ID   Q22CX0_TETTS            Unreviewed;       718 AA.
AC   Q22CX0;
DT   18-APR-2006, integrated into UniProtKB/TrEMBL.
DT   16-APR-2014, sequence version 3.
DT   26-NOV-2014, entry version 71.
DE   RecName: Full=Palmitoyltransferase {ECO:0000256|RuleBase:RU079119};
DE            EC=2.3.1.225 {ECO:0000256|RuleBase:RU079119};
GN   ORFNames=TTHERM_01014660 {ECO:0000313|EMBL:EAR83149.3};
OS   Tetrahymena thermophila (strain SB210).
OC   Eukaryota; Alveolata; Ciliophora; Intramacronucleata;
OC   Oligohymenophorea; Hymenostomatida; Tetrahymenina; Tetrahymenidae;
OC   Tetrahymena.
OX   NCBI_TaxID=312017 {ECO:0000313|EMBL:EAR83149.3, ECO:0000313|Proteomes:UP000009168};
RN   [1] {ECO:0000313|Proteomes:UP000009168}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=SB210 {ECO:0000313|Proteomes:UP000009168};
RX   PubMed=16933976; DOI=10.1371/journal.pbio.0040286;
RA   Eisen J.A., Coyne R.S., Wu M., Wu D., Thiagarajan M., Wortman J.R.,
RA   Badger J.H., Ren Q., Amedeo P., Jones K.M., Tallon L.J., Delcher A.L.,
RA   Salzberg S.L., Silva J.C., Haas B.J., Majoros W.H., Farzad M.,
RA   Carlton J.M., Smith R.K. Jr., Garg J., Pearlman R.E., Karrer K.M.,
RA   Sun L., Manning G., Elde N.C., Turkewitz A.P., Asai D.J., Wilkes D.E.,
RA   Wang Y., Cai H., Collins K., Stewart B.A., Lee S.R., Wilamowska K.,
RA   Weinberg Z., Ruzzo W.L., Wloga D., Gaertig J., Frankel J., Tsao C.-C.,
RA   Gorovsky M.A., Keeling P.J., Waller R.F., Patron N.J., Cherry J.M.,
RA   Stover N.A., Krieger C.J., del Toro C., Ryder H.F., Williamson S.C.,
RA   Barbeau R.A., Hamilton E.P., Orias E.;
RT   "Macronuclear genome sequence of the ciliate Tetrahymena thermophila,
RT   a model eukaryote.";
RL   PLoS Biol. 4:1620-1642(2006).
CC   -!- CATALYTIC ACTIVITY: Palmitoyl-CoA + [protein]-L-cysteine =
CC       [protein]-S-palmitoyl-L-cysteine + CoA.
CC       {ECO:0000256|RuleBase:RU079119}.
CC   -!- DOMAIN: The DHHC domain is required for palmitoyltransferase
CC       activity. {ECO:0000256|RuleBase:RU079119}.
CC   -!- SIMILARITY: Belongs to the DHHC palmitoyltransferase family.
CC       {ECO:0000256|RuleBase:RU079119}.
CC   -!- SIMILARITY: Contains 1 DHHC-type zinc finger.
CC       {ECO:0000256|RuleBase:RU079119}.
CC   -!- SIMILARITY: Contains 4 ANK repeats.
CC       {ECO:0000256|RuleBase:RU079119}.
CC   -!- SIMILARITY: Contains DHHC-type zinc finger.
CC       {ECO:0000256|SAAS:SAAS00117289}.
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DR   EMBL; GG662521; EAR83149.3; -; Genomic_DNA.
DR   UniGene; Tth.4330; -.
DR   STRING; 5911.XP_001030812; -.
DR   EnsemblProtists; EAR83149; EAR83149; TTHERM_01014660.
DR   InParanoid; Q22CX0; -.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0000502; C:proteasome complex; IEA:UniProtKB-KW.
DR   GO; GO:0019706; F:protein-cysteine S-palmitoyltransferase activity; IEA:UniProtKB-EC.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   Gene3D; 1.25.40.20; -; 1.
DR   InterPro; IPR002110; Ankyrin_rpt.
DR   InterPro; IPR020683; Ankyrin_rpt-contain_dom.
DR   InterPro; IPR001594; Znf_DHHC_palmitoyltrfase.
DR   Pfam; PF12796; Ank_2; 1.
DR   Pfam; PF01529; zf-DHHC; 1.
DR   SMART; SM00248; ANK; 4.
DR   SUPFAM; SSF48403; SSF48403; 1.
DR   PROSITE; PS50297; ANK_REP_REGION; 1.
DR   PROSITE; PS50088; ANK_REPEAT; 1.
DR   PROSITE; PS50216; ZF_DHHC; 1.
PE   3: Inferred from homology;
KW   Acyltransferase {ECO:0000256|RuleBase:RU079119};
KW   ANK repeat {ECO:0000256|RuleBase:RU079119};
KW   Complete proteome {ECO:0000313|Proteomes:UP000009168};
KW   Membrane {ECO:0000256|RuleBase:RU079119};
KW   Metal-binding {ECO:0000256|RuleBase:RU079119,
KW   ECO:0000256|SAAS:SAAS00117307};
KW   Proteasome {ECO:0000313|EMBL:EAR83149.3};
KW   Reference proteome {ECO:0000313|Proteomes:UP000009168};
KW   Repeat {ECO:0000256|RuleBase:RU003536};
KW   Transferase {ECO:0000256|RuleBase:RU079119,
KW   ECO:0000256|SAAS:SAAS00117292};
KW   Transmembrane {ECO:0000256|RuleBase:RU079119};
KW   Transmembrane helix {ECO:0000256|RuleBase:RU079119};
KW   Zinc {ECO:0000256|RuleBase:RU079119, ECO:0000256|SAAS:SAAS00117282};
KW   Zinc-finger {ECO:0000256|RuleBase:RU079119,
KW   ECO:0000256|SAAS:SAAS00117305}.
SQ   SEQUENCE   718 AA;  84166 MW;  47AA0EBB3E536A85 CRC64;
     MIPEKNIKNS VECFSGMQLP KNYSEAIKFL KSLSNQQNVK LDYIVEILKV YKGINLNKFP
     KFNLLVQAVK DNNEFAFNLF LDYLQQADIP QEDKIEYINS NKALNCEEGY NALQYAVYYE
     FQDMALKLIE KGARYDTHIN EIGDKIIHSA ARGGSLKVIM KLQQLGVDIF EKTQSKGLNL
     STFEIACFEG NLHIMKYLLK MDEFENQKRI DINEQHPVSK ETPLHLGIRS KDYSVVKFLL
     IQGANKQLKN NENQTPLQFA IWRKEKIQKK LKEKRETVDQ YQIMEWESKI NHLDSLISLL
     GDIKFFNRLK LQTRVGPTKG MNKYSYILRI INILGFIGFI FILPYTDLFI GFIVFFYSIY
     LCSFYCLFCS YKSDPGYIKQ LGYESYQLDL NNNQPASQKD TFVNNFWLLL CKKEFEELCL
     ECCIIKPVRS KHCDFCNRCV AVMDHHCPFI KNCVGAKNHR YFFFMLVTQA LSQISILIAC
     IFALKELQQD DIEDEHSHQF IDSCPQLFNP IIAYISISIL IIQFIITCFP LFFIIIHQRT
     ILVNGLTSLE MRYKGKFDKQ KKEEIDENQP VTEVPNRTKS KQHPETRSNS TSQSTARLSH
     SNINDDQEDE QPEITEDQLE STDDQDTGSL YTALSAQQRD IFQNRNTNPS NKKWYENIKC
     MLFKNRKNKF YFADEELHRR IFQNQDQRFS LSCSQQFSEK DCLSKTESRN QLLMQYIK
//