ID Q1WDL8_9INFA Unreviewed; 567 AA. AC Q1WDL8; DT 02-MAY-2006, integrated into UniProtKB/TrEMBL. DT 02-MAY-2006, sequence version 1. DT 11-SEP-2007, entry version 11. DE Hemagglutinin. GN Name=HA; OS Influenza A virus (A/Guangxi/1/2005(H5N1)). OC Viruses; ssRNA negative-strand viruses; Orthomyxoviridae; OC Influenzavirus A. OX NCBI_TaxID=370812; RN [1] RP NUCLEOTIDE SEQUENCE. RC STRAIN=A/Guangxi/1/2005; RA Shu Y., Yu H., Li D.; RT "Lethal Avian Influenza (H5N1) Infection in a Pregnant Woman, Anhui RT Province, China."; RL Submitted (JAN-2006) to the EMBL/GenBank/DDBJ databases. CC -!- FUNCTION: Binds to sialic acid-containing receptors on the cell CC surface, bringing about the attachment of the virus particle to CC the cell. Plays a major role in the determination of host range CC restriction and virulence. Class I viral fusion protein. CC Responsible for penetration of the virus into the cell cytoplasm CC by mediating the fusion of the membrane of the endocytosed virus CC particle with the endosomal membrane. Low pH in endosomes induce CC an irreversible conformational change in HA2, releasing the fusion CC hydrophobic peptide. Several trimers are required to form a CC competent fusion pore (By similarity). CC -!- SUBUNIT: Homotrimer of disulfide-linked HA1-HA2 (By similarity). CC -!- SUBCELLULAR LOCATION: Apical cell membrane; Single-pass type I CC membrane protein. Note=Targeted to the apical plasma membrane in CC epithelial polarized cells through a signal present in the CC transmembrane domain. Associated with glycosphingolipid- and CC cholesterol-enriched detergent-resistant lipid rafts (By CC similarity). CC -!- SIMILARITY: Belongs to the influenza viruses hemagglutinin family. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; DQ371930; ABD28182.1; -; Genomic_RNA. DR SMR; Q1WDL8; 17-337. DR GO; GO:0019031; C:viral envelope; IEA:InterPro. DR GO; GO:0046789; F:host cell surface receptor binding; IEA:InterPro. DR GO; GO:0019064; P:viral envelope fusion with host membrane; IEA:InterPro. DR InterPro; IPR013827; Haemagglutn_HA1_b-ribbon. DR InterPro; IPR000149; Haemagglutn_influenz_HA1. DR InterPro; IPR001364; Haemagglutn_influenz_HA1/HA2. DR InterPro; IPR013829; Haemagglutn_stalk. DR Gene3D; G3DSA:2.10.77.10; Haemagglutn_HA1_b-ribbon; 1. DR Gene3D; G3DSA:3.90.20.10; Haemagglutn_stalk; 1. DR Pfam; PF00509; Hemagglutinin; 1. DR PRINTS; PR00330; HEMAGGLUTN1. DR PRINTS; PR00329; HEMAGGLUTN12. DR ProDom; PD000225; Hemagglutn; 1. PE 3: Inferred from homology; KW Envelope protein; Fusion protein; Hemagglutinin; Membrane; KW Transmembrane; Virion. SQ SEQUENCE 567 AA; 64058 MW; DF9D13166F723572 CRC64; MEKIVLLLAI VSLVKSDQIC IGYHANNSTE QVDTIMEKNV TVTHAQDILE KTHNGKLCDL DGVKPLILRD CSVAGWLLGN PMCDEFINVP EWSYIVEKAN PANDLCYPGN FNDYEELKHL LSRINHFEKI QIIPKSSWSD HEASSGGSSA CPYQGTPSFF RNVVWLIKKN NTYPTIKRSY NNTNQEDLLI LWGIHHSNDA AEQTKLYQNP TTYISVGTST LNQRLVPKIA TRSKVNGQSG RMDFFWTILK PNDAINFESN GNFIAPEYAY KIVKKGDSAI MKSEVEYGNC NTKCQTPIGA INSSMPFHNI HPLTIGECPK YVKSNKLVLA TGLRNSPLRE RRRKRGLFGA IAGFIEGGWQ GMVDGWYGYH HSNEQGSGYA ADKESTQKAI DGVTNKVNSI IDKMNTQFEA VGREFNNLER RIENLNKKME DGFLDVWTYN AELLVLMENE RTLDFHDSNV KNLYDKVRLQ LRDNAKELGN GCFEFYHKCD NECMESVRNG TYDYPQYSEE ARLKREEISG VKLESIGTYQ ILSIYSTVAS SLALAIMVAG LSLWMCSNGS LQCRICI //