ID Q20QC9_9INFA Unreviewed; 97 AA. AC Q20QC9; DT 18-APR-2006, integrated into UniProtKB/TrEMBL. DT 18-APR-2006, sequence version 1. DT 01-MAY-2013, entry version 25. DE SubName: Full=Matrix protein 2; GN Name=M2; OS Influenza A virus (A/wedge-tailed shearwater/Western OS Australia/2576/1979(H15N9)). OC Viruses; ssRNA negative-strand viruses; Orthomyxoviridae; OC Influenzavirus A. OX NCBI_TaxID=352560; RN [1] RP NUCLEOTIDE SEQUENCE. RC STRAIN=A/wedge-tailed shearwater/Western Australia/2576/1979; RX PubMed=16439620; DOI=10.1126/science.1121586; RA Obenauer J.C., Denson J., Mehta P.K., Su X., Mukatira S., RA Finkelstein D.B., Xu X., Wang J., Ma J., Fan Y., Rakestraw K.M., RA Webster R.G., Hoffmann E., Krauss S., Zheng J., Zhang Z., Naeve C.W.; RT "Large-scale sequence analysis of avian influenza isolates."; RL Science 311:1576-1580(2006). CC -!- FUNCTION: Forms a proton-selective ion channel that is necessary CC for the efficient release of the viral genome during virus entry. CC After attaching to the cell surface, the virion enters the cell by CC endocytosis. Acidification of the endosome triggers M2 ion channel CC activity. The influx of protons into virion interior is believed CC to disrupt interactions between the viral ribonucleoprotein (RNP), CC matrix protein 1 (M1), and lipid bilayers, thereby freeing the CC viral genome from interaction with viral proteins and enabling RNA CC segments to migrate to the host cell nucleus, where influenza CC virus RNA transcription and replication occur. Also plays a role CC in viral proteins secretory pathway. Elevates the intravesicular CC pH of normally acidic compartments, such as trans-Golgi network, CC preventing newly formed hemagglutinin from premature switching to CC the fusion-active conformation (By similarity). CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; CY005406; ABB88140.1; -; Other_RNA. DR GO; GO:0020002; C:host cell plasma membrane; IEA:UniProtKB-KW. DR GO; GO:0016021; C:integral to membrane; IEA:UniProtKB-KW. DR GO; GO:0055036; C:virion membrane; IEA:InterPro. DR GO; GO:0015078; F:hydrogen ion transmembrane transporter activity; IEA:InterPro. DR InterPro; IPR002089; Flu_M2. DR Pfam; PF00599; Flu_M2; 1. DR ProDom; PD001031; Flu_M2; 1. PE 3: Inferred from homology; KW Disulfide bond; Host cell membrane; Host membrane; KW Hydrogen ion transport; Ion channel; Ion transport; Membrane; KW Phosphoprotein; Transmembrane; Transmembrane helix; Transport; Virion. SQ SEQUENCE 97 AA; 11158 MW; FF12EFFCB4370398 CRC64; MSLLTEVETP TRNGWECKCS DSSDPLVIAA SIIGILHLIL WILDRLFFKC IYRRLKYGLK RGPSTEGVPE SMREEYRQEQ QSAVDVDDGH FVNIELE //