ID   Q22CX0_TETTS            Unreviewed;       718 AA.
AC   Q22CX0;
DT   18-APR-2006, integrated into UniProtKB/TrEMBL.
DT   16-APR-2014, sequence version 3.
DT   05-JUN-2019, entry version 100.
DE   RecName: Full=Palmitoyltransferase {ECO:0000256|RuleBase:RU079119};
DE            EC=2.3.1.225 {ECO:0000256|RuleBase:RU079119};
GN   ORFNames=TTHERM_01014660 {ECO:0000313|EMBL:EAR83149.3};
OS   Tetrahymena thermophila (strain SB210).
OC   Eukaryota; Alveolata; Ciliophora; Intramacronucleata;
OC   Oligohymenophorea; Hymenostomatida; Tetrahymenina; Tetrahymenidae;
OC   Tetrahymena.
OX   NCBI_TaxID=312017 {ECO:0000313|EMBL:EAR83149.3, ECO:0000313|Proteomes:UP000009168};
RN   [1] {ECO:0000313|Proteomes:UP000009168}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=SB210 {ECO:0000313|Proteomes:UP000009168};
RX   PubMed=16933976; DOI=10.1371/journal.pbio.0040286;
RA   Eisen J.A., Coyne R.S., Wu M., Wu D., Thiagarajan M., Wortman J.R.,
RA   Badger J.H., Ren Q., Amedeo P., Jones K.M., Tallon L.J., Delcher A.L.,
RA   Salzberg S.L., Silva J.C., Haas B.J., Majoros W.H., Farzad M.,
RA   Carlton J.M., Smith R.K. Jr., Garg J., Pearlman R.E., Karrer K.M.,
RA   Sun L., Manning G., Elde N.C., Turkewitz A.P., Asai D.J., Wilkes D.E.,
RA   Wang Y., Cai H., Collins K., Stewart B.A., Lee S.R., Wilamowska K.,
RA   Weinberg Z., Ruzzo W.L., Wloga D., Gaertig J., Frankel J., Tsao C.-C.,
RA   Gorovsky M.A., Keeling P.J., Waller R.F., Patron N.J., Cherry J.M.,
RA   Stover N.A., Krieger C.J., del Toro C., Ryder H.F., Williamson S.C.,
RA   Barbeau R.A., Hamilton E.P., Orias E.;
RT   "Macronuclear genome sequence of the ciliate Tetrahymena thermophila,
RT   a model eukaryote.";
RL   PLoS Biol. 4:1620-1642(2006).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=hexadecanoyl-CoA + L-cysteinyl-[protein] = CoA + S-
CC         hexadecanoyl-L-cysteinyl-[protein]; Xref=Rhea:RHEA:36683,
CC         Rhea:RHEA-COMP:10131, Rhea:RHEA-COMP:11032, ChEBI:CHEBI:29950,
CC         ChEBI:CHEBI:57287, ChEBI:CHEBI:57379, ChEBI:CHEBI:74151;
CC         EC=2.3.1.225; Evidence={ECO:0000256|RuleBase:RU079119};
CC   -!- DOMAIN: The DHHC domain is required for palmitoyltransferase
CC       activity. {ECO:0000256|RuleBase:RU079119}.
CC   -!- SIMILARITY: Belongs to the DHHC palmitoyltransferase family.
CC       {ECO:0000256|RuleBase:RU079119, ECO:0000256|SAAS:SAAS00704637}.
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DR   EMBL; GG662521; EAR83149.3; -; Genomic_DNA.
DR   RefSeq; XP_001030812.3; XM_001030812.3.
DR   STRING; 5911.EAR83149; -.
DR   EnsemblProtists; EAR83149; EAR83149; TTHERM_01014660.
DR   GeneID; 7830086; -.
DR   KEGG; tet:TTHERM_01014660; -.
DR   InParanoid; Q22CX0; -.
DR   KO; K20032; -.
DR   OrthoDB; 445686at2759; -.
DR   Proteomes; UP000009168; Unassembled WGS sequence.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0000502; C:proteasome complex; IEA:UniProtKB-KW.
DR   GO; GO:0019706; F:protein-cysteine S-palmitoyltransferase activity; IEA:UniProtKB-EC.
DR   CDD; cd00204; ANK; 1.
DR   Gene3D; 1.25.40.20; -; 1.
DR   InterPro; IPR002110; Ankyrin_rpt.
DR   InterPro; IPR020683; Ankyrin_rpt-contain_dom.
DR   InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR   InterPro; IPR001594; Palmitoyltrfase_DHHC.
DR   Pfam; PF12796; Ank_2; 1.
DR   Pfam; PF01529; DHHC; 1.
DR   SMART; SM00248; ANK; 4.
DR   SUPFAM; SSF48403; SSF48403; 1.
DR   PROSITE; PS50297; ANK_REP_REGION; 1.
DR   PROSITE; PS50088; ANK_REPEAT; 1.
PE   3: Inferred from homology;
KW   Acyltransferase {ECO:0000256|RuleBase:RU079119,
KW   ECO:0000256|SAAS:SAAS00704618};
KW   ANK repeat {ECO:0000256|PROSITE-ProRule:PRU00023};
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000009168};
KW   Membrane {ECO:0000256|RuleBase:RU079119,
KW   ECO:0000256|SAAS:SAAS00704603};
KW   Proteasome {ECO:0000313|EMBL:EAR83149.3};
KW   Reference proteome {ECO:0000313|Proteomes:UP000009168};
KW   Transferase {ECO:0000256|RuleBase:RU079119,
KW   ECO:0000256|SAAS:SAAS00704617};
KW   Transmembrane {ECO:0000256|RuleBase:RU079119,
KW   ECO:0000256|SAAS:SAAS00704602};
KW   Transmembrane helix {ECO:0000256|RuleBase:RU079119,
KW   ECO:0000256|SAAS:SAAS00704622}.
FT   TRANSMEM    326    343       Helical. {ECO:0000256|RuleBase:RU079119}.
FT   TRANSMEM    349    371       Helical. {ECO:0000256|RuleBase:RU079119}.
FT   TRANSMEM    461    484       Helical. {ECO:0000256|RuleBase:RU079119}.
FT   TRANSMEM    511    536       Helical. {ECO:0000256|RuleBase:RU079119}.
FT   DOMAIN      108    261       ANK_REP_REGION. {ECO:0000259|PROSITE:
FT                                PS50297}.
FT   REPEAT      219    251       ANK. {ECO:0000256|PROSITE-ProRule:
FT                                PRU00023}.
FT   REGION      559    626       Disordered. {ECO:0000256|MobiDB-lite:
FT                                Q22CX0}.
FT   COILED      264    284       {ECO:0000256|SAM:Coils}.
FT   COMPBIAS    585    601       Polar. {ECO:0000256|MobiDB-lite:Q22CX0}.
FT   COMPBIAS    608    623       Acidic. {ECO:0000256|MobiDB-lite:Q22CX0}.
SQ   SEQUENCE   718 AA;  84166 MW;  47AA0EBB3E536A85 CRC64;
     MIPEKNIKNS VECFSGMQLP KNYSEAIKFL KSLSNQQNVK LDYIVEILKV YKGINLNKFP
     KFNLLVQAVK DNNEFAFNLF LDYLQQADIP QEDKIEYINS NKALNCEEGY NALQYAVYYE
     FQDMALKLIE KGARYDTHIN EIGDKIIHSA ARGGSLKVIM KLQQLGVDIF EKTQSKGLNL
     STFEIACFEG NLHIMKYLLK MDEFENQKRI DINEQHPVSK ETPLHLGIRS KDYSVVKFLL
     IQGANKQLKN NENQTPLQFA IWRKEKIQKK LKEKRETVDQ YQIMEWESKI NHLDSLISLL
     GDIKFFNRLK LQTRVGPTKG MNKYSYILRI INILGFIGFI FILPYTDLFI GFIVFFYSIY
     LCSFYCLFCS YKSDPGYIKQ LGYESYQLDL NNNQPASQKD TFVNNFWLLL CKKEFEELCL
     ECCIIKPVRS KHCDFCNRCV AVMDHHCPFI KNCVGAKNHR YFFFMLVTQA LSQISILIAC
     IFALKELQQD DIEDEHSHQF IDSCPQLFNP IIAYISISIL IIQFIITCFP LFFIIIHQRT
     ILVNGLTSLE MRYKGKFDKQ KKEEIDENQP VTEVPNRTKS KQHPETRSNS TSQSTARLSH
     SNINDDQEDE QPEITEDQLE STDDQDTGSL YTALSAQQRD IFQNRNTNPS NKKWYENIKC
     MLFKNRKNKF YFADEELHRR IFQNQDQRFS LSCSQQFSEK DCLSKTESRN QLLMQYIK
//