ID Q1YDX4_MOBAS Unreviewed; 367 AA. AC Q1YDX4; DT 02-MAY-2006, integrated into UniProtKB/TrEMBL. DT 02-MAY-2006, sequence version 1. DT 30-NOV-2010, entry version 23. DE RecName: Full=Probable O-sialoglycoprotein endopeptidase; DE Short=Glycoprotease; DE EC=3.4.24.57; GN Name=gcp; ORFNames=SI859A1_03651; OS Manganese-oxidizing bacterium (strain SI85-9A1). OC Bacteria; Proteobacteria; Alphaproteobacteria; Rhizobiales; OC Aurantimonadaceae; Aurantimonas. OX NCBI_TaxID=287752; RN [1] RP NUCLEOTIDE SEQUENCE. RC STRAIN=SI85-9A1; RX PubMed=18344346; DOI=10.1128/AEM.01656-07; RA Dick G.J., Podell S., Johnson H.A., Rivera-Espinoza Y., RA Bernier-Latmani R., McCarthy J.K., Torpey J.W., Clement B.G., RA Gaasterland T., Tebo B.M.; RT "Genomic insights into Mn(II) oxidation by the marine RT alphaproteobacterium Aurantimonas sp. strain SI85-9A1."; RL Appl. Environ. Microbiol. 74:2646-2658(2008). CC -!- CATALYTIC ACTIVITY: Hydrolysis of O-sialoglycoproteins; cleaves CC 31-Arg-|-Asp-32 bond in glycophorin A. Does not cleave CC unglycosylated proteins, desialylated glycoproteins or CC glycoproteins that are only N-glycosylated. CC -!- COFACTOR: Zinc (By similarity). CC -!- SIMILARITY: Belongs to the peptidase M22 family. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AAPJ01000010; EAS48484.1; -; Genomic_DNA. DR ProteinModelPortal; Q1YDX4; -. DR SMR; Q1YDX4; 10-353. DR MEROPS; M22.001; -. DR NMPDR; fig|314269.3.peg.459; -. DR GO; GO:0004222; F:metalloendopeptidase activity; IEA:HAMAP. DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro. DR GO; GO:0006508; P:proteolysis; IEA:InterPro. DR HAMAP; MF_01445; Glycoptase_bact; 1; -. DR InterPro; IPR022450; Pept_M22_O-sialoglycopept. DR InterPro; IPR000905; Peptidase_M22. DR InterPro; IPR017861; Peptidase_M22_subgr. DR PANTHER; PTHR11735; Pept_M22_Osialgl; 1. DR Pfam; PF00814; Peptidase_M22; 1. DR PRINTS; PR00789; OSIALOPTASE. DR TIGRFAMs; TIGR03723; Bact_gcp; 1. DR TIGRFAMs; TIGR00329; gcp; 1. PE 3: Inferred from homology; KW Hydrolase; Metal-binding; Metalloprotease; Protease; Zinc. FT METAL 123 123 Zinc (By similarity). FT METAL 127 127 Zinc (By similarity). SQ SEQUENCE 367 AA; 37990 MW; 110BFAFE5862144F CRC64; MTPANPPRPL ILGIETSCDE TAASVVGRDD AGAPVIHSNV VLSQVEEHAA FGGVVPEIAA RAHVEALDGI VKAAMDEAGI GFDELSAVAA TTGPGLVGGL IVGAMTGKAI AAARRLPFLA INHLEGHALT PRLTDRLAYP YLLLLVSGGH SQIVLVRGLG AYERWGTTID DALGEAFDKT AKLLGLPNPG GPHVERRAAA GDPKRFALPR PMKGNPRLDF SFSGLKTALR MAAQAAAPLS PTDVDDLCAG FQAAAADSLA DRVGRALTQF RDRFPDLADP VLAVAGGVAA NRAIRTALEA QTARTGVRLV APPLALCTDN AAMIAYAGLE RFEAGMVDGL DAPVRSRWPL DGDSAPMIGF GRRGAKA //