ID Q20QC9_9INFA Unreviewed; 97 AA. AC Q20QC9; DT 18-APR-2006, integrated into UniProtKB/TrEMBL. DT 18-APR-2006, sequence version 1. DT 25-APR-2018, entry version 53. DE RecName: Full=Matrix protein 2 {ECO:0000256|HAMAP-Rule:MF_04069, ECO:0000256|RuleBase:RU361247, ECO:0000256|SAAS:SAAS00395487}; DE AltName: Full=Proton channel protein M2 {ECO:0000256|HAMAP-Rule:MF_04069}; GN Name=M2 {ECO:0000313|EMBL:ABB88140.1}; GN Synonyms=M {ECO:0000256|HAMAP-Rule:MF_04069}; OS Influenza A virus (A/wedge-tailed shearwater/Western OS Australia/2576/1979(H15N9)). OC Viruses; ssRNA viruses; ssRNA negative-strand viruses; OC Orthomyxoviridae; Alphainfluenzavirus. OX NCBI_TaxID=352560 {ECO:0000313|EMBL:ABB88140.1, ECO:0000313|Proteomes:UP000103171}; RN [1] {ECO:0000313|EMBL:ABB88140.1, ECO:0000313|Proteomes:UP000103171} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=A/wedge-tailed shearwater/Western Australia/2576/1979 RC {ECO:0000313|EMBL:ABB88140.1}; RX PubMed=16439620; DOI=10.1126/science.1121586; RA Obenauer J.C., Denson J., Mehta P.K., Su X., Mukatira S., RA Finkelstein D.B., Xu X., Wang J., Ma J., Fan Y., Rakestraw K.M., RA Webster R.G., Hoffmann E., Krauss S., Zheng J., Zhang Z., Naeve C.W.; RT "Large-scale sequence analysis of avian influenza isolates."; RL Science 311:1576-1580(2006). CC -!- ENZYME REGULATION: The M2 protein from most influenza A strains is CC inhibited by amantadine and rimantadine, resulting in viral CC uncoating incapacity. Emergence of amantadine-resistant variants CC is usually rapid. {ECO:0000256|RuleBase:RU361247}. CC -!- SUBUNIT: Homotetramer; composed of two disulfide-linked dimers CC held together by non-covalent interactions. May interact with CC matrix protein 1. {ECO:0000256|HAMAP-Rule:MF_04069, CC ECO:0000256|RuleBase:RU361247, ECO:0000256|SAAS:SAAS00108524}. CC -!- SUBCELLULAR LOCATION: Host apical cell membrane CC {ECO:0000256|SAAS:SAAS00581620}; Single-pass type III membrane CC protein {ECO:0000256|SAAS:SAAS00581620}. CC -!- DOMAIN: Cytoplasmic tail plays an important role in virion CC assembly and morphogenesis. {ECO:0000256|HAMAP-Rule:MF_04069, CC ECO:0000256|RuleBase:RU361247}. CC -!- MISCELLANEOUS: When the channel is activated, one or more CC imidazole moities of His-37 probably become bi-protonated. CC {ECO:0000256|HAMAP-Rule:MF_04069}. CC -!- SIMILARITY: Belongs to the influenza viruses matrix protein M2 CC family. {ECO:0000256|HAMAP-Rule:MF_04069, CC ECO:0000256|RuleBase:RU361247, ECO:0000256|SAAS:SAAS00581646}. CC -!- CAUTION: Lacks conserved residue(s) required for the propagation CC of feature annotation. {ECO:0000256|HAMAP-Rule:MF_04069}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; CY005406; ABB88140.1; -; Other_RNA. DR SMR; Q20QC9; -. DR Proteomes; UP000103171; Genome. DR GO; GO:0020002; C:host cell plasma membrane; IEA:UniProtKB-SubCell. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-UniRule. DR GO; GO:0044385; C:integral to membrane of host cell; IEA:UniProtKB-UniRule. DR GO; GO:0055036; C:virion membrane; IEA:UniProtKB-UniRule. DR GO; GO:0005216; F:ion channel activity; IEA:UniProtKB-UniRule. DR GO; GO:0015078; F:proton transmembrane transporter activity; IEA:UniProtKB-UniRule. DR GO; GO:0039707; P:pore formation by virus in membrane of host cell; IEA:UniProtKB-UniRule. DR GO; GO:0051259; P:protein oligomerization; IEA:UniProtKB-UniRule. DR GO; GO:0039521; P:suppression by virus of host autophagy; IEA:UniProtKB-UniRule. DR HAMAP; MF_04069; INFV_M2; 1. DR InterPro; IPR002089; Flu_M2. DR Pfam; PF00599; Flu_M2; 1. DR ProDom; PD001031; Flu_M2; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000103171}; KW Disulfide bond {ECO:0000256|HAMAP-Rule:MF_04069, KW ECO:0000256|SAAS:SAAS00108279}; KW Host cell membrane {ECO:0000256|HAMAP-Rule:MF_04069, KW ECO:0000256|RuleBase:RU361247, ECO:0000256|SAAS:SAAS00108156}; KW Host membrane {ECO:0000256|HAMAP-Rule:MF_04069, KW ECO:0000256|RuleBase:RU361247, ECO:0000256|SAAS:SAAS00108238}; KW Host-virus interaction {ECO:0000256|HAMAP-Rule:MF_04069, KW ECO:0000256|SAAS:SAAS00472422}; KW Hydrogen ion transport {ECO:0000256|HAMAP-Rule:MF_04069, KW ECO:0000256|RuleBase:RU361247, ECO:0000256|SAAS:SAAS00108569}; KW Inhibition of host autophagy by virus {ECO:0000256|HAMAP- KW Rule:MF_04069, ECO:0000256|SAAS:SAAS00108142}; KW Ion channel {ECO:0000256|HAMAP-Rule:MF_04069, KW ECO:0000256|RuleBase:RU361247, ECO:0000256|SAAS:SAAS00108550}; KW Ion transport {ECO:0000256|HAMAP-Rule:MF_04069, KW ECO:0000256|RuleBase:RU361247, ECO:0000256|SAAS:SAAS00108149}; KW Lipoprotein {ECO:0000256|HAMAP-Rule:MF_04069}; KW Membrane {ECO:0000256|HAMAP-Rule:MF_04069, KW ECO:0000256|RuleBase:RU361247, ECO:0000256|SAAS:SAAS00108449, KW ECO:0000256|SAM:Phobius}; KW Palmitate {ECO:0000256|HAMAP-Rule:MF_04069}; KW Phosphoprotein {ECO:0000256|HAMAP-Rule:MF_04069}; KW Signal-anchor {ECO:0000256|HAMAP-Rule:MF_04069, KW ECO:0000256|RuleBase:RU361247}; KW Transmembrane {ECO:0000256|HAMAP-Rule:MF_04069, KW ECO:0000256|RuleBase:RU361247, ECO:0000256|SAAS:SAAS00108343, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|HAMAP-Rule:MF_04069, KW ECO:0000256|RuleBase:RU361247, ECO:0000256|SAAS:SAAS00108211, KW ECO:0000256|SAM:Phobius}; KW Transport {ECO:0000256|HAMAP-Rule:MF_04069, KW ECO:0000256|RuleBase:RU361247, ECO:0000256|SAAS:SAAS00108321}; KW Viral ion channel {ECO:0000256|HAMAP-Rule:MF_04069, KW ECO:0000256|SAAS:SAAS00108471}; KW Virion {ECO:0000256|HAMAP-Rule:MF_04069, KW ECO:0000256|RuleBase:RU361247, ECO:0000256|SAAS:SAAS00108457}. FT TOPO_DOM 1 22 Virion surface. {ECO:0000256|HAMAP-Rule: FT MF_04069}. FT TRANSMEM 26 48 Helical. {ECO:0000256|SAM:Phobius}. FT TOPO_DOM 44 97 Intravirion. {ECO:0000256|HAMAP-Rule: FT MF_04069}. FT SITE 37 37 Essential for channel activity, possibly FT by being protonated during channel FT activation, and by forming the channel FT gate and the selective filter. FT {ECO:0000256|HAMAP-Rule:MF_04069}. FT SITE 41 41 Seems to be involved in pH gating. FT {ECO:0000256|HAMAP-Rule:MF_04069}. FT MOD_RES 64 64 Phosphoserine; by host. FT {ECO:0000256|HAMAP-Rule:MF_04069}. FT MOD_RES 82 82 Phosphoserine; by host. FT {ECO:0000256|HAMAP-Rule:MF_04069}. FT LIPID 50 50 S-palmitoyl cysteine; by host. FT {ECO:0000256|HAMAP-Rule:MF_04069}. FT DISULFID 17 17 Interchain (with Cys-17). FT {ECO:0000256|HAMAP-Rule:MF_04069}. FT DISULFID 19 19 Interchain (with Cys-19). FT {ECO:0000256|HAMAP-Rule:MF_04069}. SQ SEQUENCE 97 AA; 11158 MW; FF12EFFCB4370398 CRC64; MSLLTEVETP TRNGWECKCS DSSDPLVIAA SIIGILHLIL WILDRLFFKC IYRRLKYGLK RGPSTEGVPE SMREEYRQEQ QSAVDVDDGH FVNIELE //