., RA Taivainen A., Maentyjaervi R.; RT "Probing the molecular basis of allergy. three-dimensional structure RT of the bovine lipocalin allergen bos d 2."; RL J. Biol. Chem. 274:2337-2343(1999). RN [4] RP CHARACTERIZATION, AND CRYSTALLIZATION. RX MEDLINE=98321199; PubMed=9647765; RA Rautiainen J., Auriola S., Rouvinen J., Kauppinen J., Zeiler T., RA Novikov D., Virtanen T., Maentyjaervi R.A.; RT "Molecular and crystal properties of Bos d 2, an allergenic protein of RT the lipocalin family."; RL Biochem. Biophys. Res. Commun. 247:746-750(1998). RN [5] RP TISSUE SPECIFICITY. RX MEDLINE=98184363; PubMed=9525451; RA Rautiainen J., Rytkoenen M., Syrjaenen K., Pentikaeinen J., Zeiler T., RA Virtanen T., Maentyjaervi R.; RT "Tissue localization of bovine dander allergen Bos d 2."; RL J. Allergy Clin. Immunol. 101:349-353(1998). CC -!- FUNCTION: PROBABLE PHEROMONE CARRIER. CC -!- SUBCELLULAR LOCATION: SECRETED. CC -!- TISSUE SPECIFICITY: FOUND EXCLUSIVELY IN SKIN. PRODUCED IN SWEAT CC GLANDS AND TRANSPORTED TO THE SKIN SURFACE. CC -!- MISCELLANEOUS: PREDOMINANT ALLERGEN OF BOVINE DANDER. CC -!- SIMILARITY: BELONGS TO THE LIPOCALIN FAMILY. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; L42867; AAB08720.1; -. DR PDB; 1BJ7; 11-MAY-99. DR InterPro; IPR000566; Lipocln_cytFABP. DR Pfam; PF00061; lipocalin; 1. DR PROSITE; PS00213; LIPOCALIN; FALSE_NEG. KW Transport; Lipocalin; Signal; Allergen; 3D-structure. FT SIGNAL 1 16 FT CHAIN 17 172 ALLERGEN BOS D 2. FT MOD_RES 17 17 PYRROLIDONE CARBOXYLIC ACID. FT DISULFID 60 64 FT DISULFID 79 170 SQ SEQUENCE 172 AA; 19560 MW; C50F66F1B3D98156 CRC64; MKAVFLTLLF GLVCTAQETP AEIDPSKIPG EWRIIYAAAD NKDKIVEGGP LRNYYRRIEC INDCESLSIT FYLKDQGTCL LLTEVAKRQE GYVYVLEFYG TNTLEVIHVS ENMLVTYVEN YDGERITKMT EGLAKGTSFT PEELEKYQQL NSERGVPNEN IENLIKTDNC PP //