ID FTHS_LAWIP Reviewed; 591 AA. AC Q1MPZ9; DT 10-JUL-2007, integrated into UniProtKB/Swiss-Prot. DT 30-MAY-2006, sequence version 1. DT 29-MAY-2013, entry version 43. DE RecName: Full=Formate--tetrahydrofolate ligase; DE EC=6.3.4.3; DE AltName: Full=Formyltetrahydrofolate synthetase; DE Short=FHS; DE Short=FTHFS; GN Name=fhs; OrderedLocusNames=LI0874; OS Lawsonia intracellularis (strain PHE/MN1-00). OC Bacteria; Proteobacteria; Deltaproteobacteria; Desulfovibrionales; OC Desulfovibrionaceae; Lawsonia. OX NCBI_TaxID=363253; RN [1] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=PHE/MN1-00; RA Kaur K., Zhang Q., Beckler D., Munir S., Li L., Kinsley K., Herron L., RA Peterson A., May B., Singh S., Gebhart C., Kapur V.; RT "The complete genome sequence of Lawsonia intracellularis: the RT causative agent of proliferative enteropathy."; RL Submitted (NOV-2005) to the EMBL/GenBank/DDBJ databases. CC -!- CATALYTIC ACTIVITY: ATP + formate + tetrahydrofolate = ADP + CC phosphate + 10-formyltetrahydrofolate. CC -!- PATHWAY: One-carbon metabolism; tetrahydrofolate interconversion. CC -!- SIMILARITY: Belongs to the formate--tetrahydrofolate ligase CC family. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AM180252; CAJ54928.1; -; Genomic_DNA. DR RefSeq; YP_595249.1; NC_008011.1. DR ProteinModelPortal; Q1MPZ9; -. DR STRING; 363253.LI0874; -. DR GeneID; 4059356; -. DR KEGG; lip:LI0874; -. DR PATRIC; 22305255; VBILawInt40445_0949. DR eggNOG; COG2759; -. DR HOGENOM; HOG000040280; -. DR KO; K01938; -. DR OMA; EIMAVLC; -. DR ProtClustDB; PRK13507; -. DR BioCyc; LINT363253:GH6E-906-MONOMER; -. DR UniPathway; UPA00193; -. DR GO; GO:0005524; F:ATP binding; IEA:HAMAP. DR GO; GO:0004329; F:formate-tetrahydrofolate ligase activity; IEA:HAMAP. DR GO; GO:0009396; P:folic acid-containing compound biosynthetic process; IEA:InterPro. DR GO; GO:0035999; P:tetrahydrofolate interconversion; IEA:UniProtKB-UniPathway. DR HAMAP; MF_01543; FTHFS; 1; -. DR InterPro; IPR000559; Formate_THF_ligase. DR InterPro; IPR020628; Formate_THF_ligase_CS. DR InterPro; IPR027417; P-loop_NTPase. DR Pfam; PF01268; FTHFS; 1. DR SUPFAM; SSF52540; SSF52540; 1. DR PROSITE; PS00721; FTHFS_1; 1. DR PROSITE; PS00722; FTHFS_2; FALSE_NEG. PE 3: Inferred from homology; KW ATP-binding; Complete proteome; Ligase; Nucleotide-binding; KW One-carbon metabolism. FT CHAIN 1 591 Formate--tetrahydrofolate ligase. FT /FTId=PRO_0000293044. FT NP_BIND 74 81 ATP (By similarity). SQ SEQUENCE 591 AA; 64251 MW; C08387A37F820458 CRC64; MSLSPLNYAD WEIAQAAEKH MKTVYDLGKD LGLDHKEIFP YGHYMGKVDY KSVLSRLEQS SDGKYIDVTA ITPTPLGEGK STTTIGLVQG LAKRGKRSSA AIRQPSGGPT MGVKGSAAGG GLSQCIPLTQ YSLGFTGDIN AVMNAHNLSM VALTSRMQHE RNYSDEKLYA LSNMKRLDID PTNIPMGWVM DFCCQSLRNI IIGIDGVSGK SDGYMMRSHF DIAVSSEVMA ILAIAKDLKD FRQRISKIIV AYDKQGKAIT TADLEVDGAM TAWMVEAINP NLIQSIEGQP IFVHAGPFAN IAIGQSSVIA DRLGLKLSEY HVTESGFGVD IGYEKFWNLK CHYSGLTPDA AVIVTTVRAL KSHGGAPIPI PGRPLPKEYT EENVGYVEVG SANLIHHINT VKKSGVPPVV CINAFTTDTP SEIAKIRQLC ELVGARVAVS KHWEYGGDGA LELADAVIDA CNEEKNFLPL YDWSLPLKER IEKIAFEVYG AEGVEFSEEA IYKLNKLQAD NNSSDLGVCM VKTHLSLSDD PKQKGVPDHW KLHVRDIMFF GGAGFVVPIA GSITLMPGTG SNPSFRRIDV DTDTGKVKGI F //