ID ALL2_BOVIN STANDARD; PRT; 172 AA. AC Q28133; DT 01-NOV-1997 (Rel. 35, Created) DT 01-NOV-1997 (Rel. 35, Last sequence update) DT 15-JUL-1999 (Rel. 38, Last annotation update) DE ALLERGEN BOS D 2 PRECURSOR (DANDER MAJOR ALLERGEN BDA20) (DERMAL DE ALLERGEN BDA20). OS Bos taurus (Bovine). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Mammalia; OC Eutheria; Cetartiodactyla; Ruminantia; Pecora; Bovoidea; Bovidae; OC Bovinae; Bos. RN [1] RP SEQUENCE FROM N.A. RC TISSUE=SKIN; RA MAENTYJAERVI R., PARKKINEN S., RYTKOENEN M., PENTIKAEINEN J., RA PELKONEN J., RAUTIAINEN J., VIRTANEN T.; RL Submitted (JUL-1995) to the EMBL/GenBank/DDBJ databases. RN [2] RP 3D-STRUCTURE MODELING. RX MEDLINE; 99068569. RA SANTA H., SAARELA J.T., LAATIKAINEN R., RAUTIANEN J., VIRTANEN T., RA RYTKONEN M., MANTYJARVI R.; RT "A bovine dander allergen, comparative modeling, and similarities and RT differences in folding with related proteins."; RL J. Protein Chem. 17:657-662(1998). RN [3] RP X-RAY CRYSTALLOGRAPHY (1.8 ANGSTROMS). RX MEDLINE; 99107890. RA ROUVINEN J., RAUTIAINEN J., VIRTANEN T., ZEILER T., KAUPPINEN J., RA TAIVAINEN A., MANTYJARVI R.; RT "Probing the molecular basis of allergy. three-dimensional structure RT of the bovine lipocalin allergen bos d 2."; RL J. Biol. Chem. 274:2337-2343(1999). RN [4] RP CHARACTERIZATION, AND CRYSTALLIZATION. RX MEDLINE; 98321199. RA RAUTIAINEN J., AURIOLA S., ROUVINEN J., KAUPPINEN J., ZEILER T., RA NOVIKOV D., VIRTANEN T., MANTYJARVI R.A.; RT "Molecular and crystal properties of Bos d 2, an allergenic protein of RT the lipocalin family."; RL Biochem. Biophys. Res. Commun. 247:746-750(1998). RN [5] RP TISSUE SPECIFICITY. RX MEDLINE; 98184363. RA RAUTIAINEN J., RYTKONEN M., SYRJANEN K., PENTIKAINEN J., ZEILER T., RA VIRTANEN T., MANTYJARVI R.; RT "Tissue localization of bovine dander allergen Bos d 2."; RL J. Allergy Clin. Immunol. 101:349-353(1998). CC -!- FUNCTION: PROBABLE PHEROMONE CARRIER. CC -!- SUBCELLULAR LOCATION: SECRETED. CC -!- TISSUE SPECIFICITY: FOUND EXCLUSIVELY IN SKIN. PRODUCED IN SWEAT CC GLANDS AND TRANSPORTED TO THE SKIN SURFACE. CC -!- MISCELLANEOUS: PREDOMINANT ALLERGEN OF BOVINE DANDER. CC -!- SIMILARITY: BELONGS TO THE LIPOCALIN FAMILY. CC -------------------------------------------------------------------------- CC This SWISS-PROT entry is copyright. It is produced through a collaboration CC between the Swiss Institute of Bioinformatics and the EMBL outstation - CC the European Bioinformatics Institute. There are no restrictions on its CC use by non-profit institutions as long as its content is in no way CC modified and this statement is not removed. Usage by and for commercial CC entities requires a license agreement (See http://www.isb-sib.ch/announce/ CC or send an email to license@isb-sib.ch). CC -------------------------------------------------------------------------- CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; L42867; AAB08720.1; -. DR PDB; 1BJ7; PRELIMINARY. DR PFAM; PF00061; lipocalin; 1. DR PROSITE; PS00213; LIPOCALIN; FALSE_NEG. KW Transport; Lipocalin; Signal; Allergen; 3D-structure. FT SIGNAL 1 16 FT CHAIN 17 172 ALLERGEN BOS D 2. FT MOD_RES 17 17 PYRROLIDONE CARBOXYLIC ACID. FT DISULFID 60 64 FT DISULFID 79 170 SQ SEQUENCE 172 AA; 19560 MW; F001F3A4 CRC32; MKAVFLTLLF GLVCTAQETP AEIDPSKIPG EWRIIYAAAD NKDKIVEGGP LRNYYRRIEC INDCESLSIT FYLKDQGTCL LLTEVAKRQE GYVYVLEFYG TNTLEVIHVS ENMLVTYVEN YDGERITKMT EGLAKGTSFT PEELEKYQQL NSERGVPNEN IENLIKTDNC PP //