ID Q27SA1_PHRPL Unreviewed; 350 AA. AC Q27SA1; DT 04-APR-2006, integrated into UniProtKB/TrEMBL. DT 04-APR-2006, sequence version 1. DT 30-AUG-2017, entry version 55. DE SubName: Full=Recombination activiating gene-1 {ECO:0000313|EMBL:ABD49424.1}; DE Flags: Fragment; GN Name=RAG-1 {ECO:0000313|EMBL:ABD49424.1}; OS Phrynosoma platyrhinos (Desert horned lizard). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Lepidosauria; Squamata; Bifurcata; Unidentata; Episquamata; OC Toxicofera; Iguania; Iguanidae; Phrynosomatinae; Phrynosoma. OX NCBI_TaxID=52577 {ECO:0000313|EMBL:ABD49424.1}; RN [1] {ECO:0000313|EMBL:ABD49424.1} RP NUCLEOTIDE SEQUENCE. RX PubMed=16488160; DOI=10.1016/j.ympev.2005.12.016; RA Leache A.D., McGuire J.A.; RT "Phylogenetic relationships of horned lizards (Phrynosoma) based on RT nuclear and mitochondrial data: evidence for a misleading RT mitochondrial gene tree."; RL Mol. Phylogenet. Evol. 39:628-644(2006). CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|PROSITE- CC ProRule:PRU00820}. CC -!- DOMAIN: The NBD (nonamer binding) DNA-binding domain mediates the CC specific binding to the nonamer RSS motif by forming a tightly CC interwoven homodimer that binds and synapses 2 nonamer elements, CC with each NBD making contact with both DNA molecules. Each RSS is CC composed of well-conserved heptamer (consensus 5'-CACAGTG-3') and CC nonamer (consensus 5'-ACAAAAACC-3') sequences separated by a CC spacer of either 12 bp or 23 bp. {ECO:0000256|PROSITE- CC ProRule:PRU00820}. CC -!- SIMILARITY: Belongs to the RAG1 family. {ECO:0000256|PROSITE- CC ProRule:PRU00820}. CC -!- CAUTION: Lacks conserved residue(s) required for the propagation CC of feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00820}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; DQ385419; ABD49424.1; -; Genomic_DNA. DR ProteinModelPortal; Q27SA1; -. DR HOVERGEN; HBG100879; -. DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell. DR GO; GO:0004519; F:endonuclease activity; IEA:InterPro. DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW. DR GO; GO:0042803; F:protein homodimerization activity; IEA:UniProtKB-UniRule. DR GO; GO:0043565; F:sequence-specific DNA binding; IEA:UniProtKB-UniRule. DR GO; GO:0061630; F:ubiquitin protein ligase activity; IEA:InterPro. DR GO; GO:0033151; P:V(D)J recombination; IEA:UniProtKB-UniRule. DR Gene3D; 3.30.40.10; -; 3. DR InterPro; IPR024627; RAG1. DR InterPro; IPR019485; RAG1_Znf. DR InterPro; IPR023336; RAG_nonamer-bd_dom. DR InterPro; IPR013087; Znf_C2H2_type. DR InterPro; IPR018957; Znf_C3HC4_RING-type. DR InterPro; IPR001841; Znf_RING. DR InterPro; IPR013083; Znf_RING/FYVE/PHD. DR InterPro; IPR017907; Znf_RING_CS. DR PANTHER; PTHR11539; PTHR11539; 1. DR Pfam; PF00097; zf-C3HC4; 1. DR Pfam; PF10426; zf-RAG1; 1. DR SMART; SM00184; RING; 1. DR SUPFAM; SSF57667; SSF57667; 1. DR PROSITE; PS51487; NBD; 1. DR PROSITE; PS51765; ZF_RAG1; 1. DR PROSITE; PS00518; ZF_RING_1; 1. DR PROSITE; PS50089; ZF_RING_2; 1. PE 3: Inferred from homology; KW DNA recombination {ECO:0000256|PROSITE-ProRule:PRU00820}; KW DNA-binding {ECO:0000256|PROSITE-ProRule:PRU00820}; KW Metal-binding {ECO:0000256|SAAS:SAAS00547282}; KW Nucleus {ECO:0000256|PROSITE-ProRule:PRU00820}; KW Zinc {ECO:0000256|SAAS:SAAS00547042}; KW Zinc-finger {ECO:0000256|PROSITE-ProRule:PRU01101, KW ECO:0000256|SAAS:SAAS00546951}. FT DOMAIN 243 282 RING-type. {ECO:0000259|PROSITE:PS50089}. FT DOMAIN 304 333 RAG1-type. {ECO:0000259|PROSITE:PS51765}. FT DOMAIN 344 350 NBD (nonamer binding) DNA-binding. FT {ECO:0000259|PROSITE:PS51487}. FT NON_TER 1 1 {ECO:0000313|EMBL:ABD49424.1}. FT NON_TER 350 350 {ECO:0000313|EMBL:ABD49424.1}. SQ SEQUENCE 350 AA; 40020 MW; 2EBCF6641497ECAA CRC64; KGKVAATLDK VIEKEIETVS LISNTPFETD TELNKGMLTT DKSVLYMSQR EVETHQANLQ HLCRFCGGSF KTDPYKRSHP VHGPVDDETQ ALLRKKEKKA TSWPDLLAKV FKIDVKGDID TVHPTKFCHQ CWTVVQKKLN NFPCEMFFPR KSLVEWHPHS PSCDVCGASF HGMKRKRKVL NPQLNKKLRM VTRSARKKRQ IRNPKQVNQK SLVKMIASCK KIHLTTKILA VDYPADFVKS XSCQICEHIL ADPVETTCKH LFCRACILKC LKIMGSYCPA CRYPCFPTDL VGPVKSFLNI LNSLPVRCPV KDCQEEVCLV KYCHHLSSHK EVEDKEGYVY INKGGRPRQH //