ID ALL2_BOVIN STANDARD; PRT; 172 AA. AC Q28133; DT 01-NOV-1997, integrated into UniProtKB/Swiss-Prot. DT 01-NOV-1997, sequence version 1. DT 19-SEP-2006, entry version 45. DE Allergen Bos d 2 precursor (Dander major allergen BDA20) (Dermal DE allergen BDA20). OS Bos taurus (Bovine). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Ruminantia; OC Pecora; Bovidae; Bovinae; Bos. OX NCBI_TaxID=9913; RN [1] RP NUCLEOTIDE SEQUENCE [MRNA], AND ALLERGENICITY. RC TISSUE=Skin; RX MEDLINE=96243710; PubMed=8648026; RA Maentyjaervi R., Parkkinen S., Rytkoenen M., Pentikaeinen J., RA Pelkonen J., Rautiainen J., Virtanen T.; RT "Complementary DNA cloning of the predominant allergen of bovine RT dander: a new member in the lipocalin family."; RL J. Allergy Clin. Immunol. 97:1297-1303(1996). RN [2] RP 3D-STRUCTURE MODELING. RX MEDLINE=99068569; PubMed=9853680; RA Santa H., Saarela J.T., Laatikainen R., Rautiainen J., Virtanen T., RA Rytkonen M., Maentyjaervi R.; RT "A bovine dander allergen, comparative modeling, and similarities and RT differences in folding with related proteins."; RL J. Protein Chem. 17:657-662(1998). RN [3] RP X-RAY CRYSTALLOGRAPHY (1.8 ANGSTROMS). RX MEDLINE=99107890; PubMed=9891000; DOI=10.1074/jbc.274.4.2337; RA Rouvinen J., Rautiainen J., Virtanen T., Zeiler T., Kauppinen J., RA Taivainen A., Maentyjaervi R.; RT "Probing the molecular basis of allergy. three-dimensional structure RT of the bovine lipocalin allergen Bos d 2."; RL J. Biol. Chem. 274:2337-2343(1999). RN [4] RP CHARACTERIZATION, AND CRYSTALLIZATION. RX MEDLINE=98321199; PubMed=9647765; DOI=10.1006/bbrc.1998.8851; RA Rautiainen J., Auriola S., Rouvinen J., Kauppinen J., Zeiler T., RA Novikov D., Virtanen T., Maentyjaervi R.A.; RT "Molecular and crystal properties of Bos d 2, an allergenic protein of RT the lipocalin family."; RL Biochem. Biophys. Res. Commun. 247:746-750(1998). RN [5] RP TISSUE SPECIFICITY. RX MEDLINE=98184363; PubMed=9525451; RA Rautiainen J., Rytkoenen M., Syrjaenen K., Pentikaeinen J., Zeiler T., RA Virtanen T., Maentyjaervi R.; RT "Tissue localization of bovine dander allergen Bos d 2."; RL J. Allergy Clin. Immunol. 101:349-353(1998). CC -!- FUNCTION: Probable pheromone carrier. CC -!- SUBCELLULAR LOCATION: Secreted protein. CC -!- TISSUE SPECIFICITY: Found exclusively in skin. Produced in sweat CC glands and transported to the skin surface. CC -!- ALLERGEN: Causes an allergic reaction in human. Potent allergen of CC bovine dander. CC -!- SIMILARITY: Belongs to the lipocalin family. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; L42867; AAB08720.1; -; mRNA. DR UniGene; Bt.550; -. DR PDB; 1BJ7; X-ray; @=17-172. DR KEGG; bta:286791; -. DR InterPro; IPR012674; Calycin. DR InterPro; IPR011038; Calycin_like. DR InterPro; IPR002345; Lipocalin. DR InterPro; IPR000566; Lipocln_cytFABP. DR InterPro; IPR002448; Odour_bd. DR Pfam; PF00061; Lipocalin; 1. DR PRINTS; PR01173; ODORANTBNDNG. DR PROSITE; PS00213; LIPOCALIN; FALSE_NEG. KW 3D-structure; Allergen; Pyrrolidone carboxylic acid; Signal; KW Transport. FT SIGNAL 1 16 FT CHAIN 17 172 Allergen Bos d 2. FT /FTId=PRO_0000017983. FT MOD_RES 17 17 Pyrrolidone carboxylic acid. FT DISULFID 60 64 FT DISULFID 79 170 FT HELIX 25 27 FT STRAND 28 31 FT STRAND 33 41 FT HELIX 42 44 FT TURN 45 45 FT STRAND 46 46 FT TURN 47 48 FT TURN 50 51 FT STRAND 54 61 FT TURN 62 65 FT STRAND 66 75 FT TURN 76 77 FT STRAND 78 90 FT TURN 91 92 FT STRAND 93 109 FT STRAND 111 121 FT STRAND 123 124 FT STRAND 126 137 FT HELIX 141 153 FT TURN 154 155 FT HELIX 158 160 FT STRAND 161 163 FT HELIX 165 167 FT STRAND 170 170 SQ SEQUENCE 172 AA; 19560 MW; C50F66F1B3D98156 CRC64; MKAVFLTLLF GLVCTAQETP AEIDPSKIPG EWRIIYAAAD NKDKIVEGGP LRNYYRRIEC INDCESLSIT FYLKDQGTCL LLTEVAKRQE GYVYVLEFYG TNTLEVIHVS ENMLVTYVEN YDGERITKMT EGLAKGTSFT PEELEKYQQL NSERGVPNEN IENLIKTDNC PP //