ID   Q22CX0_TETTS            Unreviewed;       718 AA.
AC   Q22CX0;
DT   18-APR-2006, integrated into UniProtKB/TrEMBL.
DT   16-APR-2014, sequence version 3.
DT   07-OCT-2020, entry version 106.
DE   RecName: Full=Palmitoyltransferase {ECO:0000256|RuleBase:RU079119};
DE            EC=2.3.1.225 {ECO:0000256|RuleBase:RU079119};
GN   ORFNames=TTHERM_01014660 {ECO:0000313|EMBL:EAR83149.3};
OS   Tetrahymena thermophila (strain SB210).
OC   Eukaryota; Sar; Alveolata; Ciliophora; Intramacronucleata;
OC   Oligohymenophorea; Hymenostomatida; Tetrahymenina; Tetrahymenidae;
OC   Tetrahymena.
OX   NCBI_TaxID=312017 {ECO:0000313|EMBL:EAR83149.3, ECO:0000313|Proteomes:UP000009168};
RN   [1] {ECO:0000313|Proteomes:UP000009168}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=SB210 {ECO:0000313|Proteomes:UP000009168};
RX   PubMed=16933976; DOI=10.1371/journal.pbio.0040286;
RA   Eisen J.A., Coyne R.S., Wu M., Wu D., Thiagarajan M., Wortman J.R.,
RA   Badger J.H., Ren Q., Amedeo P., Jones K.M., Tallon L.J., Delcher A.L.,
RA   Salzberg S.L., Silva J.C., Haas B.J., Majoros W.H., Farzad M.,
RA   Carlton J.M., Smith R.K. Jr., Garg J., Pearlman R.E., Karrer K.M., Sun L.,
RA   Manning G., Elde N.C., Turkewitz A.P., Asai D.J., Wilkes D.E., Wang Y.,
RA   Cai H., Collins K., Stewart B.A., Lee S.R., Wilamowska K., Weinberg Z.,
RA   Ruzzo W.L., Wloga D., Gaertig J., Frankel J., Tsao C.-C., Gorovsky M.A.,
RA   Keeling P.J., Waller R.F., Patron N.J., Cherry J.M., Stover N.A.,
RA   Krieger C.J., del Toro C., Ryder H.F., Williamson S.C., Barbeau R.A.,
RA   Hamilton E.P., Orias E.;
RT   "Macronuclear genome sequence of the ciliate Tetrahymena thermophila, a
RT   model eukaryote.";
RL   PLoS Biol. 4:1620-1642(2006).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=hexadecanoyl-CoA + L-cysteinyl-[protein] = CoA + S-
CC         hexadecanoyl-L-cysteinyl-[protein]; Xref=Rhea:RHEA:36683, Rhea:RHEA-
CC         COMP:10131, Rhea:RHEA-COMP:11032, ChEBI:CHEBI:29950,
CC         ChEBI:CHEBI:57287, ChEBI:CHEBI:57379, ChEBI:CHEBI:74151;
CC         EC=2.3.1.225; Evidence={ECO:0000256|RuleBase:RU079119};
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC       pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC   -!- DOMAIN: The DHHC domain is required for palmitoyltransferase activity.
CC       {ECO:0000256|RuleBase:RU079119}.
CC   -!- SIMILARITY: Belongs to the DHHC palmitoyltransferase family.
CC       {ECO:0000256|RuleBase:RU079119}.
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DR   EMBL; GG662521; EAR83149.3; -; Genomic_DNA.
DR   RefSeq; XP_001030812.3; XM_001030812.3.
DR   STRING; 5911.EAR83149; -.
DR   EnsemblProtists; EAR83149; EAR83149; TTHERM_01014660.
DR   GeneID; 7830086; -.
DR   KEGG; tet:TTHERM_01014660; -.
DR   eggNOG; KOG0509; Eukaryota.
DR   eggNOG; KOG0726; Eukaryota.
DR   HOGENOM; CLU_267706_0_0_1; -.
DR   InParanoid; Q22CX0; -.
DR   KO; K20032; -.
DR   OrthoDB; 445686at2759; -.
DR   Proteomes; UP000009168; Unassembled WGS sequence.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0000502; C:proteasome complex; IEA:UniProtKB-KW.
DR   GO; GO:0019706; F:protein-cysteine S-palmitoyltransferase activity; IEA:UniProtKB-EC.
DR   Gene3D; 1.25.40.20; -; 1.
DR   InterPro; IPR002110; Ankyrin_rpt.
DR   InterPro; IPR020683; Ankyrin_rpt-contain_dom.
DR   InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR   InterPro; IPR001594; Palmitoyltrfase_DHHC.
DR   Pfam; PF12796; Ank_2; 1.
DR   Pfam; PF01529; DHHC; 1.
DR   SMART; SM00248; ANK; 4.
DR   SUPFAM; SSF48403; SSF48403; 1.
DR   PROSITE; PS50297; ANK_REP_REGION; 1.
DR   PROSITE; PS50088; ANK_REPEAT; 1.
PE   3: Inferred from homology;
KW   Acyltransferase {ECO:0000256|ARBA:ARBA00023315,
KW   ECO:0000256|RuleBase:RU079119};
KW   ANK repeat {ECO:0000256|PROSITE-ProRule:PRU00023};
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Membrane {ECO:0000256|RuleBase:RU079119};
KW   Proteasome {ECO:0000313|EMBL:EAR83149.3};
KW   Reference proteome {ECO:0000313|Proteomes:UP000009168};
KW   Transferase {ECO:0000256|RuleBase:RU079119};
KW   Transmembrane {ECO:0000256|RuleBase:RU079119};
KW   Transmembrane helix {ECO:0000256|RuleBase:RU079119}.
FT   TRANSMEM        326..343
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU079119"
FT   TRANSMEM        349..371
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU079119"
FT   TRANSMEM        461..484
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU079119"
FT   TRANSMEM        511..536
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU079119"
FT   DOMAIN          108..261
FT                   /note="ANK_REP_REGION"
FT                   /evidence="ECO:0000259|PROSITE:PS50297"
FT   REPEAT          219..251
FT                   /note="ANK"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT   REGION          559..626
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          264..284
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COMPBIAS        585..601
FT                   /note="Polar"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        608..623
FT                   /note="Acidic"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   718 AA;  84166 MW;  47AA0EBB3E536A85 CRC64;
     MIPEKNIKNS VECFSGMQLP KNYSEAIKFL KSLSNQQNVK LDYIVEILKV YKGINLNKFP
     KFNLLVQAVK DNNEFAFNLF LDYLQQADIP QEDKIEYINS NKALNCEEGY NALQYAVYYE
     FQDMALKLIE KGARYDTHIN EIGDKIIHSA ARGGSLKVIM KLQQLGVDIF EKTQSKGLNL
     STFEIACFEG NLHIMKYLLK MDEFENQKRI DINEQHPVSK ETPLHLGIRS KDYSVVKFLL
     IQGANKQLKN NENQTPLQFA IWRKEKIQKK LKEKRETVDQ YQIMEWESKI NHLDSLISLL
     GDIKFFNRLK LQTRVGPTKG MNKYSYILRI INILGFIGFI FILPYTDLFI GFIVFFYSIY
     LCSFYCLFCS YKSDPGYIKQ LGYESYQLDL NNNQPASQKD TFVNNFWLLL CKKEFEELCL
     ECCIIKPVRS KHCDFCNRCV AVMDHHCPFI KNCVGAKNHR YFFFMLVTQA LSQISILIAC
     IFALKELQQD DIEDEHSHQF IDSCPQLFNP IIAYISISIL IIQFIITCFP LFFIIIHQRT
     ILVNGLTSLE MRYKGKFDKQ KKEEIDENQP VTEVPNRTKS KQHPETRSNS TSQSTARLSH
     SNINDDQEDE QPEITEDQLE STDDQDTGSL YTALSAQQRD IFQNRNTNPS NKKWYENIKC
     MLFKNRKNKF YFADEELHRR IFQNQDQRFS LSCSQQFSEK DCLSKTESRN QLLMQYIK
//