ID   Q24JV8_DANRE            Unreviewed;       330 AA.
AC   Q24JV8;
DT   18-APR-2006, integrated into UniProtKB/TrEMBL.
DT   18-APR-2006, sequence version 1.
DT   02-DEC-2020, entry version 80.
DE   RecName: Full=Palmitoyltransferase {ECO:0000256|RuleBase:RU079119};
DE            EC=2.3.1.225 {ECO:0000256|RuleBase:RU079119};
DE   Flags: Fragment;
GN   Name=zdhhc15b {ECO:0000313|ZFIN:ZDB-GENE-061110-106};
GN   Synonyms=zgc:152683 {ECO:0000313|EMBL:AAI14274.1};
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Danio.
OX   NCBI_TaxID=7955 {ECO:0000313|EMBL:AAI14274.1};
RN   [1] {ECO:0000313|EMBL:AAI14274.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Whole {ECO:0000313|EMBL:AAI14274.1};
RG   NIH - Zebrafish Gene Collection (ZGC) project;
RL   Submitted (MAR-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=hexadecanoyl-CoA + L-cysteinyl-[protein] = CoA + S-
CC         hexadecanoyl-L-cysteinyl-[protein]; Xref=Rhea:RHEA:36683, Rhea:RHEA-
CC         COMP:10131, Rhea:RHEA-COMP:11032, ChEBI:CHEBI:29950,
CC         ChEBI:CHEBI:57287, ChEBI:CHEBI:57379, ChEBI:CHEBI:74151;
CC         EC=2.3.1.225; Evidence={ECO:0000256|RuleBase:RU079119};
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC       pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC   -!- DOMAIN: The DHHC domain is required for palmitoyltransferase activity.
CC       {ECO:0000256|RuleBase:RU079119}.
CC   -!- SIMILARITY: Belongs to the DHHC palmitoyltransferase family.
CC       {ECO:0000256|RuleBase:RU079119}.
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DR   EMBL; BC114273; AAI14274.1; -; mRNA.
DR   ZFIN; ZDB-GENE-061110-106; zdhhc15b.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0019706; F:protein-cysteine S-palmitoyltransferase activity; IEA:UniProtKB-EC.
DR   InterPro; IPR001594; Palmitoyltrfase_DHHC.
DR   Pfam; PF01529; DHHC; 1.
PE   2: Evidence at transcript level;
KW   Acyltransferase {ECO:0000256|RuleBase:RU079119};
KW   Membrane {ECO:0000256|RuleBase:RU079119};
KW   Transferase {ECO:0000256|RuleBase:RU079119};
KW   Transmembrane {ECO:0000256|RuleBase:RU079119};
KW   Transmembrane helix {ECO:0000256|RuleBase:RU079119}.
FT   TRANSMEM        12..29
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU079119"
FT   TRANSMEM        49..69
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU079119"
FT   TRANSMEM        165..189
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU079119"
FT   TRANSMEM        201..225
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU079119"
FT   DOMAIN          120..240
FT                   /note="DHHC"
FT                   /evidence="ECO:0000259|Pfam:PF01529"
FT   REGION          303..330
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   NON_TER         1
FT                   /evidence="ECO:0000313|EMBL:AAI14274.1"
SQ   SEQUENCE   330 AA;  38596 MW;  B9947F6A2988FCB5 CRC64;
     LSRALRCCQR IFSWIPVIII SSVVLWSYYA YVFELCFVTL SNNLERVTYL LIFHVCFIMF
     CWTYWKAIFT PPSTPTKKFH LSYTDKERYE MEERPEVQKQ ILVDIAKKLP IFTRAQSGAI
     RFCDRCQVIK PDRCHHCSVC ETCVLKMDHH CPWVNNCVGF SNYKFFLLFL SYSMIYCVFI
     ASTVFQYFLK FWVGDLPNGP AKFHVLFLLF VALMFFVSLM FLFGYHCWLV AKNRSTLEAF
     SPPVFQNGPD RNGFNVGLSK NLRQVFGEHK KLWFIPVFTS QGDGHYFPLR TLRESENPLL
     ANEEKWVEDG GSDEESADEN GSSLLIRTES
//