ID   TRPC_RHIL3              Reviewed;         270 AA.
AC   Q1MGE1;
DT   15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT   30-MAY-2006, sequence version 1.
DT   31-JAN-2018, entry version 65.
DE   RecName: Full=Indole-3-glycerol phosphate synthase {ECO:0000255|HAMAP-Rule:MF_00134};
DE            Short=IGPS {ECO:0000255|HAMAP-Rule:MF_00134};
DE            EC=4.1.1.48 {ECO:0000255|HAMAP-Rule:MF_00134};
GN   Name=trpC {ECO:0000255|HAMAP-Rule:MF_00134}; OrderedLocusNames=RL2494;
OS   Rhizobium leguminosarum bv. viciae (strain 3841).
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Rhizobiales;
OC   Rhizobiaceae; Rhizobium/Agrobacterium group; Rhizobium.
OX   NCBI_TaxID=216596;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=3841;
RX   PubMed=16640791; DOI=10.1186/gb-2006-7-4-r34;
RA   Young J.P.W., Crossman L.C., Johnston A.W.B., Thomson N.R.,
RA   Ghazoui Z.F., Hull K.H., Wexler M., Curson A.R.J., Todd J.D.,
RA   Poole P.S., Mauchline T.H., East A.K., Quail M.A., Churcher C.,
RA   Arrowsmith C., Cherevach I., Chillingworth T., Clarke K., Cronin A.,
RA   Davis P., Fraser A., Hance Z., Hauser H., Jagels K., Moule S.,
RA   Mungall K., Norbertczak H., Rabbinowitsch E., Sanders M., Simmonds M.,
RA   Whitehead S., Parkhill J.;
RT   "The genome of Rhizobium leguminosarum has recognizable core and
RT   accessory components.";
RL   Genome Biol. 7:R34.1-R34.20(2006).
CC   -!- CATALYTIC ACTIVITY: 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-
CC       phosphate = 1-C-(3-indolyl)-glycerol 3-phosphate + CO(2) + H(2)O.
CC       {ECO:0000255|HAMAP-Rule:MF_00134}.
CC   -!- PATHWAY: Amino-acid biosynthesis; L-tryptophan biosynthesis; L-
CC       tryptophan from chorismate: step 4/5. {ECO:0000255|HAMAP-
CC       Rule:MF_00134}.
CC   -!- SIMILARITY: Belongs to the TrpC family. {ECO:0000255|HAMAP-
CC       Rule:MF_00134}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AM236080; CAK07982.1; -; Genomic_DNA.
DR   RefSeq; WP_011652054.1; NC_008380.1.
DR   ProteinModelPortal; Q1MGE1; -.
DR   SMR; Q1MGE1; -.
DR   STRING; 216596.RL2494; -.
DR   EnsemblBacteria; CAK07982; CAK07982; RL2494.
DR   KEGG; rle:RL2494; -.
DR   eggNOG; ENOG4105DK0; Bacteria.
DR   eggNOG; COG0134; LUCA.
DR   HOGENOM; HOG000230463; -.
DR   KO; K01609; -.
DR   OMA; RKDFMVD; -.
DR   OrthoDB; POG091H02GI; -.
DR   UniPathway; UPA00035; UER00043.
DR   Proteomes; UP000006575; Chromosome.
DR   GO; GO:0004425; F:indole-3-glycerol-phosphate synthase activity; IEA:UniProtKB-EC.
DR   GO; GO:0000162; P:tryptophan biosynthetic process; IEA:UniProtKB-UniPathway.
DR   CDD; cd00331; IGPS; 1.
DR   Gene3D; 3.20.20.70; -; 1.
DR   HAMAP; MF_00134_B; IGPS_B; 1.
DR   InterPro; IPR013785; Aldolase_TIM.
DR   InterPro; IPR013798; Indole-3-glycerol_P_synth.
DR   InterPro; IPR001468; Indole-3-GlycerolPSynthase_CS.
DR   InterPro; IPR011060; RibuloseP-bd_barrel.
DR   Pfam; PF00218; IGPS; 1.
DR   SUPFAM; SSF51366; SSF51366; 1.
DR   PROSITE; PS00614; IGPS; 1.
PE   3: Inferred from homology;
KW   Amino-acid biosynthesis; Aromatic amino acid biosynthesis;
KW   Complete proteome; Decarboxylase; Lyase; Reference proteome;
KW   Tryptophan biosynthesis.
FT   CHAIN         1    270       Indole-3-glycerol phosphate synthase.
FT                                /FTId=PRO_1000018541.
SQ   SEQUENCE   270 AA;  29086 MW;  AB458A6985C28209 CRC64;
     MTDILKKIEL YKREEIAAAK ATVSLADLKA MQAGQSAPRG FHKALIAKRD AGRFGLIAEI
     KKASPSKGLI RPDFDPPSLA SAYEAGGAAC LSVLTDTPSF QGAPEFLTAA RSACTLPALR
     KDFMFETYQV HEARAWGADC ILLIMASLSD DEAERLQDEA FALGMDVLVE VHDAEEMERA
     LKLSSPLIGI NNRNLRTFEV SLTVSEALAP MVSADRLLVG ESGIFTHADC KRLQAVDINT
     FLVGESLMRK EDVAAATRAL LFGEAAIAAE
//