ID TPC11_DANRE Reviewed; 1132 AA. AC Q1RLX4; Q6DRL6; Q6PGX1; DT 02-SEP-2008, integrated into UniProtKB/Swiss-Prot. DT 16-MAY-2006, sequence version 1. DT 02-OCT-2024, entry version 105. DE RecName: Full=Trafficking protein particle complex subunit 11; DE AltName: Full=Protein foie gras; GN Name=trappc11; Synonyms=fgr, foigr; ORFNames=zgc:136723, zgc:63684; OS Danio rerio (Zebrafish) (Brachydanio rerio). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; OC Danionidae; Danioninae; Danio. OX NCBI_TaxID=7955; RN [1] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). RC TISSUE=Embryo; RX PubMed=15256591; DOI=10.1073/pnas.0403929101; RA Amsterdam A., Nissen R.M., Sun Z., Swindell E.C., Farrington S., RA Hopkins N.; RT "Identification of 315 genes essential for early zebrafish development."; RL Proc. Natl. Acad. Sci. U.S.A. 101:12792-12797(2004). RN [2] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2). RC STRAIN=SJD; RG NIH - Zebrafish Gene Collection (ZGC) project; RL Submitted (APR-2006) to the EMBL/GenBank/DDBJ databases. RN [3] RP DISRUPTION PHENOTYPE. RX PubMed=16000385; DOI=10.1242/dev.01918; RA Sadler K.C., Amsterdam A., Soroka C., Boyer J., Hopkins N.; RT "A genetic screen in zebrafish identifies the mutants vps18, nf2 and foie RT gras as models of liver disease."; RL Development 132:3561-3572(2005). CC -!- FUNCTION: Involved in endoplasmic reticulum to Golgi apparatus CC trafficking at a very early stage. {ECO:0000250}. CC -!- SUBUNIT: Component of the multisubunit TRAPP (transport protein CC particle) complex. {ECO:0000250}. CC -!- SUBCELLULAR LOCATION: Golgi apparatus {ECO:0000250|UniProtKB:Q7Z392}. CC Golgi apparatus, cis-Golgi network {ECO:0000250}. CC -!- ALTERNATIVE PRODUCTS: CC Event=Alternative splicing; Named isoforms=2; CC Name=1; CC IsoId=Q1RLX4-1; Sequence=Displayed; CC Name=2; CC IsoId=Q1RLX4-2; Sequence=VSP_035103; CC -!- DISRUPTION PHENOTYPE: Pronounced hepatomegaly accompanied by lipid CC accumulation in the liver. {ECO:0000269|PubMed:16000385}. CC -!- SIMILARITY: Belongs to the TRAPPC11 family. {ECO:0000305}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AY648743; AAT68061.1; -; mRNA. DR EMBL; BC056800; AAH56800.1; -; mRNA. DR EMBL; BC115242; AAI15243.1; -; mRNA. DR RefSeq; NP_955920.2; NM_199626.2. DR RefSeq; XP_005157179.1; XM_005157122.3. [Q1RLX4-1] DR AlphaFoldDB; Q1RLX4; -. DR SMR; Q1RLX4; -. DR STRING; 7955.ENSDARP00000054808; -. DR PaxDb; 7955-ENSDARP00000054808; -. DR Ensembl; ENSDART00000054809; ENSDARP00000054808; ENSDARG00000004726. [Q1RLX4-1] DR GeneID; 323003; -. DR KEGG; dre:323003; -. DR AGR; ZFIN:ZDB-GENE-030131-1723; -. DR CTD; 60684; -. DR ZFIN; ZDB-GENE-030131-1723; trappc11. DR eggNOG; KOG4386; Eukaryota. DR HOGENOM; CLU_003649_0_0_1; -. DR InParanoid; Q1RLX4; -. DR OMA; CVEYYRD; -. DR OrthoDB; 6533at2759; -. DR PhylomeDB; Q1RLX4; -. DR TreeFam; TF314022; -. DR PRO; PR:Q1RLX4; -. DR Proteomes; UP000000437; Chromosome 14. DR Bgee; ENSDARG00000004726; Expressed in intestine and 28 other cell types or tissues. DR GO; GO:0005794; C:Golgi apparatus; IEA:UniProtKB-SubCell. DR GO; GO:0007030; P:Golgi organization; IMP:ZFIN. DR GO; GO:0055088; P:lipid homeostasis; IGI:ZFIN. DR GO; GO:0001889; P:liver development; IMP:ZFIN. DR GO; GO:0006487; P:protein N-linked glycosylation; IMP:ZFIN. DR GO; GO:0009306; P:protein secretion; IMP:ZFIN. DR GO; GO:1905897; P:regulation of response to endoplasmic reticulum stress; IGI:ZFIN. DR GO; GO:0060041; P:retina development in camera-type eye; IMP:ZFIN. DR GO; GO:0016192; P:vesicle-mediated transport; IEA:UniProtKB-KW. DR InterPro; IPR021773; TPC11. DR InterPro; IPR025876; TRAPPC11_C. DR PANTHER; PTHR14374; FOIE GRAS; 1. DR PANTHER; PTHR14374:SF0; TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT 11; 1. DR Pfam; PF11817; Foie-gras_1; 1. DR Pfam; PF12742; Gryzun-like; 1. PE 2: Evidence at transcript level; KW Alternative splicing; ER-Golgi transport; Golgi apparatus; KW Reference proteome; Transport. FT CHAIN 1..1132 FT /note="Trafficking protein particle complex subunit 11" FT /id="PRO_0000348075" FT VAR_SEQ 339..938 FT /note="Missing (in isoform 2)" FT /evidence="ECO:0000303|Ref.2" FT /id="VSP_035103" FT CONFLICT 5 FT /note="R -> Q (in Ref. 1; AAT68061 and 2; AAH56800)" FT /evidence="ECO:0000305" FT CONFLICT 1118 FT /note="V -> I (in Ref. 2; AAH56800)" FT /evidence="ECO:0000305" SQ SEQUENCE 1132 AA; 128647 MW; EBA227724FE58452 CRC64; MSPARWDLPP ELCCRPMAFV ALTGLDVVYN AIHRAIWDAF CANRRADRVP ISFKVLPGDH EYPKCRTKRT SYEWYIPKGI LKTGWMNKHL NLVPALVVLF YELDWDDPQW KEKQSECATK VEIVRTSLQG RNTKVAVVLI QKKTPLPPGE DLVASERASA LCGACDLSGK SLFVLPHTDH LVGYIIRLEN AFYEHAQTYY YNEIRRVKSH KEFLNKTTHQ LLFVRHQFKM GFFSELKQDT QNALKYYRTA YSLVHELRAH ETNVLEIKTM AGFINYKICR LCFQHNTPLD AIAQFRKHID LCKKKIGSAE LAFEHTAWMS KQFQSFGDLF DEAIKLGLTA IQTQNPGFYY QQAAYYAQER KQQAGQLCSH EPGVGYPAPD PLETTSGALD FYGQRPWRQG HQSIDPPDSE KEKQGILALQ VKERDVLHSE LIIALLSNAV AQFKKYKCPR MKSHLMVQMG EEYYHAKDYT KALKLLDYVM CDYRTERWWS LLTSIVCTAL KCSYLMGQVK DYITYSMELV GRASILSEEQ KSRIEKNLIK VLMNEVPEPE PDCDPVSVKA AQSLWSDRVS LAGNNEFTID VQDYVPFVQC KAKFLSPSFH IDEPVQLHVY VRADCPHPVR FSKLCVSLSN QEYNQYCLLE DAYKGKDILE PSSQENMCLV PGKTRKYCFN FVAKTEDVGK KIEITSVGLM LGRETGRYVY LNWRGGWGDA ASSHESLQAS RSFKRRTRLP EQHVDWDAVS VQSSTMIISR VPKISVQLTH EPPALTNEMF CMTVTIKSEE DTVGKDIKLT AGLKPGQDAN LTQSTQITLN GSEVCDDSHP ALLPDIPLGD LQPGQKIVKP LYIRCVSTGS RIFLFHVAYS VSATVEGKDI TCKCHKDETV TVETVVPFEV AMKFVSSKFE HLERVYVDIP FLLMMDILSA SPWPIELVES EVQLASSMTA IDQPQSQVEG VTLQTSECAS ECFLLKCPPV QNGTSTVASG HYIISWKRKS TFTETSVVRT VITLPHVMVE NIPLYVHAEV PSFGRVRESL PVRYHLENRT GLVQDVEISV EPSDAFMFSG LKQVRMRILP GAEQEMLYNF YPLMAGYQVL PQLNINLLRF PNISSQLLRR FLPSRIFVKP QGRNGDASIE AA //